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学科主题: 临床医学
题名:
Lentivector expressing HBsAg and immunoglobulin Fc fusion antigen induces potent immune responses and results in seroconversion in HBsAg transgenic mice
作者: Hong, Yuan1,2; Peng, Yibing2; Mi, Michael5; Xiao, Haiyan2; Munn, David H.2,4; Wang, Gui-qiang1; He, Yukai2,3
关键词: Lentivector ; Hepatitis B virus ; Vaccines ; Genetic immunization ; Immunotherapy ; Chronic HBV infection
刊名: VACCINE
发表日期: 2011-05-17
DOI: 10.1016/j.vaccine.2011.03.025
卷: 29, 期:22, 页:3909-3916
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Medicine, Research & Experimental
研究领域[WOS]: Immunology ; Research & Experimental Medicine
关键词[WOS]: T-CELL RESPONSES ; CHRONIC HEPATITIS-B ; DENDRITIC CELLS ; ANTITUMOR IMMUNITY ; IN-VIVO ; RECOMBINANT LENTIVECTOR ; THERAPEUTIC VACCINATION ; GENETIC IMMUNIZATION ; INFECTION ; LYMPHOCYTES
英文摘要:

Even though hepatitis B virus(HBV) vaccines effectively prevent new cases of HBV infection, with approximately 350 million patients worldwide, chronic HBV infection remains a major health problem because of the associated complications (such as liver cirrhosis and hepatocellular carcinoma) and the limited treatment options. Immunotherapy has the potential to effectively control HBV replication. In this current study, we found that recombinant lentivectors could induce potent HBV surface antigen (HBsAg) specific T cell responses and humoral immune responses. Tagging the HBsAg with immunoglobulin Fc fragment further substantially increased the HBsAg specific immune responses. Remarkably, the HBS-Fc-lv lentivector could effectively break immune tolerance and induce potent HBsAg specific adaptive immune responses in HBsAg transgenic (Tg) mice with low serum level of HBsAg. More importantly, the induction of HBsAg specific immune responses in Tg mice accompanied seroconversion from HBsAg to anti-HBsAg antibody (anti-HBsAb). Our study demonstrated the potential of utilizing lentivector to treat chronic HBV infection following reduction of viral load with antiviral drug therapy. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: R01 CA116444
项目资助者: NIH ; Georgia Research Alliance (GRA) ; Ministry of Science and Technology, China
WOS记录号: WOS:000291370900017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60301
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Georgia Hlth Sci Univ, MCG Canc Ctr, Immunol Immunotherapy Program, Augusta, GA USA
3.Georgia Hlth Sci Univ, Dept Med, Augusta, GA USA
4.Georgia Hlth Sci Univ, Dept Pediat, Augusta, GA USA
5.Harvard Univ, Harvard Coll, Boston, MA 02115 USA

Recommended Citation:
Hong, Yuan,Peng, Yibing,Mi, Michael,et al. Lentivector expressing HBsAg and immunoglobulin Fc fusion antigen induces potent immune responses and results in seroconversion in HBsAg transgenic mice[J]. VACCINE,2011,29(22):3909-3916.
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