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Increased Levels of Hypoxia-Inducible Factor-1 alpha Are Associated with Bcl-xL Expression, Tumor Apoptosis, and Clinical Outcome in Chondrosarcoma
Chen, Changbao; Zhou, Hua; Wei, Feng; Jiang, Liang; Liu, Xiaoguang; Liu, Zhongjun; Ma, Qingjun
关键词hypoxia-inducible factor-1 alpha Bcl-xL apoptosis clinical outcome chondrosarcoma
刊名JOURNAL OF ORTHOPAEDIC RESEARCH
2011
DOI10.1002/jor.21193
29期:1页:143-151
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Orthopedics
研究领域[WOS]Orthopedics
关键词[WOS]HIPPEL-LINDAU PROTEIN ; CARTILAGE TUMORS ; GENE-EXPRESSION ; UP-REGULATION ; PERIPHERAL CHONDROSARCOMA ; UNFAVORABLE PROGNOSIS ; FACTOR (HIF)-1-ALPHA ; FACTOR 1-ALPHA ; HUMAN CANCERS ; OVEREXPRESSION
英文摘要

Hypoxia-inducible factor (HIF)-1 alpha is a key nuclear transcription factor that regulates the cellular response to hypoxia, and is important for solid tumor growth and survival. However; the underlying role of HIF-1 alpha in human chondrosarcoma has not been well characterized. This study aims to investigate the expression patterns of HIF-1 alpha in chondrosarcoma, and its association with clinicopathologic features, Bcl-xL expression, apoptosis index (AI), and overall survival of patients with chondrosarcoma. Our results shown that the protein levels of HIF-1 alpha were increased, and the mRNA and protein levels of Bcl-xL were also increased in SW1353 cells under hypoxic conditions. In eight patients with chondrosarcoma, increased expression of HIF-1 alpha and Bcl-xL was detected in chondrosarcoma tissues compared with the paired adjacent normal tissues. Of 34 archival specimens of chondrosarcomas, 20(58.3%) showed high HIF-1 alpha protein expression as compared to benign cartilage tumors. Increased HIF-1 alpha expression was correlated with a higher pathological grade and MSTS stage of chondrosarcoma. Moreover, HIF-1 alpha expression was significantly associated with Bcl-xL expression and AI. More significantly, the survival rate of patients with HIF-1 alpha high tumors was significantly lower than that of patients with HIF-1 alpha low tumors. These findings suggest that increased HIF-1 alpha levels mediated up-regulation of Bcl-xL play a prominent role in evasion of apoptosis and tumor progression, and can be predictive for the prognosis in human chondrosarcoma. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29: 143-151, 2011

语种英语
WOS记录号WOS:000285321900023
项目编号30571870
资助机构National Natural Sciences Foundation of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60279
专题北京大学第三临床医学院_骨科
作者单位Peking Univ, Hosp 3, Dept Orthopaed Surg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Changbao,Zhou, Hua,Wei, Feng,et al. Increased Levels of Hypoxia-Inducible Factor-1 alpha Are Associated with Bcl-xL Expression, Tumor Apoptosis, and Clinical Outcome in Chondrosarcoma[J]. JOURNAL OF ORTHOPAEDIC RESEARCH,2011,29(1):143-151.
APA Chen, Changbao.,Zhou, Hua.,Wei, Feng.,Jiang, Liang.,Liu, Xiaoguang.,...&Ma, Qingjun.(2011).Increased Levels of Hypoxia-Inducible Factor-1 alpha Are Associated with Bcl-xL Expression, Tumor Apoptosis, and Clinical Outcome in Chondrosarcoma.JOURNAL OF ORTHOPAEDIC RESEARCH,29(1),143-151.
MLA Chen, Changbao,et al."Increased Levels of Hypoxia-Inducible Factor-1 alpha Are Associated with Bcl-xL Expression, Tumor Apoptosis, and Clinical Outcome in Chondrosarcoma".JOURNAL OF ORTHOPAEDIC RESEARCH 29.1(2011):143-151.
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