IR@PKUHSC  > 北京大学第三临床医学院  > 神经外科
学科主题临床医学
Intraoperative hemodynamic parameters of middle cerebral artery and other artery aneurysms utilizing transcranial Doppler ultrasonography
Sun, Jianjun1,2; Wang, Shuo1; Zhao, Yuanli1; Zhang, Dong1; Kato, Yoko3; Liu, Isabelle4; Zhao, Jizong1
关键词aneurysms middle cerebral artery intraoperative hemodynamics impingement force rupture brain injury neural regeneration
刊名NEURAL REGENERATION RESEARCH
2010-06-01
DOI10.3969/j.issn.1673-5374.2010.11.012
5期:11页:874-880
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]COMPUTATIONAL FLUID-DYNAMICS ; INTRACRANIAL ANEURYSMS ; INTRAANEURYSMAL FLOW ; MAGNETIC-RESONANCE ; PHASE-CONTRAST ; BIFURCATION ; ANGIOGRAPHY ; GROWTH ; REGION ; STENTS
英文摘要

BACKGROUND: Hemodynamic changes accompany the initiation, development and rupture of middle cerebral artery (MCA) aneurysms. The complexity of the intraaneurysmal hemodynamic factors has not been completely clarified by the indirect measures and methods used in previous studies.

OBJECTIVE: To evaluate correlations of intraoperative hemodynamic factors to initiation and rupture of MCA aneurysms.

DESIGN, TIME AND SETTING: A case-control study was performed at the Department of Neurosurgery, Tiantan Hospital Affiliated to Capital Medical University, China between March and October 2008.

PARTICIPANTS: A total of 12 consecutive patients diagnosed with MCA aneurysms (MCA aneurysms group) and five patients without middle cerebral artery aneurysms (with aneurysms located at other arteries, control group) were enrolled at the Department of Neurosurgery, Tiantan Hospital Affiliated to Capital Medical University, China.

METHODS: The proximal and distal arteries of MCA aneurysms were exposed visibly in the MCA aneurysm group. The M1 segment of MCA without the aneurysm and the aneurysm on other arteries were also exposed visibly in the control group. Hemodynamic indices were then measured using an intraoperative 16 MHz probe installed in a Multi-Dop TCD8X4 device.

MAIN OUTCOME MEASURES: Mean (time-averaged velocity) difference, maximum mean, pulsatility index difference, maximum pulsatility index, resistance index difference, maximum resistance index; correlation of development and rupture of MCA aneurysms to intraoperative hemodynamic factors of the parent artery.

RESULTS: A total of 12 patients underwent microsurgery for treatment to occlude 15 MCA aneurysms. Of the 15 MCA aneurysms, 12 were located at the bifurcation, two at the M1 segment, and one at the M3 segment; eight of the aneurysms were unruptured and seven were ruptured. The whole indices with combination mean difference, maximum mean, and maximum pulsatility index of the aneurysms were important factors influencing the rupture of MCA aneurysms (t = 2.92, P = 0.03, constant). A higher velocity intraaneurismal flow at the bifurcation was identified (t = 3.48, P = 0.01, constant). After the aneurysm was completely occluded, global high-velocity flow could not be detected in the parent arteries (t = 2.57, P = 0.03, constant).

CONCLUSION: When short-term high-velocity blood flow is present, aneurysms can be easily initiated and ruptured at the bifurcation of MCA.

语种英语
WOS记录号WOS:000279895500012
资助机构National Science &amp ; Technique Supporting Program in the 11&lt ; SUP&gt ; th&lt ; /SUP&gt ; Five-Year Plan of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60310
专题北京大学第三临床医学院_神经外科
作者单位1.Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
2.Peking Univ, Hosp 3, Dept Neurosurg, Beijing 100191, Peoples R China
3.Fujita Hlth Univ, Dept Neurosurg, Toyoake Aichil 4701192, Japan
4.Washington Univ, Sch Med, St Louis, MO 63110 USA
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GB/T 7714
Sun, Jianjun,Wang, Shuo,Zhao, Yuanli,et al. Intraoperative hemodynamic parameters of middle cerebral artery and other artery aneurysms utilizing transcranial Doppler ultrasonography[J]. NEURAL REGENERATION RESEARCH,2010,5(11):874-880.
APA Sun, Jianjun.,Wang, Shuo.,Zhao, Yuanli.,Zhang, Dong.,Kato, Yoko.,...&Zhao, Jizong.(2010).Intraoperative hemodynamic parameters of middle cerebral artery and other artery aneurysms utilizing transcranial Doppler ultrasonography.NEURAL REGENERATION RESEARCH,5(11),874-880.
MLA Sun, Jianjun,et al."Intraoperative hemodynamic parameters of middle cerebral artery and other artery aneurysms utilizing transcranial Doppler ultrasonography".NEURAL REGENERATION RESEARCH 5.11(2010):874-880.
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