IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion-weighted MRI
Wang, Jing2; Zhang, Yudong1; Yang, Xuedong1; Wang, Xiaoying1,2; Zhang, Jue2,3; Fang, Jing2,3; Jiang, Xuexiang1
关键词MRI kidney diffusion-weighted imaging contrast-induced nephropathy
刊名JOURNAL OF MAGNETIC RESONANCE IMAGING
2012-05-01
DOI10.1002/jmri.23511
35期:5页:1139-1144
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]ACQUIRED RENAL-INSUFFICIENCY ; INDUCED NEPHROPATHY ; BLOOD-FLOW ; RISK-FACTORS ; RAT-KIDNEY ; DOG KIDNEY ; COEFFICIENT ; VASOCONSTRICTION ; DEFINITION ; SYSTEM
英文摘要

Purpose: To assess the effects of intravenous-injected iodinated contrast medium (CM) on intrarenal water diffusion using noninvasive diffusion-weighted MRI (DW-MRI). Materials and Methods: Ten New Zealand White rabbits were randomized to receive a 6 mL/ kg body weight intravenous injection of clinically used iopamidol-370 (n 7) or an equivalent amount of 0.9% physiological saline (n 3). A sequential DW-MRI was performed to estimate the intrarenal apparent diffusion coefficient (ADC) at 24 h before and 1 h, 24 h, 48 h, and 72 h after administration. Results: Iopamidol produced a progressive ADC reduction in inner stripes of the renal outer medulla (IS) by 13.92% (P 0.05) at 1 h, 17.52% (P 0.02) at 24 h, 20.23% (P 0.01) at 48 h and 16.31% (P 0.04) at 72 h after injection. Cortical ADC was decreased by 14.14% (P 0.01) at 48 h and 14.12% (P 0.01) at 72 h after injection. Iopamidol produced slight decrease of ADCs in outer stripes of the outer medulla (OS) and inner medulla (IM) of kidney but without statistical difference. In control group, no significant ADC changes was observed in each anatomic compartment due to saline injection (P > 0.05). Conclusion: As demonstrated by DW-MRI, intravenous iopamidol injection resulted in a successive reduction of intrarenal water diffusion, particularly in IS of kidney. This MR technique may be used as a noninvasive tool to perform a time course study of the pathogenesis associated with contrast-induced nephropathy (CIN).

语种英语
WOS记录号WOS:000302721800018
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60317
专题北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_医学影像科
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jing,Zhang, Yudong,Yang, Xuedong,et al. Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion-weighted MRI[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2012,35(5):1139-1144.
APA Wang, Jing.,Zhang, Yudong.,Yang, Xuedong.,Wang, Xiaoying.,Zhang, Jue.,...&Jiang, Xuexiang.(2012).Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion-weighted MRI.JOURNAL OF MAGNETIC RESONANCE IMAGING,35(5),1139-1144.
MLA Wang, Jing,et al."Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion-weighted MRI".JOURNAL OF MAGNETIC RESONANCE IMAGING 35.5(2012):1139-1144.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Jing]的文章
[Zhang, Yudong]的文章
[Yang, Xuedong]的文章
百度学术
百度学术中相似的文章
[Wang, Jing]的文章
[Zhang, Yudong]的文章
[Yang, Xuedong]的文章
必应学术
必应学术中相似的文章
[Wang, Jing]的文章
[Zhang, Yudong]的文章
[Yang, Xuedong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。