IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科
学科主题临床医学
Gamma-Ray Resistance of Regulatory CD4(+)CD25(+)Foxp3(+) T Cells in Mice
Qu, Yanyan1,2; Jin, Shuguang3; Zhang, Aijun1,4; Zhang, Baojun1,2; Shi, Xiaoyun1; Wang, Junjie5; Zhao, Yong1,2
刊名RADIATION RESEARCH
2010-02-01
DOI10.1667/RR0978.1
173期:2页:148-157
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology ; Biophysics ; Radiology, Nuclear Medicine & Medical Imaging
资助者Chinese Academy of Sciences ; National Natural Science Foundation for Distinguished Young Scholars ; Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry ; Chinese Academy of Sciences ; National Natural Science Foundation for Distinguished Young Scholars ; Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry
研究领域[WOS]Life Sciences & Biomedicine - Other Topics ; Biophysics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]IMMUNOLOGICAL SELF-TOLERANCE ; ANTIGEN-PRESENTING CELLS ; PERIPHERAL-BLOOD ; EFFECTOR ; CD4(+) ; FOXP3 ; LYMPHOCYTES ; IRRADIATION ; RADIATION ; APOPTOSIS
英文摘要

CD4(+)CD25(+) regulatory T cells (Treg cells) are an important subset of T cells for keeping proper immune responses and tolerance. However, the effects of gamma radiation on CD4(+)CD25(high) Foxp3(+) Treg cells have not been examined previously. In the present study, we compared the sensitivity of mouse CD4(+)CD25(high) Foxp3(+) Treg cells and CD4(+)CD25(-) T cells to gamma radiation in vitro and in vivo. After C57BL/6 mice received a whole-body dose of 5 Gy gamma rays, the numbers of lymphocyte subsets in blood, lymph nodes, spleens and thymuses clearly decreased. However, gamma radiation significantly enhanced the ratios of CD4(+)CD25(high) Treg cells and CD4(+)CD25(high) Foxp3(+) Treg cells to CD4(+) T cells in the blood, lymph nodes, spleens and thymuses of mice. More dead cells were observed in CD4(+)CD25(-) T cells than in CD4(+)CD25(high) Treg cells or CD4(+)CD25(high) Foxp3(+) Treg cells when the cells were irradiated in vitro, indicating that CD4(+)CD25(high) Foxp3(+) Treg cells are more resistant to gamma radiation than other T cells. Moreover, a higher expression of Bcl-2 in CD4(+)CD25(high) Treg cells was detected compared with that in CD4(+)CD25(-) T cells. CD4(+)CD25(+) Treg cells from irradiated mice were functional, though their immunosuppressive ability was somewhat impaired compared to those from nonirradiated mice as determined by an in vitro assay. These results indicate that mouse CD4(+)CD25(+) Treg cells and CD4(+)CD25(-) T effector cells have different sensitivities to gamma radiation in mice. (C) 2010 by Radiation Research Society

语种英语
所属项目编号KJCX2-YW-L08 ; C03020504 ; 2005-546
资助者Chinese Academy of Sciences ; National Natural Science Foundation for Distinguished Young Scholars ; Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry ; Chinese Academy of Sciences ; National Natural Science Foundation for Distinguished Young Scholars ; Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry
WOS记录号WOS:000274270200003
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60280
Collection北京大学第三临床医学院_肿瘤放疗科
作者单位1.Beihua Univ, Sch Publ Hlth, Beijing, Jilin, Peoples R China
2.Chinese Acad Sci, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Inst Zool, Beijing 100101, Peoples R China
3.Chinese Acad Sci, China US Res Ctr Life Sci, Beijing 100101, Peoples R China
4.Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250100, Peoples R China
5.Peking Univ, Dept Radiat Oncol, Hosp 3, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Qu, Yanyan,Jin, Shuguang,Zhang, Aijun,et al. Gamma-Ray Resistance of Regulatory CD4(+)CD25(+)Foxp3(+) T Cells in Mice[J]. RADIATION RESEARCH,2010,173(2):148-157.
APA Qu, Yanyan.,Jin, Shuguang.,Zhang, Aijun.,Zhang, Baojun.,Shi, Xiaoyun.,...&Zhao, Yong.(2010).Gamma-Ray Resistance of Regulatory CD4(+)CD25(+)Foxp3(+) T Cells in Mice.RADIATION RESEARCH,173(2),148-157.
MLA Qu, Yanyan,et al."Gamma-Ray Resistance of Regulatory CD4(+)CD25(+)Foxp3(+) T Cells in Mice".RADIATION RESEARCH 173.2(2010):148-157.
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