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Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study
Sui, Xizhao; Zhao, Hui; Wang, Jun; Yang, Feng; Yang, Fan; Li, Yun
关键词lung cancer VATS lobectomy elderly
刊名ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
2015
DOI10.5761/atcs.oa.15-00126
21期:6页:529-535
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Surgery
研究领域[WOS]Cardiovascular System & Cardiology ; Surgery
关键词[WOS]LONG-TERM SURVIVAL ; PULMONARY RESECTION ; PREOPERATIVE ASSESSMENT ; THORACIC-SURGERY ; CO-MORBIDITY ; TASK-FORCE ; POPULATION ; DATABASE ; COMPLICATIONS ; MANAGEMENT
英文摘要

Purpose: To analyze the short-term and long-term outcome of video-assisted thoracic surgery (VATS) lobectomy for elderly patients with non-small cell lung cancer.

Methods: 105 patients aged >= 75 years with resected non-small cell lung cancer were matched with 105 younger patients by propensity score. Survival rates were calculated by the Kaplan-Meier method. The cumulative incidence functions of conditional survival rate according to the age of the patients were calculated by competing risk analysis.

Results: patients >= 75 years was associated with higher postoperative complication rate (p < 0.001), but similar perioperative death rate (p = 0.006). Patients >= 75 years were less likely to receive adjuvant chemotherapy (p < 0.001). The 5-year overall survival rates were 54.6% for patients >= 75 years and 74.1% for patients <75 years (p = 0.001). No difference was seen in disease-free survival rate (59.5% vs. 71.9% respectively = 0.117). The cumulative incidence functions of 5-year cancer-specific death were similar between the two groups (28.7% vs. 24.6% respectively, p = 0.106). The cumulative incidence functions of 5-year non-cancer-specific death was significantly higher in the elderly group (18.7% vs. 1.0%, p < 0.001).

Conclusions: VATS lobectomy for non-small-cell lung cancer in patients >= 75 years were feasible with increased morbidity but similar mortality. The resected elderly patients were more frequently associated with non-cancer-specific death.

语种英语
WOS记录号WOS:000366805200005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60247
专题北京大学第二临床医学院_胸外科
北京大学基础医学院
作者单位Peking Univ, Peoples Hosp, Ctr Mini Invas Thorac Surg, Dept Thorac Surg, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Sui, Xizhao,Zhao, Hui,Wang, Jun,et al. Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study[J]. ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY,2015,21(6):529-535.
APA Sui, Xizhao,Zhao, Hui,Wang, Jun,Yang, Feng,Yang, Fan,&Li, Yun.(2015).Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study.ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY,21(6),529-535.
MLA Sui, Xizhao,et al."Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study".ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY 21.6(2015):529-535.
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