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学科主题: 临床医学
题名:
Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion-weighted MRI
作者: Wang, Jing2; Zhang, Yudong1; Yang, Xuedong1; Wang, Xiaoying1,2; Zhang, Jue2,3; Fang, Jing2,3; Jiang, Xuexiang1
关键词: MRI ; kidney ; diffusion-weighted imaging ; contrast-induced nephropathy
刊名: JOURNAL OF MAGNETIC RESONANCE IMAGING
发表日期: 2012-05-01
DOI: 10.1002/jmri.23511
卷: 35, 期:5, 页:1139-1144
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: ACQUIRED RENAL-INSUFFICIENCY ; INDUCED NEPHROPATHY ; BLOOD-FLOW ; RISK-FACTORS ; RAT-KIDNEY ; DOG KIDNEY ; COEFFICIENT ; VASOCONSTRICTION ; DEFINITION ; SYSTEM
英文摘要:

Purpose: To assess the effects of intravenous-injected iodinated contrast medium (CM) on intrarenal water diffusion using noninvasive diffusion-weighted MRI (DW-MRI). Materials and Methods: Ten New Zealand White rabbits were randomized to receive a 6 mL/ kg body weight intravenous injection of clinically used iopamidol-370 (n 7) or an equivalent amount of 0.9% physiological saline (n 3). A sequential DW-MRI was performed to estimate the intrarenal apparent diffusion coefficient (ADC) at 24 h before and 1 h, 24 h, 48 h, and 72 h after administration. Results: Iopamidol produced a progressive ADC reduction in inner stripes of the renal outer medulla (IS) by 13.92% (P 0.05) at 1 h, 17.52% (P 0.02) at 24 h, 20.23% (P 0.01) at 48 h and 16.31% (P 0.04) at 72 h after injection. Cortical ADC was decreased by 14.14% (P 0.01) at 48 h and 14.12% (P 0.01) at 72 h after injection. Iopamidol produced slight decrease of ADCs in outer stripes of the outer medulla (OS) and inner medulla (IM) of kidney but without statistical difference. In control group, no significant ADC changes was observed in each anatomic compartment due to saline injection (P > 0.05). Conclusion: As demonstrated by DW-MRI, intravenous iopamidol injection resulted in a successive reduction of intrarenal water diffusion, particularly in IS of kidney. This MR technique may be used as a noninvasive tool to perform a time course study of the pathogenesis associated with contrast-induced nephropathy (CIN).

语种: 英语
WOS记录号: WOS:000302721800018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60317
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Jing,Zhang, Yudong,Yang, Xuedong,et al. Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion-weighted MRI[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2012,35(5):1139-1144.
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