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Comparison of Urinary Biomarkers for Early Detection of Acute Kidney Injury After Cardiopulmonary Bypass Surgery in Infants and Young Children
Zheng, Jianyong1; Xiao, Yanyan1; Yao, Yong2; Xu, Guobin3; Li, Chunying4; Zhang, Qi4; Li, Haixia3; Han, Ling1
关键词Acute kidney injury Biomarker Cardiopulmonary bypass surgery Infants and young children
刊名PEDIATRIC CARDIOLOGY
2013-04-01
DOI10.1007/s00246-012-0563-6
34期:4页:880-886
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Pediatrics
研究领域[WOS]Cardiovascular System & Cardiology ; Pediatrics
关键词[WOS]CONGENITAL HEART-DISEASE ; GELATINASE-ASSOCIATED LIPOCALIN ; ADULT CARDIAC-SURGERY ; ACUTE-RENAL-FAILURE ; DIALYSIS ; NGAL
英文摘要

Acute kidney injury (AKI) is a potential complication for children with congenital heart disease (CHD) after cardiopulmonary bypass (CPB) surgery. This study was designed to investigate and compare the predictive values of urinary biomarkers for AKI after CPB surgery in infants and young children and to determine the optimal timing of testing and the cutoff value for each biomarker. The study prospectively enrolled 58 CHD children 3 years of age or younger who were undergoing CPB surgery. Urinary neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), microalbumin (MA), N-acetyl--D-glucosaminidase (NAG), alpha 1-microglobulin (alpha 1-MG), and creatinine (UCr) were measured at baseline and at various time points after surgery. Children who experienced AKI had more complex cardiac surgical procedures as evaluated by Risk Adjustment for Congenital Heart Surgery 1 (RACHS-1), longer CPB and aortic clamping times, and worse clinical outcomes than those who did not. In the AKI group, all five urinary biomarkers increased substantially and peaked at 4 h after surgery. In contrast, in the non-AKI group, they increased slightly or had no significant changes during the first 24 h. All the biomarkers had the best predictive performances at 4 h after surgery. At this time point, NAG had the minimum area under the curve (AUC) (0.747), which was significantly lower than that of the others (AUC, 0.82-0.85; P < 0.05). The optimal cutoff value of each biomarker was 290 ng/mg UCr for NAGL, 1,477 pg/mg UCr for IL-18, 400 mg/g UCr for MA, 225 U/g UCr for NAG, and 290 mg/g UCr for alpha 1-MG. In conclusion, urinary NGAL, IL-18, MA, and alpha 1-MG had similar predictive performances for the early detection of AKI after CPB surgery in infants and young children.

语种英语
WOS记录号WOS:000316957900014
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60331
专题北京大学第一临床医学院
作者单位1.Capital Med Univ, Beijing Anzhen Hosp, Dept Pediat Cardiol & Cardiac Surg, Beijing 100029, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat Nephrol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100871, Peoples R China
4.Peking Univ, Peoples Hosp, Cent Lab, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Jianyong,Xiao, Yanyan,Yao, Yong,et al. Comparison of Urinary Biomarkers for Early Detection of Acute Kidney Injury After Cardiopulmonary Bypass Surgery in Infants and Young Children[J]. PEDIATRIC CARDIOLOGY,2013,34(4):880-886.
APA Zheng, Jianyong.,Xiao, Yanyan.,Yao, Yong.,Xu, Guobin.,Li, Chunying.,...&Han, Ling.(2013).Comparison of Urinary Biomarkers for Early Detection of Acute Kidney Injury After Cardiopulmonary Bypass Surgery in Infants and Young Children.PEDIATRIC CARDIOLOGY,34(4),880-886.
MLA Zheng, Jianyong,et al."Comparison of Urinary Biomarkers for Early Detection of Acute Kidney Injury After Cardiopulmonary Bypass Surgery in Infants and Young Children".PEDIATRIC CARDIOLOGY 34.4(2013):880-886.
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