北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 牙周科  > 期刊论文
学科主题: 口腔医学
题名:
Salivary biomarkers indicate obstructive sleep apnea patients with cardiovascular diseases
作者: Zheng, Hui1; Li, Ruoxuan2; Zhang, Jieni1; Zhou, Shaonan1; Ma, Qingwei3; Zhou, Yanheng1; Chen, Feng4; Lin, Jiuxiang1
刊名: SCIENTIFIC REPORTS
发表日期: 2014-11-14
DOI: 10.1038/srep07046
卷: 4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: FETUIN-A ; HYPERTENSION ; PROTEOMICS ; DISCOVERY ; TOOL
英文摘要:

Although obstructive sleep apnea (OSA) patients are at high risk of developing cardiovascular disease (CVD), only a small proportion is currently diagnosed. To explore and identify the differentially expressed proteins/peptides of OSA patients with CVDs, a mass spectrometry-based salivary analysis was performed. In our study, eleven peaks were observed differentially expressed in saliva from the non-CVD and CVD groups. Five masses mass peaks (1594.1, 1673.7, 1196.6, 1290.5, and 1447.0 Da) showed an upregulated trend in the CVD group, whereas six mass peaks (3038.6, 2164.3, 2301.4, 3195.0, 2628.4, and 1721.9 Da) were downregulated in the CVD group. In addition, the alpha-2-HS-glycoprotein (AHSG) levels in saliva were verified to be decreased in CVD group compared to non-CVD group. Analysis of the salivary peptidome provides a promising approach to screening for novel biomarkers before further identification, and may contribute to early diagnosis of CVD patients with OSA.

语种: 英语
所属项目编号: 81200762
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000345297800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60282
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Capital Med Univ, Beijing Anzhen Hosp, Dept Stomatol, Beijing 100029, Peoples R China
3.BioyongTech, Beijing 100085, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Zheng, Hui,Li, Ruoxuan,Zhang, Jieni,et al. Salivary biomarkers indicate obstructive sleep apnea patients with cardiovascular diseases[J]. SCIENTIFIC REPORTS,2014,4.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zheng, Hui]'s Articles
[Li, Ruoxuan]'s Articles
[Zhang, Jieni]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zheng, Hui]‘s Articles
[Li, Ruoxuan]‘s Articles
[Zhang, Jieni]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace