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Posttreatment with Ma-Xing-Shi-Gan-Tang, a Chinese Medicine Formula, Ameliorates Lipopolysaccharide-Induced Lung Microvessel Hyperpermeability and Inflammatory Reaction in Rat
Ma, Li-Qian1,2,3,4; Pan, Chun-Shui2,3,4; Yang, Ning2,3,4; Liu, Yu-Ying2,3,4; Yan, Li2,3,4; Sun, Kai2,3,4; Wei, Xiao-Hong2,3,4; He, Ke1,2,3,4; Xiao, Meng-Meng1,2,3,4; Fan, Jing-Yu2,3,4; Han, Jing-Yan1,2,3,4
关键词leukocyte hyperpermeability caveolin-1 Src tight junction
刊名MICROCIRCULATION
2014-10-01
DOI10.1111/micc.12144
21期:7页:649-663
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
资助者Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China ; Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]NITRIC-OXIDE SYNTHASE ; MICROCIRCULATORY DISTURBANCE ; MAXINGSHIGAN-YINQIAOSAN ; GLYCYRRHIZA-INFLATA ; OXIDATIVE STRESS ; TIGHT JUNCTIONS ; GROWTH-FACTOR ; IN-VIVO ; INJURY ; LICOCHALCONE
英文摘要

ObjectiveThe aim of present study was to investigate the efficacy of MXSGT, a traditional Chinese medicine formula used for treatment of respiratory system diseases, in the LPS-induced rat ALI particularly with a focus on its effect on lung microvascular hyperpermeability and inflammatory reaction.

MethodsMale Sprague-Dawley rats were injected with LPS (7.5mg/kg, 1.5mg/mL) intraperitoneally. MXSGT (0.52g or 2.61g/kg) was given by gavage six hours after LPS injection.

ResultsLPS stimulation resulted in a reduced survival rate, deteriorated vital signs, an increase in the number of leukocytes adhering to lung venules, the albumin leakage, the activity of MPO in lung tissues, the production of pro-inflammatory cytokines and lung perivascular edema. After LPS stimulation, western blot analysis revealed an increase in the expression of ICAM-1 and toll-like receptor 4, a decrease in tight junction proteins and an activation of cav-1, Src, and NF-B. All the LPS-induced alterations were significantly attenuated by posttreatment with MXSGT.

ConclusionsThis study demonstrated MXSGT as a potential strategy for lung microvascular hyperpermeability and inflammatory reaction in ALI, and suggested that the beneficial role of MXSGT was correlated with toll-like receptor 4, Src, and NF-kappa B.

语种英语
所属项目编号2013ZX09402202
资助者Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China ; Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000343818400009
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60326
专题基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
3.State Adm Tradit Chinese Med China, Key Lab Microcirculat, Beijing, Peoples R China
4.State Adm Tradit Chinese Med China, Key Lab Stasis & Phlegm, Beijing, Peoples R China
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GB/T 7714
Ma, Li-Qian,Pan, Chun-Shui,Yang, Ning,et al. Posttreatment with Ma-Xing-Shi-Gan-Tang, a Chinese Medicine Formula, Ameliorates Lipopolysaccharide-Induced Lung Microvessel Hyperpermeability and Inflammatory Reaction in Rat[J]. MICROCIRCULATION,2014,21(7):649-663.
APA Ma, Li-Qian.,Pan, Chun-Shui.,Yang, Ning.,Liu, Yu-Ying.,Yan, Li.,...&Han, Jing-Yan.(2014).Posttreatment with Ma-Xing-Shi-Gan-Tang, a Chinese Medicine Formula, Ameliorates Lipopolysaccharide-Induced Lung Microvessel Hyperpermeability and Inflammatory Reaction in Rat.MICROCIRCULATION,21(7),649-663.
MLA Ma, Li-Qian,et al."Posttreatment with Ma-Xing-Shi-Gan-Tang, a Chinese Medicine Formula, Ameliorates Lipopolysaccharide-Induced Lung Microvessel Hyperpermeability and Inflammatory Reaction in Rat".MICROCIRCULATION 21.7(2014):649-663.
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