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IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科  > 期刊论文
学科主题: 临床医学
题名:
Gamma-Ray Resistance of Regulatory CD4(+)CD25(+)Foxp3(+) T Cells in Mice
作者: Qu, Yanyan1,2; Jin, Shuguang3; Zhang, Aijun1,4; Zhang, Baojun1,2; Shi, Xiaoyun1; Wang, Junjie5; Zhao, Yong1,2
刊名: RADIATION RESEARCH
发表日期: 2010-02-01
DOI: 10.1667/RR0978.1
卷: 173, 期:2, 页:148-157
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology ; Biophysics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics ; Biophysics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: IMMUNOLOGICAL SELF-TOLERANCE ; ANTIGEN-PRESENTING CELLS ; PERIPHERAL-BLOOD ; EFFECTOR ; CD4(+) ; FOXP3 ; LYMPHOCYTES ; IRRADIATION ; RADIATION ; APOPTOSIS
英文摘要:

CD4(+)CD25(+) regulatory T cells (Treg cells) are an important subset of T cells for keeping proper immune responses and tolerance. However, the effects of gamma radiation on CD4(+)CD25(high) Foxp3(+) Treg cells have not been examined previously. In the present study, we compared the sensitivity of mouse CD4(+)CD25(high) Foxp3(+) Treg cells and CD4(+)CD25(-) T cells to gamma radiation in vitro and in vivo. After C57BL/6 mice received a whole-body dose of 5 Gy gamma rays, the numbers of lymphocyte subsets in blood, lymph nodes, spleens and thymuses clearly decreased. However, gamma radiation significantly enhanced the ratios of CD4(+)CD25(high) Treg cells and CD4(+)CD25(high) Foxp3(+) Treg cells to CD4(+) T cells in the blood, lymph nodes, spleens and thymuses of mice. More dead cells were observed in CD4(+)CD25(-) T cells than in CD4(+)CD25(high) Treg cells or CD4(+)CD25(high) Foxp3(+) Treg cells when the cells were irradiated in vitro, indicating that CD4(+)CD25(high) Foxp3(+) Treg cells are more resistant to gamma radiation than other T cells. Moreover, a higher expression of Bcl-2 in CD4(+)CD25(high) Treg cells was detected compared with that in CD4(+)CD25(-) T cells. CD4(+)CD25(+) Treg cells from irradiated mice were functional, though their immunosuppressive ability was somewhat impaired compared to those from nonirradiated mice as determined by an in vitro assay. These results indicate that mouse CD4(+)CD25(+) Treg cells and CD4(+)CD25(-) T effector cells have different sensitivities to gamma radiation in mice. (C) 2010 by Radiation Research Society

语种: 英语
所属项目编号: KJCX2-YW-L08 ; C03020504 ; 2005-546
项目资助者: Chinese Academy of Sciences ; National Natural Science Foundation for Distinguished Young Scholars ; Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry
WOS记录号: WOS:000274270200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60280
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Beihua Univ, Sch Publ Hlth, Beijing, Jilin, Peoples R China
2.Chinese Acad Sci, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Inst Zool, Beijing 100101, Peoples R China
3.Chinese Acad Sci, China US Res Ctr Life Sci, Beijing 100101, Peoples R China
4.Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250100, Peoples R China
5.Peking Univ, Dept Radiat Oncol, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Qu, Yanyan,Jin, Shuguang,Zhang, Aijun,et al. Gamma-Ray Resistance of Regulatory CD4(+)CD25(+)Foxp3(+) T Cells in Mice[J]. RADIATION RESEARCH,2010,173(2):148-157.
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