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学科主题: 临床医学
题名:
Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study
作者: Sui, Xizhao; Zhao, Hui; Wang, Jun; Yang, Feng; Yang, Fan; Li, Yun
关键词: lung cancer ; VATS ; lobectomy ; elderly
刊名: ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
发表日期: 2015
DOI: 10.5761/atcs.oa.15-00126
卷: 21, 期:6, 页:529-535
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Surgery
研究领域[WOS]: Cardiovascular System & Cardiology ; Surgery
关键词[WOS]: LONG-TERM SURVIVAL ; PULMONARY RESECTION ; PREOPERATIVE ASSESSMENT ; THORACIC-SURGERY ; CO-MORBIDITY ; TASK-FORCE ; POPULATION ; DATABASE ; COMPLICATIONS ; MANAGEMENT
英文摘要:

Purpose: To analyze the short-term and long-term outcome of video-assisted thoracic surgery (VATS) lobectomy for elderly patients with non-small cell lung cancer.

Methods: 105 patients aged >= 75 years with resected non-small cell lung cancer were matched with 105 younger patients by propensity score. Survival rates were calculated by the Kaplan-Meier method. The cumulative incidence functions of conditional survival rate according to the age of the patients were calculated by competing risk analysis.

Results: patients >= 75 years was associated with higher postoperative complication rate (p < 0.001), but similar perioperative death rate (p = 0.006). Patients >= 75 years were less likely to receive adjuvant chemotherapy (p < 0.001). The 5-year overall survival rates were 54.6% for patients >= 75 years and 74.1% for patients <75 years (p = 0.001). No difference was seen in disease-free survival rate (59.5% vs. 71.9% respectively = 0.117). The cumulative incidence functions of 5-year cancer-specific death were similar between the two groups (28.7% vs. 24.6% respectively, p = 0.106). The cumulative incidence functions of 5-year non-cancer-specific death was significantly higher in the elderly group (18.7% vs. 1.0%, p < 0.001).

Conclusions: VATS lobectomy for non-small-cell lung cancer in patients >= 75 years were feasible with increased morbidity but similar mortality. The resected elderly patients were more frequently associated with non-cancer-specific death.

语种: 英语
WOS记录号: WOS:000366805200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60247
Appears in Collections:北京大学第二临床医学院_胸外科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Ctr Mini Invas Thorac Surg, Dept Thorac Surg, Beijing 100044, Peoples R China

Recommended Citation:
Sui, Xizhao,Zhao, Hui,Wang, Jun,et al. Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study[J]. ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY,2015,21(6):529-535.
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