IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
N-terminal-pro-B-type natriuretic peptide (NT-proBNP): Reference range for Chinese apparently healthy people and clinical performance in Chinese elderly patients with heart failure
Shi, XM; Xu, GB; Xia, TA; Song, YX; Lin, Q
关键词natriuretic peptides heart failure
刊名CLINICA CHIMICA ACTA
2005-10-01
DOI10.1016/j.cccn.2005.04.033
360期:1-2页:122-127
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]DIAGNOSTIC-ACCURACY ; BNP ; ASSAY
英文摘要

Background: N-terminal-pro-B-type natriuretic peptide (NT-proBNP) has been found to be a useful marker for the diagnosis of heart failure (HF) and left ventricular systolic dysfunction. We established a reference range for Chinese apparently healthy people based on age and gender and evaluated the clinical performance of NT-proBNP in the diagnosis of asymptomatic and symptomatic HF.

Methods: A group of 442 apparently healthy subjects were enrolled for reference range study. For the clinical performance study, serum NT-proBNP and clinical data were analyzed in 111 elderly patients with HF and 60 normal elderly controls. Serum NT-proBNP was measured by the Roche Elecsys 2010 immunoassay analyzer.

Results: NT-proBNP reference range in Chinese people based on age and gender was <83.72 ng/l for men and <131.6 ng/l for women aged :560 years, and <158.17 ng/1 for men and <205.54 ng/1 for women aged >60 years, which were lower than those for western countries. NT-proBNP had a close correlation with New York Heart Association (NYHA) classification (r=0.818) and LVEF (r = -0.636). The ROC curve analysis revealed an AUC of 0.921 for the diagnosis of HF, 0.840 for asymptomatic HF (NYHA 1) and 0.951 for symptomatic HF (NYHA II-IV). The optimal cutoff values for detecting HF, asymptomatic HF and symptomatic HF were 102.2, 102.2, and 204.8 ng/l, respectively. NT-proBNP had high positive predictive value (PPV) for the diagnosis of HF (96.8%), asymptomatic HF (90.3%) and symptomatic HF (90.9%), but low negative predictive value (NPV) for diagnosing HF and asymptomatic HF (74.0% and 78.1 %, respectively) except symptomatic HF (93.3%).

Conclusions: Chinese people have lower reference range of serum NT-proBNP. NT-proBNP assay has a good clinical performance for the diagnosis of symptomatic HF but is not suitable as a screening test for HF. (c) 2005 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000232682200015
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60257
专题北京大学第一临床医学院
作者单位Peking Univ, Hosp 1, Dept Lab Med, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Shi, XM,Xu, GB,Xia, TA,et al. N-terminal-pro-B-type natriuretic peptide (NT-proBNP): Reference range for Chinese apparently healthy people and clinical performance in Chinese elderly patients with heart failure[J]. CLINICA CHIMICA ACTA,2005,360(1-2):122-127.
APA Shi, XM,Xu, GB,Xia, TA,Song, YX,&Lin, Q.(2005).N-terminal-pro-B-type natriuretic peptide (NT-proBNP): Reference range for Chinese apparently healthy people and clinical performance in Chinese elderly patients with heart failure.CLINICA CHIMICA ACTA,360(1-2),122-127.
MLA Shi, XM,et al."N-terminal-pro-B-type natriuretic peptide (NT-proBNP): Reference range for Chinese apparently healthy people and clinical performance in Chinese elderly patients with heart failure".CLINICA CHIMICA ACTA 360.1-2(2005):122-127.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shi, XM]的文章
[Xu, GB]的文章
[Xia, TA]的文章
百度学术
百度学术中相似的文章
[Shi, XM]的文章
[Xu, GB]的文章
[Xia, TA]的文章
必应学术
必应学术中相似的文章
[Shi, XM]的文章
[Xu, GB]的文章
[Xia, TA]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。