An integrated map of genetic variation from 1,092 human genomes | |
Altshuler, David M.3; Durbin, Richard M.6; Abecasis, Goncalo R.7; Bentley, David R.8; Chakravarti, Aravinda9; Clark, Andrew G.10; Donnelly, Peter1,2; Eichler, Evan E.11,12; Flicek, Paul13; Gabriel, Stacey B.3; Gibbs, Richard A.14; Green, Eric D.; Hurles, Matthew E.6; Knoppers, Bartha M.15; Korbel, Jan O.16; Lander, Eric S.; Lee, Charles17; Lehrach, Hans19; Mardis, Elaine R.21; Marth, Gabor T.22; McVean, Gil A.1; Nickerson, Deborah A.23; Schmidt, Jeanette P.24; Sherry, Stephen T.25; Wang, Jun26; Wilson, Richard K.21; Gibbs, Richard A.; Dinh, Huyen14; Kovar, Christie14; Lee, Sandra14; Lewis, Lora14; Muzny, Donna14; Reid, Jeff14; Wang, Min14; Wang, Jun; Fang, Xiaodong26; Guo, Xiaosen26; Jian, Min26; Jiang, Hui26; Jin, Xin26; Li, Guoqing26; Li, Jingxiang26; Li, Yingrui26; Li, Zhuo26; Liu, Xiao26; Lu, Yao26; Ma, Xuedi26; Su, Zhe26; Tai, Shuaishuai26; Tang, Meifang26; Wang, Bo26; Wang, Guangbiao26; Wu, Honglong26; Wu, Renhua26; Yin, Ye26; Zhang, Wenwei26; Zhao, Jiao26; Zhao, Meiru26; Zheng, Xiaole26; Zhou, Yan26; Lander, Eric S.; Altshuler, David M.; Gabriel, Stacey B.; Gupta, Namrata3; Flicek, Paul; Clarke, Laura13; Leinonen, Rasko13; Smith, Richard E.13; Zheng-Bradley, Xiangqun13; Bentley, David R.; Grocock, Russell8; Humphray, Sean8; James, Terena8; Kingsbury, Zoya8; Lehrach, Hans; Sudbrak, Ralf19; Albrecht, Marcus W.29; Amstislavskiy, Vyacheslav S.19; Borodina, Tatiana A.29; Lienhard, Matthias19; Mertes, Florian19; Sultan, Marc19; Timmermann, Bernd19; Yaspo, Marie-Laure19; Sherry, Stephen T.; McVean, Gil A.; Mardis, Elaine R.; Wilson, Richard K.; Fulton, Lucinda21; Fulton, Robert21; Weinstock, George M.21; Durbin, Richard M.; Balasubramaniam, Senduran6; Burton, John6; Danecek, Petr6; Keane, Thomas M.6; Kolb-Kokocinski, Anja6; McCarthy, Shane6; Stalker, James6; Quail, Michael6; Schmidt, Jeanette P.; Davies, Christopher J.24; Gollub, Jeremy24; Webster, Teresa24; Wong, Brant24; Zhan, Yiping24; Auton, Adam30; Gibbs, Richard A.; Yu, Fuli14; Bainbridge, Matthew14; Challis, Danny14; Evani, Uday S.14; Lu, James14; Muzny, Donna; Nagaswamy, Uma14; Reid, Jeff; Sabo, Aniko14; Wang, Yi14; Yu, Jin14; Wang, Jun; Coin, Lachlan J. M.26; Fang, Lin26; Guo, Xiaosen; Jin, Xin; Li, Guoqing; Li, Qibin26; Li, Yingrui; Li, Zhenyu26; Lin, Haoxiang26; Liu, Binghang26; Luo, Ruibang26; Qin, Nan26; Shao, Haojing26; Wang, Bingqiang26; Xie, Yinlong26; Ye, Chen26; Yu, Chang26; Zhang, Fan26; Zheng, Hancheng26; Zhu, Hongmei26; Marth, Gabor T.; Garrison, Erik P.22; Kural, Deniz22; Lee, Wan-Ping22; Leong, Wen Fung22; Ward, Alistair N.22; Wu, Jiantao22; Zhang, Mengyao22; Lee, Charles; Griffin, Lauren17; Hsieh, Chih-Heng17; Mills, Ryan E.17; Shi, Xinghua17; von Grotthuss, Marcin17; Zhang, Chengsheng17; Daly, Mark J.3; DePristo, Mark A.3; Altshuler, David M.; Banks, Eric3; Bhatia, Gaurav3; Carneiro, Mauricio O.3; del Angel, Guillermo3; Gabriel, Stacey B.; Genovese, Giulio3; Gupta, Namrata; Handsaker, Robert E.3; Hartl, Chris3; Lander, Eric S.; McCarroll, Steven A.3; Nemesh, James C.3; Poplin, Ryan E.3; Schaffner, Stephen F.3; Shakir, Khalid3; Yoon, Seungtai C.32; Lihm, Jayon32; Makarov, Vladimir33; Jin, Hanjun35; Kim, Wook36; Kim, Ki Cheol36; Korbel, Jan O.; Rausch, Tobias16; Flicek, Paul; Beal, Kathryn13; Clarke, Laura; Cunningham, Fiona13; Herrero, Javier13; McLaren, William M.13; Ritchie, Graham R. S.13; Smith, Richard E.; Zheng-Bradley, Xiangqun; Clark, Andrew G.; Gottipati, Srikanth37; Keinan, Alon10; Rodriguez-Flores, Juan L.10; Sabeti, Pardis C.3,38,39; Grossman, Sharon R.3,38,39; Tabrizi, Shervin3; Tariyal, Ridhi3,38,39; Cooper, David N.40; Ball, Edward V.40; Stenson, Peter D.40; Bentley, David R.; Barnes, Bret41; Bauer, Markus8; Cheetham, R. Keira8; Cox, Tony8; Eberle, Michael8; Humphray, Sean; Kahn, Scott41; Murray, Lisa8; Peden, John8; Shaw, Richard8; Ye, Kai42; Batzer, Mark A.43; Konkel, Miriam K.43; Walker, Jerilyn A.43; MacArthur, Daniel G.44; Lek, Monkol44; Sudbrak, Ralf; Amstislavskiy, Vyacheslav S.; Herwig, Ralf19; Shriver, Mark D.45; Bustamante, Carlos D.46; Byrnes, Jake K.47; De la Vega, Francisco M.10; Gravel, Simon46; Kenny, Eimear E.46; Kidd, Jeffrey M.46; Lacroute, Phil46; Maples, Brian K.46; Moreno-Estrada, Andres46; Zakharia, Fouad46; Halperin, Eran48,49,50; Baran, Yael48; Craig, David W.51; Christoforides, Alexis51; Homer, Nils52; Izatt, Tyler51; Kurdoglu, Ahmet A.51; Sinari, Shripad A.51; Squire, Kevin53; Sherry, Stephen T.; Xiao, Chunlin25; Sebat, Jonathan54,55; Bafna, Vineet56; Ye, Kenny57; Burchard, Esteban G.58; Hernandez, Ryan D.58; Gignoux, Christopher R.58; Haussler, David59; Katzman, Sol J.59; Kent, W. James59; Howie, Bryan61; Ruiz-Linares, Andres62; Dermitzakis, Emmanouil T.63; Lappalainen, Tuuli63,64; Devine, Scott E.66; Liu, Xinyue66; Maroo, Ankit66; Tallon, Luke J.66; Rosenfeld, Jeffrey A.67; Michelson, Leslie P.67; Abecasis, Goncalo R.; Kang, Hyun Min7; Anderson, Paul7; Angius, Andrea69; Bigham, Abigail70; Blackwell, Tom7; Busonero, Fabio7,69; Cucca, Francesco69,71; Fuchsberger, Christian7; Jones, Chris72; Jun, Goo7; Li, Yun73; Lyons, Robert74; Maschio, Andrea7,69; Porcu, Eleonora7,69; Reinier, Fred72; Sanna, Serena69; Schlessinger, David75; Sidore, Carlo7,69; Tan, Adrian7; Trost, Mary Kate7; Awadalla, Philip76; Hodgkinson, Alan76; Lunter, Gerton1; McVean, Gil A.; Marchini, Jonathan L.1,2; Myers, Simon1,2; Churchhouse, Claire2; Delaneau, Olivier2; Gupta-Hinch, Anjali1; Iqbal, Zamin1; Mathieson, Iain1; Rimmer, Andy1; Xifara, Dionysia K.1,2; Oleksyk, Taras K.77; Fu, Yunxin78; Liu, Xiaoming78; Xiong, Momiao78; Jorde, Lynn79; Witherspoon, David79; Xing, Jinchuan80; Eichler, Evan E.; Browning, Brian L.81; Alkan, Can23; Hajirasouliha, Iman83; Hormozdiari, Fereydoun23; Ko, Arthur23; Sudmant, Peter H.23; Mardis, Elaine R.; Chen, Ken84; Chinwalla, Asif21; Ding, Li21; Dooling, David21; Koboldt, Daniel C.21; McLellan, Michael D.21; Wallis, John W.21; Wendl, Michael C.21; Zhang, Qunyuan21; Durbin, Richard M.; Hurles, Matthew E.; Tyler-Smith, Chris6; Albers, Cornelis A.85,86; Ayub, Qasim6; Balasubramaniam, Senduran; Chen, Yuan6; Coffey, Alison J.6; Colonna, Vincenza6; Danecek, Petr; Huang, Ni6; Jostins, Luke6; Keane, Thomas M.; Li, Heng3; McCarthy, Shane; Scally, Aylwyn6; Stalker, James; Walter, Klaudia6; Xue, Yali6; Zhang, Yujun6; Gerstein, Mark B.88,89; Abyzov, Alexej88; Balasubramanian, Suganthi90; Chen, Jieming88; Clarke, Declan91; Fu, Yao88; Habegger, Lukas88; Harmanci, Arif O.88; Jin, Mike90; Khurana, Ekta90; Mu, Xinmeng Jasmine88; Sisu, Cristina88; Li, Yingrui; Luo, Ruibang; Zhu, Hongmei; Lee, Charles; Griffin, Lauren; Hsieh, Chih-Heng; Mills, Ryan E.; Shi, Xinghua; von Grotthuss, Marcin; Zhang, Chengsheng; Marth, Gabor T.; Garrison, Erik P.; Kural, Deniz; Lee, Wan-Ping; Ward, Alistair N.; Wu, Jiantao; Zhang, Mengyao; McCarroll, Steven A.; Altshuler, David M.; Banks, Eric; del Angel, Guillermo; Genovese, Giulio; Handsaker, Robert E.; Hartl, Chris; Nemesh, James C.; Shakir, Khalid; Yoon, Seungtai C.; Lihm, Jayon; Makarov, Vladimir; Degenhardt, Jeremiah10; Flicek, Paul; Clarke, Laura; Smith, Richard E.; Zheng-Bradley, Xiangqun; Korbel, Jan O.; Rausch, Tobias; Stuetz, Adrian M.16; Bentley, David R.; Barnes, Bret; Cheetham, R. Keira; Eberle, Michael; Humphray, Sean; Kahn, Scott; Murray, Lisa; Shaw, Richard; Ye, Kai; Batzer, Mark A.; Konkel, Miriam K.; Walker, Jerilyn A.; Lacroute, Phil; Craig, David W.; Homer, Nils; Church, Deanna25; Xiao, Chunlin; Sebat, Jonathan; Bafna, Vineet; Michaelson, Jacob J.92; Ye, Kenny; Devine, Scott E.; Liu, Xinyue; Maroo, Ankit; Tallon, Luke J.; Lunter, Gerton; McVean, Gil A.; Iqbal, Zamin; Witherspoon, David; Xing, Jinchuan; Eichler, Evan E.; Alkan, Can; Hajirasouliha, Iman; Hormozdiari, Fereydoun; Ko, Arthur; Sudmant, Peter H.; Chen, Ken; Chinwalla, Asif; Ding, Li; McLellan, Michael D.; Wallis, John W.; Hurles, Matthew E.; Ben Blackburne6; Li, Heng; Lindsay, Sarah J.6; Ning, Zemin6; Scally, Aylwyn; Walter, Klaudia; Zhang, Yujun; Gerstein, Mark B.; Abyzov, Alexej; Chen, Jieming; Clarke, Declan; Khurana, Ekta; Mu, Xinmeng Jasmine; Sisu, Cristina; Gibbs, Richard A.; Yu, Fuli; Bainbridge, Matthew; Challis, Danny; Evani, Uday S.; Kovar, Christie; Lewis, Lora; Lu, James; Muzny, Donna; Nagaswamy, Uma; Reid, Jeff; Sabo, Aniko; Yu, Jin; Guo, Xiaosen; Li, Yingrui; Wu, Renhua; Marth, Gabor T.; Garrison, Erik P.2,22; Leong, Wen Fung; Ward, Alistair N.; del Angel, Guillermo; DePristo, Mark A.; Gabriel, Stacey B.; Gupta, Namrata; Hartl, Chris; Poplin, Ryan E.; Clark, Andrew G.; Rodriguez-Flores, Juan L.; Flicek, Paul; Clarke, Laura; Smith, Richard E.; Zheng-Bradley, Xiangqun; MacArthur, Daniel G.; Bustamante, Carlos D.; Gravel, Simon; Craig, David W.; Christoforides, Alexis; Homer, Nils; Izatt, Tyler; Sherry, Stephen T.; Xiao, Chunlin; Dermitzakis, Emmanouil T.; Abecasis, Goncalo R.; Kang, Hyun Min; McVean, Gil A.; Mardis, Elaine R.; Dooling, David; Fulton, Lucinda; Fulton, Robert; Koboldt, Daniel C.; Durbin, Richard M.; Balasubramaniam, Senduran; Keane, Thomas M.; McCarthy, Shane; Stalker, James; Gerstein, Mark B.; Balasubramanian, Suganthi; Habegger, Lukas; Garrison, Erik P.; Gibbs, Richard A.; Bainbridge, Matthew; Muzny, Donna; Yu, Fuli; Yu, Jin; del Angel, Guillermo; Handsaker, Robert E.; Makarov, Vladimir; Rodriguez-Flores, Juan L.; Jin, Hanjun; Kim, Wook; Kim, Ki Cheol; Flicek, Paul; Beal, Kathryn; Clarke, Laura13; Cunningham, Fiona; Herrero, Javier; McLaren, William M.; Ritchie, Graham R. S.; Zheng-Bradley, Xiangqun; Tabrizi, Shervin; MacArthur, Daniel G.; Lek, Monkol; Bustamante, Carlos D.; De la Vega, Francisco M.; Craig, David W.; Kurdoglu, Ahmet A.; Lappalainen, Tuuli; Rosenfeld, Jeffrey A.; Michelson, Leslie P.67,68; Awadalla, Philip; Hodgkinson, Alan; McVean, Gil A.; Chen, Ken; Tyler-Smith, Chris; Chen, Yuan; Colonna, Vincenza; Frankish, Adam6; Harrow, Jennifer6; Xue, Yali; Gerstein, Mark B.; Abyzov, Alexej; Balasubramanian, Suganthi; Chen, Jieming; Clarke, Declan; Fu, Yao; Harmanci, Arif O.; Jin, Mike; Khurana, Ekta; Mu, Xinmeng Jasmine; Sisu, Cristina; Gibbs, Richard A.; Fowler, Gerald14; Hale, Walker14; Kalra, Divya14; Kovar, Christie; Muzny, Donna; Reid, Jeff; Wang, Jun; Guo, Xiaosen; Li, Guoqing; Li, Yingrui; Zheng, Xiaole; Altshuler, David M.; Flicek, Paul; Clarke, Laura; Barker, Jonathan13; Kelman, Gavin13; Kulesha, Eugene13; Leinonen, Rasko13; McLaren, William M.; Radhakrishnan, Rajesh13; Roa, Asier13; Smirnov, Dmitriy13; Smith, Richard E.; Streeter, Ian13; Toneva, Iliana13; Vaughan, Brendan13; Zheng-Bradley, Xiangqun; Bentley, David R.; Cox, Tony; Humphray, Sean; Kahn, Scott; Sudbrak, Ralf; Albrecht, Marcus W.; Lienhard, Matthias; Craig, David W.; Izatt, Tyler; Kurdoglu, Ahmet A.; Sherry, Stephen T.; Ananiev, Victor25; Belaia, Zinaida25; Beloslyudtsev, Dimitriy25; Bouk, Nathan25; Chen, Chao25; Church, Deanna; Cohen, Robert25; Cook, Charles25; Garner, John25; Hefferon, Timothy25; Kimelman, Mikhail25; Liu, Chunlei25; Lopez, John25; Meric, Peter25; O′ Sullivan, Chris; Ostapchuk, Yuri25; Phan, Lon25; Ponomarov, Sergiy25; Schneider, Valerie25; Shekhtman, Eugene25; Sirotkin, Karl25; Slotta, Douglas25; Xiao, Chunlin; Zhang, Hua25; Haussler, David; Abecasis, Goncalo R.; McVean, Gil A.; Alkan, Can; Ko, Arthur; Dooling, David; Durbin, Richard M.; Balasubramaniam, Senduran; Keane, Thomas M.; McCarthy, Shane; Stalker, James; Chakravarti, Aravinda; Knoppers, Bartha M.; Abecasis, Goncalo R.; Barnes, Kathleen C.94; Beiswanger, Christine95; Burchard, Esteban G.; Bustamante, Carlos D.; Cai, Hongyu26; Cao, Hongzhi26; Durbin, Richard M.; Gharani, Neda95; Gibbs, Richard A.; Gignoux, Christopher R.; Gravel, Simon; Henn, Brenna46; Jones, Danielle37; Jorde, Lynn; Kaye, Jane S.96; Keinan, Alon; Kent, Alastair97; Kerasidou, Angeliki1; Li, Yingrui; Mathias, Rasika98; McVean, Gil A.; Moreno-Estrada, Andres; Ossorio, Pilar N.99,100; Parker, Michael101; Reich, David5; Rotimi, Charles N.93; Royal, Charmaine D.102; Sandoval, Karla46; Su, Yeyang26; Sudbrak, Ralf; Tian, Zhongming26; Timmermann, Bernd; Tishkoff, Sarah103; Toji, Lorraine H.95; Tyler-Smith, Chris; Via, Marc104; Wang, Yuhong26; Yang, Huanming26; Yang, Ling26; Zhu, Jiayong26; Bodmer, Walter105; Bedoya, Gabriel106; Ruiz-Linares, Andres; Ming, Cai Zhi26; Yang, Gao107; You, Chu Jia108,109; Peltonen, Leena; Garcia-Montero, Andres110,111; Orfao, Alberto110,112,113; Dutil, Julie114; Martinez-Cruzado, Juan C.77; Oleksyk, Taras K.; Brooks, Lisa D.; Felsenfeld, Adam L.; McEwen, Jean E.; Clemm, Nicholas C.; Duncanson, Audrey115; Dunn, Michael115; Green, Eric D.; Guyer, Mark S.; Peterson, Jane L.; Abecasis, Goncalo R.; Auton, Adam; Brooks, Lisa D.; DePristo, Mark A.; Durbin, Richard M.; Handsaker, Robert E.; Kang, Hyun Min; Marth, Gabor T.; McVean, Gil A.; 1000 Genomes Project Consortium | |
Source Publication | NATURE
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2012-11-01 | |
Volume | 491Issue:7422Pages:56-65 |
Indexed By | SCI |
Abstract | By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes of 1,092 individuals from 14 populations, constructed using a combination of low-coverage whole-genome and exome sequencing. By developing methods to integrate information across several algorithms and diverse data sources, we provide a validated haplotype map of 38 million single nucleotide polymorphisms, 1.4 million short insertions and deletions, and more than 14,000 larger deletions. We show that individuals from different populations carry different profiles of rare and common variants, and that low-frequency variants show substantial geographic differentiation, which is further increased by the action of purifying selection. We show that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites. This resource, which captures up to 98% of accessible single nucleotide polymorphisms at a frequency of 1% in related populations, enables analysis of common and low-frequency variants in individuals from diverse, including admixed, populations. |
Subject Area | 临床医学 |
Subtype | Article |
DOI | 10.1038/nature11632 |
WOS Headings | Science & Technology |
Language | 英语 |
Funding Organization | Wellcome Trust ; Medical Research Council ; British Heart Foundation ; National Basic Research Program of China (973 program) ; Chinese 863 program ; National Natural Science Foundation of China ; Shenzhen Key Laboratory of Transomics Biotechnologies ; Shenzhen Municipal Government of China ; Guangdong Innovative Research Team Program ; BMBF ; Max Planck Society ; Swiss National Science Foundation ; Swiss National Science Foundation NCCR &prime ; Frontiers in Genetics&prime ; grant ; Louis Jeantet Foundation ; Biotechnology and Biological Sciences Research Council (BBSRC) ; German Research Foundation ; Netherlands Organization for Scientific Research VENI ; Beatriu de Pinos Program ; Israeli Science Foundation ; Genome Quebec and the Ministry of Economic Development, Innovation and Trade ; National Institutes of Health (NIH) ; BAA-NIAID-DAIT-NIHAI |
WOS Research Area | Science & Technology - Other Topics |
WOS Subject | Multidisciplinary Sciences |
WOS Keyword | COPY NUMBER VARIATION ; POPULATION-SCALE ; WIDE ASSOCIATION ; CODING VARIATION ; RARE ; VARIANTS ; DISEASE ; LOCI ; DISCOVERY ; HISTORY |
WOS ID | WOS:000310434500030 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.bjmu.edu.cn/handle/400002259/60248 |
Collection | 北京大学深圳医院 北京大学第一临床医学院_消化科 北京大学第二临床医学院_中心实验室 北京大学第三临床医学院_放射科 北京大学第三临床医学院_医学工程处 北京大学精神卫生研究所_精神科 |
Affiliation | 1.Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark 2.Yale Univ, Dept Comp Sci, New Haven, CT 06520 USA 3.Alacris Theranost GmbH, D-14195 Berlin, Germany 4.Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA 5.Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA 6.Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA 7.Dankook Univ, Dept Nanobiomed Sci, Cheonan 330714, South Korea 8.Yale Univ, Dept Chem, New Haven, CT 06520 USA 9.Coriell Inst Med Res, Camden, NJ 08103 USA 10.Genet Alliance, London N1 3QP, England 11.Dankook Univ, Dept Biol Sci, Cheonan 330714, South Korea 12.Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA 13.Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USA 14.Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA 15.Harvard Univ, Ctr Syst Biol, Cambridge, MA 02138 USA 16.Illumina Inc, San Diego, CA 92122 USA 17.Stanford Univ, Dept Genet, Stanford, CA 94305 USA 18.Ancestry Com, San Francisco, CA 94107 USA 19.Univ Antioquia, Inst Biol, Mol Genet Lab, Medellin, Colombia 20.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Peoples R China 21.Peking Union Med Coll, Kunming 650118, Peoples R China 22.Univ Salamanca, Cytometry Serv, Salamanca 37007, Spain 23.Univ Salamanca, Dept Med, Salamanca 37007, Spain 24.Ponce Sch Med & Hlth Sci, Ponce, PR 00716 USA 25.Wellcome Trust Res Labs, London NW1 2BE, England 26.Life Technol, Beverly, MA 01915 USA 27.Univ Cambridge, Dept Haematol, Cambridge CB2 1TN, England 28.Natl Hlth Serv Blood & Transplant, Cambridge CB2 1TN, England 29.Tel Aviv Univ, Dept Microbiol, IL-69978 Tel Aviv, Israel 30.Int Comp Sci Inst, Berkeley, CA 94704 USA 31.Translat Genom Res Inst, Phoenix, AZ 85004 USA 32.Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England 33.Univ Oxford, Dept Stat, Oxford OX1 3TG, England 34.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA 35.Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA 36.Harvard Univ, Sch Med, Dept Genet, Cambridge, MA 02142 USA 37.Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England 38.Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA 39.Illumina United Kingdom, Near Saffron Walden CB10 1XL, Essex, England 40.Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA 41.Cornell Univ, Ctr Comparat & Populat Genom, Ithaca, NY 14850 USA 42.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA 43.Howard Hughes Med Inst, Seattle, WA 98195 USA 44.McGill Univ, Ctr Genom & Policy, Montreal, PQ H3A 1A4, Canada 45.Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA 46.Harvard Univ, Sch Med, Boston, MA 02115 USA 47.European Bioinformat Inst, Cambridge CB10 1SD, England 48.Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA 49.European Mol Biol Lab, Genome Biol Res Unit, D-69117 Heidelberg, Germany 50.Max Planck Inst Mol Genet, D-14195 Berlin, Germany 51.Dahlem Ctr Genome Res & Med Syst Biol, D-14195 Berlin, Germany 52.Washington Univ, Sch Med, Genome Ctr, St Louis, MO 63108 USA 53.Boston Coll, Dept Biol, Chestnut Hill, MA 02467 USA 54.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA 55.Affymetrix Inc, Santa Clara, CA 95051 USA 56.US Natl Inst Hlth, Natl Ctr Biotechnol Informat, Bethesda, MD 20892 USA 57.BGI Shenzhen, Shenzhen 518083, Peoples R China 58.Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark 59.Albert Einstein Coll Med, Dept Genet, Bronx, NY 10461 USA 60.Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA 61.Mt Sinai Sch Med, Seaver Autism Ctr, New York, NY 10029 USA 62.Cornell Univ, Dept Biol Stat & Computat Biol, Ithaca, NY 14853 USA 63.Natl Res Council CNR, Inst Genet & Biophys, I-80125 Naples, Italy 64.Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA 65.Cardiff Univ, Sch Med, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales 66.Leiden Univ, Med Ctr, Dept Med Stat & Bioinformat, Mol Epidemiol Sect, NL-2333 ZA Leiden, Netherlands 67.Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA 68.Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA 69.Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA 70.Tel Aviv Univ, Blavatnik Sch Comp Sci, IL-69978 Tel Aviv, Israel 71.Univ Calif Los Angeles, David Geffen Sch ofMedicine, Dept Human Genet, Los Angeles, CA 90024 USA 72.Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA 73.Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA 74.Univ Calif San Diego, Dept Comp Sci, La Jolla, CA 92093 USA 75.Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA 76.Univ Calif San Francisco, Dept Bioengn & Therapeut Sci & Med, San Francisco, CA 94158 USA 77.Univ Calif Santa Cruz, Ctr Biomol Sci & Engn, Santa Cruz, CA 95064 USA 78.Howard Hughes Med Inst, Santa Cruz, CA 95064 USA 79.Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA 80.UCL, Dept Genet Evolut & Environm, London WC1E 6BT, England 81.Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland 82.Univ Geneva, Inst Genet & Genom Geneva iGE3, CH-1211 Geneva, Switzerland 83.Swiss Inst Bioinformat, CH-1211 Geneva, Switzerland 84.Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA 85.Univ Med & Dent New Jersey, IST High Performance & Res Comp, Newark, NJ 07107 USA 86.Amer Museum Nat Hist, Dept Invertebrate Zool, New York, NY 10024 USA 87.CNR, Ist Ric Genet & Biomed, I-09042 Cagliari, Italy 88.Univ Michigan, Dept Anthropol, Ann Arbor, MI 48109 USA 89.Univ Sassari, Dipartimento Sci Biomed, I-07100 Sassari, Italy 90.Ctr Adv Studies Res & Dev Sardinia CRS4, AGCT Program, I-09010 Pula, Italy 91.Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA 92.Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA 93.Bilkent Univ, Dept Comp Engn, TR-06800 Bilkent, Turkey 94.Simon Fraser Univ, Dept Comp Sci, Burnaby, BC V5A 1S6, Canada 95.Univ Michigan, Sequencing Core, Ann Arbor, MI 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Recommended Citation GB/T 7714 | Altshuler, David M.,Durbin, Richard M.,Abecasis, Goncalo R.,et al. An integrated map of genetic variation from 1,092 human genomes[J]. NATURE,2012,491(7422):56-65. |
APA | Altshuler, David M..,Durbin, Richard M..,Abecasis, Goncalo R..,Bentley, David R..,Chakravarti, Aravinda.,...&1000 Genomes Project Consortium.(2012).An integrated map of genetic variation from 1,092 human genomes.NATURE,491(7422),56-65. |
MLA | Altshuler, David M.,et al."An integrated map of genetic variation from 1,092 human genomes".NATURE 491.7422(2012):56-65. |
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