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学科主题: 基础医学
题名:
Elevated Levels of Serum IgA against Saccharomyces cerevisiae Mannan in Patients with Rheumatoid Arthritis
作者: Dai, Hui1,3; Li, Zhanguo2; Zhang, Yan1; Lv, Ping1; Gao, Xiao-Ming1,3
关键词: autoantibody ; alpha-1,3-mannan ; autoimmune diseases ; RA
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2009-10-01
卷: 6, 期:5, 页:361-366
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: INFLAMMATORY-BOWEL-DISEASE ; CELIAC-DISEASE ; CROHNS-DISEASE ; ANKYLOSING-SPONDYLITIS ; ANTIBODIES ; CLASSIFICATION ; PREVALENCE ; CRITERIA ; MARKERS ; ASCA
英文摘要:

This study was undertaken to investigate whether levels of anti-Saccharomyces cerevisiae mannan antibodies (ASCMA) in human sera, a marker for several autoimmune diseases, correlate with rheumatoid arthritis (RA). ASCMA-IgA, -IgG and -IgM levels were measured with enzyme linked immunosorbent assays (ELISA) in patients with RA (n = 30) and 152 healthy adult controls. ASCMA-IgA prevalence was significantly higher in RA patients (40%) than in healthy subjects (5.3%). A strong correlation between levels of ASCMA-IgA and CRP (r = 0.695; p < 0.01) and ESR (r = 0.708; p < 0.01) in RA patients was observed. No significant differences in ASCMA-IgG or IgM levels were noted between RA patients and healthy control subjects in the present study. This result differs from previous reports. It remains to be evaluated whether elevated ASCMA-levels are common to all rheumatic disorders. Cellular & Molecular Immunology. 2009;6(5):361-366.

语种: 英语
所属项目编号: 2007CB512406 ; 2006AA02Z495 ; 30371303
项目资助者: National Key Basic Research Programs ; "863" Program ; Natural Science Foundation of China
WOS记录号: WOS:000274324100006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60325
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Minist Publ Hlth, Key Lab Immunol, Beijing, Peoples R China
2.Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Dept Rheumatol, Peoples Hosp, Beijing 100083, Peoples R China

Recommended Citation:
Dai, Hui,Li, Zhanguo,Zhang, Yan,et al. Elevated Levels of Serum IgA against Saccharomyces cerevisiae Mannan in Patients with Rheumatoid Arthritis[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2009,6(5):361-366.
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