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学科主题: 临床医学
题名:
Significance of eosinophil accumulation in the thrombus and decrease in peripheral blood in patients with acute coronary syndrome
作者: Jiang, Ping1,2; Wang, De-zhao3; Ren, Ya-li4; Cai, Jian-ping1,2; Chen, Bu-xing3
关键词: acute coronary syndrome ; eosinophils ; platelets ; thrombosis
刊名: CORONARY ARTERY DISEASE
发表日期: 2015-03-01
DOI: 10.1097/MCA.0000000000000186
卷: 26, 期:2, 页:101-106
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ACUTE MYOCARDIAL-INFARCTION ; HYPEREOSINOPHILIC SYNDROME ; ANTIPLATELET THERAPY ; PARASITIC DISEASES ; PLATELET COUNT ; ARTERY
英文摘要:

Background and aims It is well known that the interaction between platelets (PLTs), endothelial cells, and leukocytes contributes to thrombosis in patients with acute coronary syndrome. The aim of this study was to investigate the significance of PLTs and eosinophils (EOS) in coronary arterial thrombi.

Methods PLT count, mean PLT volume, PLT mass, EOS count, EOS percentage, and troponin I level in peripheral blood were determined in 81 patients with angina pectoris (AP) and 49 patients with acute myocardial infarction (AMI). A total of 12 thrombus specimens from AMI patients were submitted for histopathological analysis. EOS presence in thrombectomy specimens were checked by hematoxylin-eosin staining and confirmed by Luna staining.

Results Results showed that EOS were present in all 12 samples (100%). Cell count and percentage of EOS in peripheral blood of patients with AMI were lower than those in patients with AP (both P<0.00001). A higher PLT count was observed in AMI patients (243 +/- 70), especially among female patients or those who were older than 60 years, when compared with AP patients (216 +/- 60; all P<0.05). According to the troponin I level, we divided AMI patients into groups I (>= 20 ng/ml) and II (<20 ng/ml). Group I had a lower EOS percentage compared with group II (P=0.0496). PLT count was also lower in group I with no statistical difference found (P=0.1202). Moreover, there was an inverse correlation between the EOS percentage and the troponin I level (r=-0.434).

Conclusion In conclusion, patients with AMI presented with a decreased EOS percentage and an increased PLT count. The decreased EOS percentage suggested serious myocardial damage. The study indicated that EOS play an important role in thrombosis in patients with acute coronary syndrome. Coron Artery Dis 26: 101-106 Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000349452300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60309
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Hosp, Key Lab Geriatr, Beijing 100050, Peoples R China
2.Capital Med Univ, Beijing Inst Geriatr, Minist Hlth, Beijing 100050, Peoples R China
3.Capital Med Univ, Beijing Tiantan Hosp, Dept Cardiol, Beijing 100050, Peoples R China
4.Peking Univ, Hosp 1, Lab Electron Microscopy, Beijing 100871, Peoples R China

Recommended Citation:
Jiang, Ping,Wang, De-zhao,Ren, Ya-li,et al. Significance of eosinophil accumulation in the thrombus and decrease in peripheral blood in patients with acute coronary syndrome[J]. CORONARY ARTERY DISEASE,2015,26(2):101-106.
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