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Rationale and design of the ETN-STEP (Early administration of Tirofiban in mid to high risk patients with non-ST elevation acute coronary syndrome referred for percutaneous coronary intervention) project: A multi-center, randomized, controlled clinic trial in Chinese patients
Li, Jian-Ping1; Liu, Qun2; Huo, Yong1; ETN-STEP Investigators
关键词Acute coronary syndrome Percutaneous coronary intervention Glycoprotein IIb/IIIa receptor Tirofiban Thrombolysis in myocardial infarction
刊名JOURNAL OF GERIATRIC CARDIOLOGY
2012
DOI10.3724/SP.J.1263.2012.02272
9期:4页:375-378
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology
研究领域[WOS]Cardiovascular System & Cardiology ; Geriatrics & Gerontology
关键词[WOS]GLYCOPROTEIN IIB/IIIA INHIBITORS ; METAANALYSIS
英文摘要

As a member of Glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors, Tirofiban had been shown to improve myocardial reperfusion and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI), but the optimal timing of administration of Tirofiban remains unclear. In order to compare the effects of upstream versus downstream administration of Tirofiban in Chinese patients with mid to high risk, non-ST elevation acute coronary syndrome (ACS) referred for PCI, a multi-center, randomized, controlled, prospective study will be conducted. A total of 500 mid to high risk, non-ST-segment elevation myocardial infarction (NSTEMI) ACS patients will be recruited for this study. Patients will be randomized to Tirofiban upstream administration group (initiated 12 h before PCI) and Tirofiban downstream administration group (initiated at cath-lab after angiography). Thrombolysis in myocardial infarction (TIMI) flow grades, TIMI myocardial perfusion grades (TMPG), and Corrected TIMI frame counting (CTFC) before and after PCI, as well as clinical outcomes during the hospital stay, and within 30 days after PCI will be compared between the two groups. This study will provide evidence on the optimal timing for initiating administration of Tirofiban in mid to high NSTEMI ACS subjects undergoing PCI. J Geriatr Cardiol 2012; 9: 375-378. doi: 10.3724/SP.J.1263.2012.02272

语种英语
WOS记录号WOS:000316609200009
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60332
专题北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China
2.Beijing Hypertens League Inst, Beijing 100040, Peoples R China
推荐引用方式
GB/T 7714
Li, Jian-Ping,Liu, Qun,Huo, Yong,et al. Rationale and design of the ETN-STEP (Early administration of Tirofiban in mid to high risk patients with non-ST elevation acute coronary syndrome referred for percutaneous coronary intervention) project: A multi-center, randomized, controlled clinic trial in Chinese patients[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2012,9(4):375-378.
APA Li, Jian-Ping,Liu, Qun,Huo, Yong,&ETN-STEP Investigators.(2012).Rationale and design of the ETN-STEP (Early administration of Tirofiban in mid to high risk patients with non-ST elevation acute coronary syndrome referred for percutaneous coronary intervention) project: A multi-center, randomized, controlled clinic trial in Chinese patients.JOURNAL OF GERIATRIC CARDIOLOGY,9(4),375-378.
MLA Li, Jian-Ping,et al."Rationale and design of the ETN-STEP (Early administration of Tirofiban in mid to high risk patients with non-ST elevation acute coronary syndrome referred for percutaneous coronary intervention) project: A multi-center, randomized, controlled clinic trial in Chinese patients".JOURNAL OF GERIATRIC CARDIOLOGY 9.4(2012):375-378.
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