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学科主题: 临床医学
题名:
Increased Levels of Hypoxia-Inducible Factor-1 alpha Are Associated with Bcl-xL Expression, Tumor Apoptosis, and Clinical Outcome in Chondrosarcoma
作者: Chen, Changbao; Zhou, Hua; Wei, Feng; Jiang, Liang; Liu, Xiaoguang; Liu, Zhongjun; Ma, Qingjun
关键词: hypoxia-inducible factor-1 alpha ; Bcl-xL ; apoptosis ; clinical outcome ; chondrosarcoma
刊名: JOURNAL OF ORTHOPAEDIC RESEARCH
发表日期: 2011
DOI: 10.1002/jor.21193
卷: 29, 期:1, 页:143-151
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Orthopedics
研究领域[WOS]: Orthopedics
关键词[WOS]: HIPPEL-LINDAU PROTEIN ; CARTILAGE TUMORS ; GENE-EXPRESSION ; UP-REGULATION ; PERIPHERAL CHONDROSARCOMA ; UNFAVORABLE PROGNOSIS ; FACTOR (HIF)-1-ALPHA ; FACTOR 1-ALPHA ; HUMAN CANCERS ; OVEREXPRESSION
英文摘要:

Hypoxia-inducible factor (HIF)-1 alpha is a key nuclear transcription factor that regulates the cellular response to hypoxia, and is important for solid tumor growth and survival. However; the underlying role of HIF-1 alpha in human chondrosarcoma has not been well characterized. This study aims to investigate the expression patterns of HIF-1 alpha in chondrosarcoma, and its association with clinicopathologic features, Bcl-xL expression, apoptosis index (AI), and overall survival of patients with chondrosarcoma. Our results shown that the protein levels of HIF-1 alpha were increased, and the mRNA and protein levels of Bcl-xL were also increased in SW1353 cells under hypoxic conditions. In eight patients with chondrosarcoma, increased expression of HIF-1 alpha and Bcl-xL was detected in chondrosarcoma tissues compared with the paired adjacent normal tissues. Of 34 archival specimens of chondrosarcomas, 20(58.3%) showed high HIF-1 alpha protein expression as compared to benign cartilage tumors. Increased HIF-1 alpha expression was correlated with a higher pathological grade and MSTS stage of chondrosarcoma. Moreover, HIF-1 alpha expression was significantly associated with Bcl-xL expression and AI. More significantly, the survival rate of patients with HIF-1 alpha high tumors was significantly lower than that of patients with HIF-1 alpha low tumors. These findings suggest that increased HIF-1 alpha levels mediated up-regulation of Bcl-xL play a prominent role in evasion of apoptosis and tumor progression, and can be predictive for the prognosis in human chondrosarcoma. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29: 143-151, 2011

语种: 英语
所属项目编号: 30571870
项目资助者: National Natural Sciences Foundation of China
WOS记录号: WOS:000285321900023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60279
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Orthopaed Surg, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Changbao,Zhou, Hua,Wei, Feng,et al. Increased Levels of Hypoxia-Inducible Factor-1 alpha Are Associated with Bcl-xL Expression, Tumor Apoptosis, and Clinical Outcome in Chondrosarcoma[J]. JOURNAL OF ORTHOPAEDIC RESEARCH,2011,29(1):143-151.
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