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学科主题: 临床医学
题名:
Ethnic Difference of the Anterior Chamber Area and Volume and Its Association with Angle Width
作者: Wang, Dandan1,2; Qi, Meng3; He, Mingguang1; Wu, Lingling3; Lin, Shan2
刊名: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
发表日期: 2012-05-01
DOI: 10.1167/iovs.12-9776
卷: 53, 期:6, 页:3139-3144
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: OPTICAL COHERENCE TOMOGRAPHY ; CLOSURE GLAUCOMA ; SINGAPOREANS ; CHINESE
英文摘要:

PURPOSE. To compare the anterior chamber area/volume (ACA/ACV) and their relationship with the drainage angle between adult Caucasians and Chinese.

METHODS. Study groups were comprised of four age- and sex-matched cohorts: American Caucasians, American Chinese, southern mainland Chinese, and northern mainland Chinese. All subjects were consecutively recruited from general ophthalmology clinics except for southern mainland Chinese participants who were drawn from an ongoing population-based study. Anterior segment optical coherence tomography (ASOCT) images were obtained under dark conditions. Customized software was used to analyze structural indices including ACA/ACV, angle opening distance (AOD), anterior chamber depth (ACD), anterior chamber width (ACW), lens vault (LV), corneal arc depth (CAD), iris thickness (IT), iris curvature (ICurv), and iris area (IArea).

RESULTS. Data from 121, 124, 121, and 120 participants were obtained of American Caucasians, American Chinese, and southern and northern mainland Chinese, respectively. After multiple linear regression analysis, adjusting for age, sex, pupil diameter (PD), and axial length (AL), ACA/ACV was positively associated with ACD, ACW, CAD, and corneal radius of curvature (CR) but negatively related with ICurv and IArea. Ethnic Chinese had significantly smaller ACA (beta = -0.18, P = 0.022) and ACV (beta = -3.9, P = 0.001) than Caucasians. ACV contributes the most to AOD variation for both Chinese (standardized regression coefficient [SRC] = 0.47, P < 0.001) and Caucasians (SRC = 0.59, P < 0.001).

CONCLUSIONS. Compared with Caucasians, ethnic Chinese had smaller ACA/ACV independent of ACD, ACW, ICurv, IArea, PD, CR, and AL. ACA/ACV is the most prominent contributor to angle width variation for both Chinese and Caucasians in this study. (Invest Ophthalmol Vis Sci. 2012;53:3139-3144) DOI:10.1167/iovs.12-9776

语种: 英语
所属项目编号: EY002161
项目资助者: George and Rosalie Hearst Foreign Fellowship ; That Man May See, Inc. ; Research to Prevent Blindness ; National Eye Institute
WOS记录号: WOS:000304864600072
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60275
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Ctr Eye, Beijing 100871, Peoples R China
2.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510275, Guangdong, Peoples R China
3.Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA USA

Recommended Citation:
Wang, Dandan,Qi, Meng,He, Mingguang,et al. Ethnic Difference of the Anterior Chamber Area and Volume and Its Association with Angle Width[J]. INVESTIGATIVE OPHTHALMOLOGY &amp; VISUAL SCIENCE,2012,53(6):3139-3144.
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