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学科主题临床医学
A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain
Han, Hongbin1,2; Shi, Chunyan1,2; Fu, Yu3; Zuo, Long1,2; Lee, Kejia4; He, Qingyuan1,2; Han, Haojun5,6
关键词Brain interstitial fluid extracellular space (ECS) gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) magnetic resonance imaging (MRI) water diffusion
刊名IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
2014-05-01
DOI10.1109/JBHI.2014.2308279
18期:3页:978-983
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Computer Science, Information Systems ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Medical Informatics
研究领域[WOS]Computer Science ; Mathematical & Computational Biology ; Medical Informatics
关键词[WOS]MAGNETIC-RESONANCE ; IN-VIVO ; DELIVERY ; VOLUME ; SLICES
英文摘要

We proposed a novel MRI tracer-based method for the determination of water diffusion in the brain extracellular space (ECS). The measuring system was validated in 32 Sprague Dawley rats. The rats were randomly divided into four groups with different injection sites: 1) caudate nucleus (Cn.); 2) thalamus (T.); 3) cortex (Cor.); and 4) substantia nigra (Sn.). The spin-lattice relaxation time of hydrogen nuclei in water molecules were shortened, which presented as high signal on MRI after the injection of gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) into the rat brain ECS. The enhancement on MRI decreased over time due to the water diffusion and clearance process within the brain ECS. The process was dynamically recorded on a series of magnetic resonance (MR) images. As the increment in signal intensity (Delta SI) could be converted to local Gd-DTPA concentration, the water diffusion parameters were further calculated voxel by voxel based on a modified diffusion model. The most tortuous ECS (lambda = 1.77 +/- 0.71) was found in Sn. with D-*Sn of (2.06 +/- 1.01) x 10(-4)mm(2).s(-1) (P < 0.05). No statistical difference was demonstrated among D-*Cn, D-*T., and D-*Cor. with an average D-* values of (3.28 +/- 0.88) x 10(-4)mm(2).s(-1) (F = 0.18, P > 0.05). By using the tracer-based MRI method, the local diffusion parameters of the brain ECS can be quantitatively measured. The different distribution territories and clearance rates of the tracer in four brain areas indicated that the brain ECS is a physiologically partitioned system.

语种英语
WOS记录号WOS:000336050400029
项目编号81171080 ; 2011YQ030114-10 ; 2012BAI15B009
资助机构National Natural Science Foundation of China ; National Key Scientific Apparatus Development of Special Item ; Twelfth Five-year Plan for the National Science and Technology of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60307
专题北京大学第三临床医学院_神经内科
北京大学第一临床医学院_妇产科
北京大学第三临床医学院_放射科
作者单位1.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Beijing MRI Technol Res Lab, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China
4.Peking Univ, Kavli Inst Astron & Astrophys, Beijing 100871, Peoples R China
5.Peking Univ, Coll Engn, Dept BME, Beijing 100191, Peoples R China
6.Peking Univ, Coll Engn, Beijing MRI Technol Res Lab, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Han, Hongbin,Shi, Chunyan,Fu, Yu,et al. A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain[J]. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS,2014,18(3):978-983.
APA Han, Hongbin.,Shi, Chunyan.,Fu, Yu.,Zuo, Long.,Lee, Kejia.,...&Han, Haojun.(2014).A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain.IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS,18(3),978-983.
MLA Han, Hongbin,et al."A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain".IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS 18.3(2014):978-983.
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