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学科主题: 药学
题名:
Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells
作者: Li, Ke-Ke; Yao, Chun-Mei; Yang, Xiu-Wei
关键词: Panax ginseng ; Araliaceae ; dammarane triterpenoids ; saponin ; cytotoxicity ; HL-60
刊名: PLANTA MEDICA
发表日期: 2012
DOI: 10.1055/s-0031-1280320
卷: 78, 期:2, 页:189-192
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: KOREAN RED GINSENG ; CA MEYER ; NOTOGINSENG ; GLYCOSIDES ; COMPOUND
英文摘要:

Four new triterpene saponins, ginsenosides Rh-14-Rh-17 (1-4), along with two known compounds, 20(S)-ginsenoside Rg(2) and dammar-(E)-20(22),24-diene-3 beta,6 alpha,12 beta-triol, were isolated from the stems and leaves of Panax ginseng. The structures of the new compounds were elucidated as 3 beta,6 alpha,12 beta,24 xi-tetrahydroxydammar-(E)-20(22),25-diene 6-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (1), 3 beta,12 beta,24 xi-trihydroxy-dammar-(E)-20 (22),25-diene 3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (2), 3 beta,6 alpha,12 beta-trihydroxy-dammar-(E)-20(22),24-diene 3-O-beta-D-glucopyranoside (3), and 3-oxo-6 alpha,12 beta,20(S)-trihydroxydammar-24-ene 6-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (4) by means of extensive spectroscopic and chemical methods, respectively. The isolated compounds were tested for in vitro cytotoxicity against HL-60 cells.

语种: 英语
所属项目编号: 96-901-01-12 ; 2011BAI031B01
项目资助者: National Key Technology R &amp ; D Program of China
WOS记录号: WOS:000299909300016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60245
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Ke-Ke,Yao, Chun-Mei,Yang, Xiu-Wei. Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells[J]. PLANTA MEDICA,2012,78(2):189-192.
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