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学科主题基础医学
Elevated Levels of Serum IgA against Saccharomyces cerevisiae Mannan in Patients with Rheumatoid Arthritis
Dai, Hui1,3; Li, Zhanguo2; Zhang, Yan1; Lv, Ping1; Gao, Xiao-Ming1,3
关键词autoantibody alpha-1,3-mannan autoimmune diseases RA
刊名CELLULAR & MOLECULAR IMMUNOLOGY
2009-10-01
6期:5页:361-366
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]INFLAMMATORY-BOWEL-DISEASE ; CELIAC-DISEASE ; CROHNS-DISEASE ; ANKYLOSING-SPONDYLITIS ; ANTIBODIES ; CLASSIFICATION ; PREVALENCE ; CRITERIA ; MARKERS ; ASCA
英文摘要

This study was undertaken to investigate whether levels of anti-Saccharomyces cerevisiae mannan antibodies (ASCMA) in human sera, a marker for several autoimmune diseases, correlate with rheumatoid arthritis (RA). ASCMA-IgA, -IgG and -IgM levels were measured with enzyme linked immunosorbent assays (ELISA) in patients with RA (n = 30) and 152 healthy adult controls. ASCMA-IgA prevalence was significantly higher in RA patients (40%) than in healthy subjects (5.3%). A strong correlation between levels of ASCMA-IgA and CRP (r = 0.695; p < 0.01) and ESR (r = 0.708; p < 0.01) in RA patients was observed. No significant differences in ASCMA-IgG or IgM levels were noted between RA patients and healthy control subjects in the present study. This result differs from previous reports. It remains to be evaluated whether elevated ASCMA-levels are common to all rheumatic disorders. Cellular & Molecular Immunology. 2009;6(5):361-366.

语种英语
WOS记录号WOS:000274324100006
项目编号2007CB512406 ; 2006AA02Z495 ; 30371303
资助机构National Key Basic Research Programs ; "863" Program ; Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60325
专题北京大学基础医学院_免疫学系
北京大学第二临床医学院_风湿免疫科
作者单位1.Minist Publ Hlth, Key Lab Immunol, Beijing, Peoples R China
2.Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Dept Rheumatol, Peoples Hosp, Beijing 100083, Peoples R China
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GB/T 7714
Dai, Hui,Li, Zhanguo,Zhang, Yan,et al. Elevated Levels of Serum IgA against Saccharomyces cerevisiae Mannan in Patients with Rheumatoid Arthritis[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2009,6(5):361-366.
APA Dai, Hui,Li, Zhanguo,Zhang, Yan,Lv, Ping,&Gao, Xiao-Ming.(2009).Elevated Levels of Serum IgA against Saccharomyces cerevisiae Mannan in Patients with Rheumatoid Arthritis.CELLULAR & MOLECULAR IMMUNOLOGY,6(5),361-366.
MLA Dai, Hui,et al."Elevated Levels of Serum IgA against Saccharomyces cerevisiae Mannan in Patients with Rheumatoid Arthritis".CELLULAR & MOLECULAR IMMUNOLOGY 6.5(2009):361-366.
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