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学科主题: 临床医学
题名:
Rationale and design of the ETN-STEP (Early administration of Tirofiban in mid to high risk patients with non-ST elevation acute coronary syndrome referred for percutaneous coronary intervention) project: A multi-center, randomized, controlled clinic trial in Chinese patients
作者: Li, Jian-Ping1; Liu, Qun2; Huo, Yong1; ETN-STEP Investigators
关键词: Acute coronary syndrome ; Percutaneous coronary intervention ; Glycoprotein IIb/IIIa receptor ; Tirofiban ; Thrombolysis in myocardial infarction
刊名: JOURNAL OF GERIATRIC CARDIOLOGY
发表日期: 2012
DOI: 10.3724/SP.J.1263.2012.02272
卷: 9, 期:4, 页:375-378
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology
研究领域[WOS]: Cardiovascular System & Cardiology ; Geriatrics & Gerontology
关键词[WOS]: GLYCOPROTEIN IIB/IIIA INHIBITORS ; METAANALYSIS
英文摘要:

As a member of Glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors, Tirofiban had been shown to improve myocardial reperfusion and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI), but the optimal timing of administration of Tirofiban remains unclear. In order to compare the effects of upstream versus downstream administration of Tirofiban in Chinese patients with mid to high risk, non-ST elevation acute coronary syndrome (ACS) referred for PCI, a multi-center, randomized, controlled, prospective study will be conducted. A total of 500 mid to high risk, non-ST-segment elevation myocardial infarction (NSTEMI) ACS patients will be recruited for this study. Patients will be randomized to Tirofiban upstream administration group (initiated 12 h before PCI) and Tirofiban downstream administration group (initiated at cath-lab after angiography). Thrombolysis in myocardial infarction (TIMI) flow grades, TIMI myocardial perfusion grades (TMPG), and Corrected TIMI frame counting (CTFC) before and after PCI, as well as clinical outcomes during the hospital stay, and within 30 days after PCI will be compared between the two groups. This study will provide evidence on the optimal timing for initiating administration of Tirofiban in mid to high NSTEMI ACS subjects undergoing PCI. J Geriatr Cardiol 2012; 9: 375-378. doi: 10.3724/SP.J.1263.2012.02272

语种: 英语
WOS记录号: WOS:000316609200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60332
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China
2.Beijing Hypertens League Inst, Beijing 100040, Peoples R China

Recommended Citation:
Li, Jian-Ping,Liu, Qun,Huo, Yong,et al. Rationale and design of the ETN-STEP (Early administration of Tirofiban in mid to high risk patients with non-ST elevation acute coronary syndrome referred for percutaneous coronary intervention) project: A multi-center, randomized, controlled clinic trial in Chinese patients[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2012,9(4):375-378.
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