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Anti-inflammatory Coumarin and Benzocoumarin Derivatives from Murraya alata
Lv, Hai-Ning1; Wang, Shu2; Zeng, Ke-Wu1; Li, Jun3; Guo, Xiao-Yu1; Ferreira, Daneel4,5; Zjawiony, Jordan K.4,5; Tu, Peng-Fei1; Jiang, Yong1
刊名JOURNAL OF NATURAL PRODUCTS
2015-02-01
DOI10.1021/np500851u
78期:2页:279-285
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Natural Sciences Foundation of China (NSFC) ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Natural Sciences Foundation of China (NSFC) ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]ABSOLUTE-CONFIGURATION ; STRUCTURE ELUCIDATION ; NITRIC-OXIDE ; PANICULATA ; LEAVES ; OMPHALOCARPA ; EXOTICA ; STEREOCHEMISTRY ; CONSTITUENTS ; OMPHAMURIN
英文摘要

Two new rare 8-methylbenzo[h]coumarins, muralatins A and B (1, 2), nine new C-8-substituted coumarins, muralatins CK (3-11), and 22 known analogues (12-33) were isolated from the leaves of Murraya alata. The absolute configurations of compounds 5, 11, 23, 24, 27, 30, and 33 were assigned via comparison of their specific rotations, by Moshers method, and by single-crystal X-ray diffraction and electronic circular dichroism (ECD) data of the in situ formed transition metal complexes. A putative biosynthesis pathway to 1 and 2 is proposed, and the chemical synthesis of 1 was accomplished through electrocyclization of 5,7-dimethoxy-8-[(Z)-3-methylbut-1,3-dienyl)]coumarin (12). Compounds 1, 2, 8, 12, and 31 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values of 6.014.5 mu M.

语种英语
所属项目编号81222051 ; 81473106 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
资助者National Natural Sciences Foundation of China (NSFC) ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Natural Sciences Foundation of China (NSFC) ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号WOS:000350328600015
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60333
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Logist Coll Chinese Peoples Armed Police Forces, Dept Med Chem & Pharmaceut Anal, Tianjin 300162, Peoples R China
3.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
4.Univ Mississippi, Dept Biomol Sci, Div Pharmacognosy, University, MS 38677 USA
5.Univ Mississippi, Pharmaceut Sci Res Inst, Sch Pharm, University, MS 38677 USA
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GB/T 7714
Lv, Hai-Ning,Wang, Shu,Zeng, Ke-Wu,et al. Anti-inflammatory Coumarin and Benzocoumarin Derivatives from Murraya alata[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(2):279-285.
APA Lv, Hai-Ning.,Wang, Shu.,Zeng, Ke-Wu.,Li, Jun.,Guo, Xiao-Yu.,...&Jiang, Yong.(2015).Anti-inflammatory Coumarin and Benzocoumarin Derivatives from Murraya alata.JOURNAL OF NATURAL PRODUCTS,78(2),279-285.
MLA Lv, Hai-Ning,et al."Anti-inflammatory Coumarin and Benzocoumarin Derivatives from Murraya alata".JOURNAL OF NATURAL PRODUCTS 78.2(2015):279-285.
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