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学科主题: 口腔医学
题名:
The Pittsburgh Oral-Facial Cleft study: Expanding the cleft phenotype. Background and justification
作者: Weinberg, SM; Neiswanger, K; Martin, RA; Mooney, MP; Kane, AA; Wenger, SL; Losee, J; Deleyiannis, F; Ma, L; De Salamanca, JE; Czeizel, AE; Marazita, ML
关键词: associated anomalies ; cleft lip ; cleft lip and palate ; phenotype ; unaffected relatives
刊名: CLEFT PALATE-CRANIOFACIAL JOURNAL
发表日期: 2006
卷: 43, 期:1, 页:7-20
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]: LIP AND/OR PALATE ; MINOR PHYSICAL ANOMALIES ; 3-DIMENSIONAL COMPUTER RECONSTRUCTION ; FLUCTUATING DERMATOGLYPHIC ASYMMETRY ; CERVICAL-SPINE ANOMALIES ; ORBICULARIS ORIS MUSCLE ; DEVELOPMENTAL STABILITY ; CRANIOFACIAL MORPHOLOGY ; GENETIC PREDISPOSITION ; DENTAL ASYMMETRY
英文摘要:

The Pittsburgh Oral-Facial Cleft study was begun in 1993 with the primary goal of identifying genes involved in nonsyndromic orofacial clefts in a variety of populations worldwide. Based on the results from a number of pilot studies and preliminary genetic analyses, a new research focus was added to the Pittsburgh Oral-Facial Cleft study in 1999: to elucidate the role that associated phenotypic features play in the familial transmission patterns of orofacial clefts in order to expand the definition of the nonsyndromic cleft phenotype. The purpose of this paper is to provide a comprehensive review of phenotypic features associated with nonsyndromic orofacial clefts. These features include fluctuating and directional asymmetry, non-right-handedness, dermatoglyphic patterns, craniofacial morphology, orbicularis oris muscle defects, dental anomalies, structural brain and vertebral anomalies, minor physical anomalies, and velopharyngeal incompetence.

语种: 英语
WOS记录号: WOS:000234788100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60288
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Washington Univ, Sch Med, Dept Anthropol, St Louis, MO USA
2.W Virginia Univ, Sch Med, Dept Pathol, Morgantown, WV USA
3.Fdn Community Control Hereditary Dis, Budapest, Hungary
4.Eotvos Lorand Tudomany Egyetem, Dept Genet, Budapest, Hungary
5.Univ Pittsburgh, Ctr Craniofacial Dental Genet, Sch Dent Med, Pittsburgh, PA 15219 USA
6.Univ Pittsburgh, Dept Oral Med & Pathol, Pittsburgh, PA USA
7.Univ Pittsburgh, Dept Orthodont, Sch Dent Med, Pittsburgh, PA USA
8.Washington Univ, Cleft Palate Craniofacial Deform Inst, Craniofacial Imaging Lab, Div Plast Reconstruct,Sch Med, St Louis, MO USA
9.Univ Pittsburgh, Childrens Hosp Pittsburgh, Cleft Craniofacial Ctr, Pittsburgh, PA USA
10.Peking Univ, Sch Stomatol, Cleft Lip & Palate Ctr, Beijing, Peoples R China
11.Univ Autonoma Madrid, Nino Jesus Univ Hosp, Dept Plast Surg, Madrid, Spain

Recommended Citation:
Weinberg, SM,Neiswanger, K,Martin, RA,et al. The Pittsburgh Oral-Facial Cleft study: Expanding the cleft phenotype. Background and justification[J]. CLEFT PALATE-CRANIOFACIAL JOURNAL,2006,43(1):7-20.
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