北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 期刊论文
学科主题: 临床医学
题名:
N-terminal-pro-B-type natriuretic peptide (NT-proBNP): Reference range for Chinese apparently healthy people and clinical performance in Chinese elderly patients with heart failure
作者: Shi, XM; Xu, GB; Xia, TA; Song, YX; Lin, Q
关键词: natriuretic peptides ; heart failure
刊名: CLINICA CHIMICA ACTA
发表日期: 2005-10-01
DOI: 10.1016/j.cccn.2005.04.033
卷: 360, 期:1-2, 页:122-127
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: DIAGNOSTIC-ACCURACY ; BNP ; ASSAY
英文摘要:

Background: N-terminal-pro-B-type natriuretic peptide (NT-proBNP) has been found to be a useful marker for the diagnosis of heart failure (HF) and left ventricular systolic dysfunction. We established a reference range for Chinese apparently healthy people based on age and gender and evaluated the clinical performance of NT-proBNP in the diagnosis of asymptomatic and symptomatic HF.

Methods: A group of 442 apparently healthy subjects were enrolled for reference range study. For the clinical performance study, serum NT-proBNP and clinical data were analyzed in 111 elderly patients with HF and 60 normal elderly controls. Serum NT-proBNP was measured by the Roche Elecsys 2010 immunoassay analyzer.

Results: NT-proBNP reference range in Chinese people based on age and gender was <83.72 ng/l for men and <131.6 ng/l for women aged :560 years, and <158.17 ng/1 for men and <205.54 ng/1 for women aged >60 years, which were lower than those for western countries. NT-proBNP had a close correlation with New York Heart Association (NYHA) classification (r=0.818) and LVEF (r = -0.636). The ROC curve analysis revealed an AUC of 0.921 for the diagnosis of HF, 0.840 for asymptomatic HF (NYHA 1) and 0.951 for symptomatic HF (NYHA II-IV). The optimal cutoff values for detecting HF, asymptomatic HF and symptomatic HF were 102.2, 102.2, and 204.8 ng/l, respectively. NT-proBNP had high positive predictive value (PPV) for the diagnosis of HF (96.8%), asymptomatic HF (90.3%) and symptomatic HF (90.9%), but low negative predictive value (NPV) for diagnosing HF and asymptomatic HF (74.0% and 78.1 %, respectively) except symptomatic HF (93.3%).

Conclusions: Chinese people have lower reference range of serum NT-proBNP. NT-proBNP assay has a good clinical performance for the diagnosis of symptomatic HF but is not suitable as a screening test for HF. (c) 2005 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000232682200015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60257
Appears in Collections:北京大学第一临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 1, Dept Lab Med, Beijing 100034, Peoples R China

Recommended Citation:
Shi, XM,Xu, GB,Xia, TA,et al. N-terminal-pro-B-type natriuretic peptide (NT-proBNP): Reference range for Chinese apparently healthy people and clinical performance in Chinese elderly patients with heart failure[J]. CLINICA CHIMICA ACTA,2005,360(1-2):122-127.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, XM]'s Articles
[Xu, GB]'s Articles
[Xia, TA]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, XM]‘s Articles
[Xu, GB]‘s Articles
[Xia, TA]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace