IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
The effects of temperature, pH, and salinity on the growth and dimorphism of Penicillium marneffei
Cao, Cunwei; Li, Ruoyu; Wan, Zhe; Liu, Wei; Wang, Xiaohong; Qiao, Jianjun; Wang, Duanli; Bulmer, Glenn; Calderone, Richard
关键词Penicillium marneffei physiology temperature pH salinity
刊名MEDICAL MYCOLOGY
2007
DOI10.1080/13693780701358600
45期:5页:401-407
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology ; Veterinary Sciences
研究领域[WOS]Mycology ; Veterinary Sciences
关键词[WOS]HISTOPLASMA-CAPSULATUM ; CANNOMYS-BADIUS ; SOUTHEAST-ASIA ; INFECTION ; HOMOLOG ; SOIL
英文摘要

Penicillium marneffei is an important thermal dimorphic fungus that is endemic to Southeast Asia and China and causes penicilliosis, an AIDS- defining disease. Dimorphic switching is considered an important growth characteristic associated with its pathogenicity. In recent years, the molecular mechanisms underlying both dimorphic switching and monomorphic growth have been studied. However, little is known about the physical and chemical factors that impact either dimorphic switching or monomorphic growth of this organism. Further, the natural history of the disease is unclear. Our experiments focus upon the effects of temperature, pH and salinity on both growth phases of P. marneffei. We compared 11 isolates of P. marneffei and found that all could grow at a wide temperature range ( 8.0 - 39.88 degrees C), but growth was dramatically inhibited at 40 degrees C. The morphological switch from hyphae to yeast growth was initiated at 32 degrees C. However, the sensitivity to elevated temperatures during this transition varied among isolates. Both hyphae and yeast growth forms grew much better at acidic ( pH 5, 6) and neutral pH than at alkaline conditions. While similar sensitivities were observed at high concentrations of NaCl and CaCl2, in general, yeast cells displayed a greater sensitivity to both compounds. Our data demonstrate that isolate differences occur in growth patterns. Importantly, the growth requirements defined in our study may shed light on the environmental conditions that favor its survival, a subject that is not completely resolved in the current literature.

语种英语
WOS记录号WOS:000248752600003
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60251
Collection北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Hosp 1, Res Ctr Med Mycol, Beijing 100034, Peoples R China
2.Georgetown Univ, Med Ctr, Dept Microbiol & Immunol, Washington, DC 20007 USA
Recommended Citation
GB/T 7714
Cao, Cunwei,Li, Ruoyu,Wan, Zhe,et al. The effects of temperature, pH, and salinity on the growth and dimorphism of Penicillium marneffei[J]. MEDICAL MYCOLOGY,2007,45(5):401-407.
APA Cao, Cunwei.,Li, Ruoyu.,Wan, Zhe.,Liu, Wei.,Wang, Xiaohong.,...&Calderone, Richard.(2007).The effects of temperature, pH, and salinity on the growth and dimorphism of Penicillium marneffei.MEDICAL MYCOLOGY,45(5),401-407.
MLA Cao, Cunwei,et al."The effects of temperature, pH, and salinity on the growth and dimorphism of Penicillium marneffei".MEDICAL MYCOLOGY 45.5(2007):401-407.
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