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Usefulness of Frequency-Doubling Technology for Perimetrically Normal Eyes of Open-Angle Glaucoma Patients with Unilateral Field Loss
Fan, Xiang; Wu, Ling-Ling; Ma, Zhi-Zhong; Xiao, Ge-Ge; Liu, Feng, Jr.
刊名OPHTHALMOLOGY
2010-08-01
DOI10.1016/j.ophtha.2009.12.034
117期:8页:1530-U93
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]NORMAL-TENSION GLAUCOMA ; OPTIC-NERVE HEAD ; STANDARD AUTOMATED PERIMETRY ; COHERENCE TOMOGRAPHY ; CONTRALATERAL EYE ; VISUAL PROGNOSIS ; STATIC PERIMETRY ; NEURORETINAL RIM ; FIBER LAYER ; PROGRESSION
英文摘要

Purpose: To determine whether frequency-doubling technology (FDT) perimetry detects visual field loss in perimetrically normal eyes of patients with open-angle glaucoma (OAG) and whether these visual field defects subsequently are detected by standard automated perimetry (SAP), and to explore the relating factors of the progression from abnormalities based on FDT to visual field loss based on SAP.

Design: Prospective cohort study.

Participants: Sixty-eight OAG patients with unilateral field loss detected by SAP (Octopus, G2 program; Interzeig, Schlieren, Switzerland).

Methods: Perimetrically normal eyes of participants were examined with the FDT N-30 threshold program (Humphrey Instruments, Welch-Allyn, Skaneateles, NY). The visual field examination was followed by a series of SAP examinations administered over 3 years.

Main Outcome Measures: The relationship between FDT and subsequent SAP results in perimetrically normal eyes was analyzed. Glaucomatous optic neuropathy (GON), visual field indices, intraocular pressure (IOP), and central corneal thickness (CCT) were compared between converters (eyes with subsequent SAP abnormality) and nonconverters within perimetrically normal eyes with abnormal FDT results. Finally, the SAP test points were matched to the abnormal FDT sectors. The relative risk (RR) of subsequent SAP abnormality corresponding to FDT abnormal sectors was calculated.

Results: Sixty perimetrically normal eyes of 60 participants had complete data and a qualifying follow-up. Baseline FDT results were abnormal in 65%. Of the eyes with abnormal FDT results, 51% developed abnormal SAP results after 4 to 27 months, whereas none of the eyes with normal FDT results developed abnormal SAP results (P<0.05). In perimetrically normal eyes with abnormal FDT results, converters had a greater cup-to-disc ratio, more eyes with GON, larger and deeper cups, and worse FDT mean deviation than nonconverters (P<0.05). The IOP and CCT did not differ between the 2 groups. The RR of subsequent SAP abnormality corresponding to abnormal FDT sectors was 5.38 (95% confidence interval, 3.61-8.04; P<0.05).

Conclusions: In perimetrically normal eyes of OAG patients, FDT detected visual field loss in almost 2 of every 3 of these eyes and also predicted to some extent future visual field loss on SAP. Severity of glaucomatous neuropathy at baseline was related to conversion of abnormalities on FDT to visual field loss on SAP.

Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2010; 117: 1530-1537 (C) 2010 by the American Academy of Ophthalmology.

语种英语
WOS记录号WOS:000280598900012
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60285
专题北京大学第三临床医学院_眼科
北京大学基础医学院
作者单位Peking Univ Third Hosp, Peking Univ Eye Ctr, Key Lab Vis Loss & Restorat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Fan, Xiang,Wu, Ling-Ling,Ma, Zhi-Zhong,et al. Usefulness of Frequency-Doubling Technology for Perimetrically Normal Eyes of Open-Angle Glaucoma Patients with Unilateral Field Loss[J]. OPHTHALMOLOGY,2010,117(8):1530-U93.
APA Fan, Xiang,Wu, Ling-Ling,Ma, Zhi-Zhong,Xiao, Ge-Ge,&Liu, Feng, Jr..(2010).Usefulness of Frequency-Doubling Technology for Perimetrically Normal Eyes of Open-Angle Glaucoma Patients with Unilateral Field Loss.OPHTHALMOLOGY,117(8),1530-U93.
MLA Fan, Xiang,et al."Usefulness of Frequency-Doubling Technology for Perimetrically Normal Eyes of Open-Angle Glaucoma Patients with Unilateral Field Loss".OPHTHALMOLOGY 117.8(2010):1530-U93.
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