|Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study|
|Sui, Xizhao; Zhao, Hui; Wang, Jun; Yang, Feng; Yang, Fan; Li, Yun|
|关键词||lung cancer VATS lobectomy elderly|
|刊名||ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY|
|WOS标题词||Science & Technology|
|类目[WOS]||Cardiac & Cardiovascular Systems ; Surgery|
|研究领域[WOS]||Cardiovascular System & Cardiology ; Surgery|
|关键词[WOS]||LONG-TERM SURVIVAL ; PULMONARY RESECTION ; PREOPERATIVE ASSESSMENT ; THORACIC-SURGERY ; CO-MORBIDITY ; TASK-FORCE ; POPULATION ; DATABASE ; COMPLICATIONS ; MANAGEMENT|
Purpose: To analyze the short-term and long-term outcome of video-assisted thoracic surgery (VATS) lobectomy for elderly patients with non-small cell lung cancer.
Methods: 105 patients aged >= 75 years with resected non-small cell lung cancer were matched with 105 younger patients by propensity score. Survival rates were calculated by the Kaplan-Meier method. The cumulative incidence functions of conditional survival rate according to the age of the patients were calculated by competing risk analysis.
Results: patients >= 75 years was associated with higher postoperative complication rate (p < 0.001), but similar perioperative death rate (p = 0.006). Patients >= 75 years were less likely to receive adjuvant chemotherapy (p < 0.001). The 5-year overall survival rates were 54.6% for patients >= 75 years and 74.1% for patients <75 years (p = 0.001). No difference was seen in disease-free survival rate (59.5% vs. 71.9% respectively = 0.117). The cumulative incidence functions of 5-year cancer-specific death were similar between the two groups (28.7% vs. 24.6% respectively, p = 0.106). The cumulative incidence functions of 5-year non-cancer-specific death was significantly higher in the elderly group (18.7% vs. 1.0%, p < 0.001).
Conclusions: VATS lobectomy for non-small-cell lung cancer in patients >= 75 years were feasible with increased morbidity but similar mortality. The resected elderly patients were more frequently associated with non-cancer-specific death.
|作者单位||Peking Univ, Peoples Hosp, Ctr Mini Invas Thorac Surg, Dept Thorac Surg, Beijing 100044, Peoples R China|
|Sui, Xizhao,Zhao, Hui,Wang, Jun,et al. Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study[J]. ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY,2015,21(6):529-535.|
|APA||Sui, Xizhao,Zhao, Hui,Wang, Jun,Yang, Feng,Yang, Fan,&Li, Yun.(2015).Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study.ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY,21(6),529-535.|
|MLA||Sui, Xizhao,et al."Outcome of VATS Lobectomy for Elderly Non-Small Cell Lung Cancer: A Propensity Score-Matched Study".ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY 21.6(2015):529-535.|