|High-sensitivity CRP: Possible link between job stress and atherosclerosis|
|Xu, Weixian1,2; Chen, Baoxia1,2; Guo, Lijun1,2; Li, Zhaoping1,2; Zhao, Yiming3; Zeng, Hui1,2|
|关键词||job stress effort-reward imbalance inflammation C-reactive protein atherosclerosis|
|刊名||AMERICAN JOURNAL OF INDUSTRIAL MEDICINE|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||C-REACTIVE PROTEIN ; EFFORT-REWARD IMBALANCE ; CORONARY-HEART-DISEASE ; CHRONIC PSYCHOSOCIAL STRESS ; CHINESE WORKERS FINDINGS ; CARDIOVASCULAR-DISEASE ; INFLAMMATORY MARKERS ; WHITEHALL-II ; STRAIN ; ASSOCIATION|
BackgroundChronic inflammation may play an important role in linking job stress to atherosclerosis. We sought to investigate the relationship between job stress and high-sensitivity C-reactive protein (hs-CRP) among Chinese workers.
MethodsA total of 731 subjects (506 men and 225 women) were analyzed. Job stress was evaluated by effort-reward imbalance (ERI) model.
ResultsAmong men, after adjustment for confounders, effort, overcommitment, and ERI were significantly positively correlated with hs-CRP; and reward was significantly inversely related with hs-CRP; high level of effort, overcommitment, or ERI, respectively, significantly increased the odds of high hs-CRP with ORs of 2.0, 3.5, and 3.3 (all P<0.001), compared with the corresponding low level groups. Among women, high overcommitment or ERI also increased risk of high hs-CRP with ORs of 2.8, and 4.1 (P<0.05).
ConclusionsHigh effort, overcommmitment, and ERI were positively associated with hs-CRP. Inflammation indicated by hs-CRP may be one of important mediators linking job stress and atherosclerosis. Am. J. Ind. Med. 58:773-779, 2015. (c) 2015 Wiley Periodicals, Inc.
|项目编号||Y78504-1 ; NNSFC 81400319|
|资助机构||Scientific Research Foundation for the Returned Overseas Scholars of Peking University Third Hospital ; National Natural Science Foundation of China|
|作者单位||1.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100191, Peoples R China|
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
3.Peking Univ, Res Ctr Occupat Med, Hosp 3, Beijing 100191, Peoples R China
|Xu, Weixian,Chen, Baoxia,Guo, Lijun,et al. High-sensitivity CRP: Possible link between job stress and atherosclerosis[J]. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE,2015,58(7):773-779.|
|APA||Xu, Weixian,Chen, Baoxia,Guo, Lijun,Li, Zhaoping,Zhao, Yiming,&Zeng, Hui.(2015).High-sensitivity CRP: Possible link between job stress and atherosclerosis.AMERICAN JOURNAL OF INDUSTRIAL MEDICINE,58(7),773-779.|
|MLA||Xu, Weixian,et al."High-sensitivity CRP: Possible link between job stress and atherosclerosis".AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 58.7(2015):773-779.|