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Ethnic Difference of the Anterior Chamber Area and Volume and Its Association with Angle Width
Wang, Dandan1,2; Qi, Meng3; He, Mingguang1; Wu, Lingling3; Lin, Shan2
刊名INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2012-05-01
DOI10.1167/iovs.12-9776
53期:6页:3139-3144
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
资助者George and Rosalie Hearst Foreign Fellowship ; That Man May See, Inc. ; Research to Prevent Blindness ; National Eye Institute ; George and Rosalie Hearst Foreign Fellowship ; That Man May See, Inc. ; Research to Prevent Blindness ; National Eye Institute
研究领域[WOS]Ophthalmology
关键词[WOS]OPTICAL COHERENCE TOMOGRAPHY ; CLOSURE GLAUCOMA ; SINGAPOREANS ; CHINESE
英文摘要

PURPOSE. To compare the anterior chamber area/volume (ACA/ACV) and their relationship with the drainage angle between adult Caucasians and Chinese.

METHODS. Study groups were comprised of four age- and sex-matched cohorts: American Caucasians, American Chinese, southern mainland Chinese, and northern mainland Chinese. All subjects were consecutively recruited from general ophthalmology clinics except for southern mainland Chinese participants who were drawn from an ongoing population-based study. Anterior segment optical coherence tomography (ASOCT) images were obtained under dark conditions. Customized software was used to analyze structural indices including ACA/ACV, angle opening distance (AOD), anterior chamber depth (ACD), anterior chamber width (ACW), lens vault (LV), corneal arc depth (CAD), iris thickness (IT), iris curvature (ICurv), and iris area (IArea).

RESULTS. Data from 121, 124, 121, and 120 participants were obtained of American Caucasians, American Chinese, and southern and northern mainland Chinese, respectively. After multiple linear regression analysis, adjusting for age, sex, pupil diameter (PD), and axial length (AL), ACA/ACV was positively associated with ACD, ACW, CAD, and corneal radius of curvature (CR) but negatively related with ICurv and IArea. Ethnic Chinese had significantly smaller ACA (beta = -0.18, P = 0.022) and ACV (beta = -3.9, P = 0.001) than Caucasians. ACV contributes the most to AOD variation for both Chinese (standardized regression coefficient [SRC] = 0.47, P < 0.001) and Caucasians (SRC = 0.59, P < 0.001).

CONCLUSIONS. Compared with Caucasians, ethnic Chinese had smaller ACA/ACV independent of ACD, ACW, ICurv, IArea, PD, CR, and AL. ACA/ACV is the most prominent contributor to angle width variation for both Chinese and Caucasians in this study. (Invest Ophthalmol Vis Sci. 2012;53:3139-3144) DOI:10.1167/iovs.12-9776

语种英语
所属项目编号EY002161
资助者George and Rosalie Hearst Foreign Fellowship ; That Man May See, Inc. ; Research to Prevent Blindness ; National Eye Institute ; George and Rosalie Hearst Foreign Fellowship ; That Man May See, Inc. ; Research to Prevent Blindness ; National Eye Institute
WOS记录号WOS:000304864600072
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60275
专题北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Hosp 3, Ctr Eye, Beijing 100871, Peoples R China
2.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510275, Guangdong, Peoples R China
3.Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA USA
推荐引用方式
GB/T 7714
Wang, Dandan,Qi, Meng,He, Mingguang,et al. Ethnic Difference of the Anterior Chamber Area and Volume and Its Association with Angle Width[J]. INVESTIGATIVE OPHTHALMOLOGY &amp; VISUAL SCIENCE,2012,53(6):3139-3144.
APA Wang, Dandan,Qi, Meng,He, Mingguang,Wu, Lingling,&Lin, Shan.(2012).Ethnic Difference of the Anterior Chamber Area and Volume and Its Association with Angle Width.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,53(6),3139-3144.
MLA Wang, Dandan,et al."Ethnic Difference of the Anterior Chamber Area and Volume and Its Association with Angle Width".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53.6(2012):3139-3144.
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