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学科主题: 口腔医学
题名:
Pregabalin Suppresses Nociceptive Behavior and Central Sensitization in a Rat Trigeminal Neuropathic Pain Model
作者: Cao, Ye1,2; Wang, Hua2; Chiang, Chen-Yu2; Dostrovsky, Jonathan O.2,3; Sessle, Barry J.2,3
关键词: Pregabalin ; allodynia ; central sensitization ; trigeminal neuropathic pain
刊名: JOURNAL OF PAIN
发表日期: 2013-02-01
DOI: 10.1016/j.jpain.2012.11.005
卷: 14, 期:2, 页:193-204
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MEDULLARY DORSAL-HORN ; SPINAL SUBNUCLEUS CAUDALIS ; PLACEBO-CONTROLLED TRIAL ; INFERIOR ALVEOLAR NERVE ; MECHANICAL ALLODYNIA ; INFRAORBITAL NERVE ; GLUTAMATE RELEASE ; OROFACIAL PAIN ; GABAPENTIN ; NEURONS
英文摘要:

The aim of this study was to determine whether pregabalin affects nociceptive behavior and central sensitization in a trigeminal neuropathic pain model. A partial infraorbital nerve transection (p-IONX) or sham operation was performed in adult male rats. Nociceptive withdrawal thresholds were tested with von Frey filaments applied to the bilateral vibrissal pads pre- and postoperatively. On postoperative day 7, the behavioral assessment was conducted before and at 30, 60, 120, and 180 minutes after and 24 hours after pregabalin (.1, 1, 10, 100 mg/kg intraperitoneally) or saline injection. The effects of pregabalin or saline were also examined on the mechanoreceptive field and response properties of nociceptive neurons recorded in the medullary dorsal horn at postoperative days 7 to 10. Reduced with-drawal thresholds reflecting bilateral mechanical allodynia were observed in p-IONX rats until postoperative day 28, but not in sham-operated rats. At postoperative day 7, pregabalin significantly and dose-dependently reversed the reduced mechanical withdrawal thresholds in p-IONX rats. Pregabalin also attenuated central sensitization of the neurons, as reflected in reversal of their reduced activation threshold, increased responses to pinch/pressure, and enhanced stimulus-response function. This study provides the first documentation that pregabalin attenuates the mechanical allodynia and central sensitization that characterize this trigeminal neuropathic pain model, and supports its clinical use for treating craniofacial neuropathic pain.

Perspective: Trigeminal nerve injury in rats produced facial mechanical hypersensitivity and trigeminal central sensitization of medullary dorsal horn neurons that were markedly attenuated by systemically administered pregabalin, suggesting its potential clinical utility for orofacial neuropathic pain. (C) 2013 by the American Pain Society

语种: 英语
所属项目编号: 82831 ; DE04786
项目资助者: Pfizer Canada ; Canadian Institutes of Health Research MOP grant ; US National Institutes of Health grant
WOS记录号: WOS:000314856600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60261
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Univ Toronto, Fac Dent, Toronto, ON M5G 1G6, Canada
2.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China
3.Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5G 1G6, Canada

Recommended Citation:
Cao, Ye,Wang, Hua,Chiang, Chen-Yu,et al. Pregabalin Suppresses Nociceptive Behavior and Central Sensitization in a Rat Trigeminal Neuropathic Pain Model[J]. JOURNAL OF PAIN,2013,14(2):193-204.
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