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学科主题: 药物依赖
题名:
THE EFFECT OF NUCLEUS ACCUMBENS LESIONS ON APPETITE, SEXUAL FUNCTION, AND NICOTINE DEPENDENCE IN RECOVERING HEROIN ADDICTS
作者: Wang, Yarong1; Zhu, Jia1; Chen, Ling2; Liu, Yijun3; Li, Qiang1; Yang, Weichuan1; Li, Wei1; Zhao, Liyan1,4; Gold, Mark S.3; Sun, Jifeng5; Wang, Wei1
关键词: Nucleus accumbens (NAc) ; Heroin dependence ; Human reward behavior
刊名: TRANSLATIONAL NEUROSCIENCE
发表日期: 2013-12-01
DOI: 10.2478/s13380-013-0146-x
卷: 4, 期:4, 页:419-428
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: FAGERSTROM TOLERANCE QUESTIONNAIRE ; VENTRAL TEGMENTAL AREA ; IN-VIVO MICRODIALYSIS ; DOPAMINE RELEASE ; MALE-RATS ; NEURONAL RESPONSES ; OPIOID RECEPTORS ; SELF-STIMULATION ; DRUG-ABUSE ; BEHAVIOR
英文摘要:

The nucleus accumbens (NAc) is a key part of the neural circuitry that creates reward, pleasure and motivation that facilitates human feeding, sexual and smoking behaviors. In the brain reward system, the NAc is a crucial component responsible for natural and drug-induced reinforcement behaviors. Yet it is unclear whether NAc is indispensible for all reward behaviors in human beings. The present study aimed to investigate the long-term effects of NAc ablation on sexual function, appetite, and nicotine dependence level in chronic heroin users. Eighteen former heroin-dependent patients (male) with bilateral NAc ablation via stereotactic radiofrequency surgery for alleviating drug psychological dependence were recruited. Their postoperative time ranged from 12 to 103 months. All subjects received MRI scans for assessing the accuracy of the lesion site. Evaluation of appetite, sexual function, and nicotine dependence were measured using the Simplified Nutrition Appetite Questionnaire, the Brief Sexual Function Inventory, and the Fagerstrom Test for Nicotine Dependence, respectively. After precluding the potential confounding variables, such as drug use (dosage and duration), post-operation duration, age, body-weight, marital status and education level, ANOVA with repeated measures revealed that the NAc ablation improved the patients′ appetite, sexual drive and sexual satisfaction. Yet there was no change in male erectile function, ejaculatory function, or nicotine dependence levels compared to the preoperative. These may suggest that although NAc is a key part of the neural circuitry, the NAc surgical lesions left the fundamental aspects of natural and drug-induced reinforcement and motivation almost intact.

语种: 英语
所属项目编号: 30870685 ; 81071143 ; 81071142 ; 2008k12-02 ; 2009K01-65 ; 2010k16-03-01 ; 2010K16-03-02
项目资助者: National Natural Science Foundation of China ; Shaanxi Province Science and Technology Development Projection
WOS记录号: WOS:000328844200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60272
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Fourth Mil Med Univ, Dept Radiol, Tangdu Hosp, Xian 710038, Peoples R China
2.Xi An Jiao Tong Univ, Dept Oncol, Affiliated Hosp 1, Xian 710061, Peoples R China
3.Univ Florida, Coll Med, Dept Psychiat, Gainesville, FL 32610 USA
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
5.Fourth Mil Med Univ, Dept Nephrol, Tangdu Hosp, Xian 710038, Peoples R China

Recommended Citation:
Wang, Yarong,Zhu, Jia,Chen, Ling,et al. THE EFFECT OF NUCLEUS ACCUMBENS LESIONS ON APPETITE, SEXUAL FUNCTION, AND NICOTINE DEPENDENCE IN RECOVERING HEROIN ADDICTS[J]. TRANSLATIONAL NEUROSCIENCE,2013,4(4):419-428.
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