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学科主题临床医学
High-sensitivity CRP: Possible link between job stress and atherosclerosis
Xu, Weixian1,2; Chen, Baoxia1,2; Guo, Lijun1,2; Li, Zhaoping1,2; Zhao, Yiming3; Zeng, Hui1,2
关键词job stress effort-reward imbalance inflammation C-reactive protein atherosclerosis
刊名AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
2015-07-01
DOI10.1002/ajim.22470
58期:7页:773-779
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
资助者Scientific Research Foundation for the Returned Overseas Scholars of Peking University Third Hospital ; National Natural Science Foundation of China ; Scientific Research Foundation for the Returned Overseas Scholars of Peking University Third Hospital ; National Natural Science Foundation of China
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]C-REACTIVE PROTEIN ; EFFORT-REWARD IMBALANCE ; CORONARY-HEART-DISEASE ; CHRONIC PSYCHOSOCIAL STRESS ; CHINESE WORKERS FINDINGS ; CARDIOVASCULAR-DISEASE ; INFLAMMATORY MARKERS ; WHITEHALL-II ; STRAIN ; ASSOCIATION
英文摘要

BackgroundChronic inflammation may play an important role in linking job stress to atherosclerosis. We sought to investigate the relationship between job stress and high-sensitivity C-reactive protein (hs-CRP) among Chinese workers.

MethodsA total of 731 subjects (506 men and 225 women) were analyzed. Job stress was evaluated by effort-reward imbalance (ERI) model.

ResultsAmong men, after adjustment for confounders, effort, overcommitment, and ERI were significantly positively correlated with hs-CRP; and reward was significantly inversely related with hs-CRP; high level of effort, overcommitment, or ERI, respectively, significantly increased the odds of high hs-CRP with ORs of 2.0, 3.5, and 3.3 (all P<0.001), compared with the corresponding low level groups. Among women, high overcommitment or ERI also increased risk of high hs-CRP with ORs of 2.8, and 4.1 (P<0.05).

ConclusionsHigh effort, overcommmitment, and ERI were positively associated with hs-CRP. Inflammation indicated by hs-CRP may be one of important mediators linking job stress and atherosclerosis. Am. J. Ind. Med. 58:773-779, 2015. (c) 2015 Wiley Periodicals, Inc.

语种英语
所属项目编号Y78504-1 ; NNSFC 81400319
资助者Scientific Research Foundation for the Returned Overseas Scholars of Peking University Third Hospital ; National Natural Science Foundation of China ; Scientific Research Foundation for the Returned Overseas Scholars of Peking University Third Hospital ; National Natural Science Foundation of China
WOS记录号WOS:000355979300008
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60319
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
3.Peking Univ, Res Ctr Occupat Med, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xu, Weixian,Chen, Baoxia,Guo, Lijun,et al. High-sensitivity CRP: Possible link between job stress and atherosclerosis[J]. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE,2015,58(7):773-779.
APA Xu, Weixian,Chen, Baoxia,Guo, Lijun,Li, Zhaoping,Zhao, Yiming,&Zeng, Hui.(2015).High-sensitivity CRP: Possible link between job stress and atherosclerosis.AMERICAN JOURNAL OF INDUSTRIAL MEDICINE,58(7),773-779.
MLA Xu, Weixian,et al."High-sensitivity CRP: Possible link between job stress and atherosclerosis".AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 58.7(2015):773-779.
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