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Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells
Li, Ke-Ke; Yao, Chun-Mei; Yang, Xiu-Wei
关键词Panax ginseng Araliaceae dammarane triterpenoids saponin cytotoxicity HL-60
刊名PLANTA MEDICA
2012
DOI10.1055/s-0031-1280320
78期:2页:189-192
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]KOREAN RED GINSENG ; CA MEYER ; NOTOGINSENG ; GLYCOSIDES ; COMPOUND
英文摘要

Four new triterpene saponins, ginsenosides Rh-14-Rh-17 (1-4), along with two known compounds, 20(S)-ginsenoside Rg(2) and dammar-(E)-20(22),24-diene-3 beta,6 alpha,12 beta-triol, were isolated from the stems and leaves of Panax ginseng. The structures of the new compounds were elucidated as 3 beta,6 alpha,12 beta,24 xi-tetrahydroxydammar-(E)-20(22),25-diene 6-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (1), 3 beta,12 beta,24 xi-trihydroxy-dammar-(E)-20 (22),25-diene 3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (2), 3 beta,6 alpha,12 beta-trihydroxy-dammar-(E)-20(22),24-diene 3-O-beta-D-glucopyranoside (3), and 3-oxo-6 alpha,12 beta,20(S)-trihydroxydammar-24-ene 6-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (4) by means of extensive spectroscopic and chemical methods, respectively. The isolated compounds were tested for in vitro cytotoxicity against HL-60 cells.

语种英语
WOS记录号WOS:000299909300016
项目编号96-901-01-12 ; 2011BAI031B01
资助机构National Key Technology R &amp ; D Program of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60245
专题北京大学药学院
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
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Li, Ke-Ke,Yao, Chun-Mei,Yang, Xiu-Wei. Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells[J]. PLANTA MEDICA,2012,78(2):189-192.
APA Li, Ke-Ke,Yao, Chun-Mei,&Yang, Xiu-Wei.(2012).Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells.PLANTA MEDICA,78(2),189-192.
MLA Li, Ke-Ke,et al."Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells".PLANTA MEDICA 78.2(2012):189-192.
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