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学科主题: 临床医学
题名:
Acute renal failure in chronic kidney disease - clinical and pathological analysis of 104 cases
作者: Zhang, L; Wang, M; Wang, H
关键词: acute renal failure ; chronic kidney disease ; etiology ; prognosis
刊名: CLINICAL NEPHROLOGY
发表日期: 2005-05-01
卷: 63, 期:5, 页:346-350
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: FINGERNAIL CREATININE ; EPIDEMIOLOGY ; INSUFFICIENCY ; MULTICENTER ; MANAGEMENT ; ICU
英文摘要:

Background: Acute renal failure in chronic kidney disease (A/C) constitutes an important part of acute renal failure (ARF), but until now there has been no research focusing on this entity. Patients and methods: Clinical data were collected from all patients diagnosed as A/C by clinical materials and renal biopsy over a 12-year period (January 1990-December 2001) in the renal department of a teaching hospital, and the incidence, etiology, pathological and clinical features of A/C, and factors predicting prognosis were studied. Results: Altogether, 104 patients of A/C were identified, which accounted for 35.5% of biopsied acute renal failure cases during the same period. Drug-induced acute renal interstitial/tubular-interstitial disease, prerenal ARF and flare-up of lupus nephritis were the most common causes of ARF in A/C patients. More than one third of A/C were associated with drugs, which occurred more commonly in older patients. After an average hospitalization of 28.5 days, about 39 patients required dialysis, 23 patients became dialysis-independent. The mortality was 1.9%. Furthermore, serum creatinine (Scr) returned to normal level (< 133 μ mol/l) in 46.2% of all patients; Scr decreased by 15%, yet not normal in 26.0%. Multivariate logistic regression analysis indicated that hypertension, requirement of dialysis therapy and high Scr level were independent predictors of poor renal outcome. Conclusion: A/C constitutes an important part of ARF, and drug-induced ARF is prominent in China. Because early diagnosis and correct treatment may obviously affect prognosis, enough attention should be paid to this entity.

语种: 英语
WOS记录号: WOS:000228936800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60277
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, First Hosp, Div Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, L,Wang, M,Wang, H. Acute renal failure in chronic kidney disease - clinical and pathological analysis of 104 cases[J]. CLINICAL NEPHROLOGY,2005,63(5):346-350.
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