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学科主题: 临床医学
题名:
The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures
作者: Zhang, Dandan1; Ding, Haiyan2; Liu, Lili3; Hou, Xinlin3; Sun, Guoyu3; Li, Lei4; Liu, Yunzhe1; Zhou, Congle3; Gu, Ruolei5; Luo, Yuejia1
刊名: PLOS ONE
发表日期: 2013-11-13
DOI: 10.1371/journal.pone.0078960
卷: 8, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HYPOXIC-ISCHEMIC ENCEPHALOPATHY ; PREDICTIVE-VALUE ; PRETERM INFANTS ; NEUROLOGIC EXAMINATION ; BIRTH ASPHYXIA ; ELECTROENCEPHALOGRAPHY ; AEEG ; HYPOTHERMIA ; NEWBORN ; BORN
英文摘要:

Neonatal seizures pose a high risk for adverse outcome in survived infants. While the prognostic value of amplitude-integrated electroencephalogram (aEEG) is well established in neonates with encephalopathy and asphyxia, neonatal seizure studies focusing on the direct correlation between early aEEG measurement and subsequent neurologic outcome are scarce. In this study, the prognostic value of aEEG features was systematically analyzed in 143 full-term neonates to identify prognostic indicators of neurodevelopmental outcome. Neonatal aEEG features of background pattern, cyclicity, and seizure activity, as well as the etiology of neonatal seizures, were significantly associated with neurodevelopmental outcome at one year of age. aEEG background pattern was highly associated with neurologic outcomes (chi(2) = 116.9), followed by aEEG cyclicity (chi(2) = 87.2) and seizure etiology (chi(2) = 79.3). Multiple linear regression showed that the four predictors explained 71.2% of the variation in neurological outcome, with standardized beta coefficients of 0.44, 0.24, 0.22, and 0.14 for the predictors of aEEG background pattern, cyclicity, etiology, and aEEG seizure activity, respectively. This clinically applicable scoring system based on etiology and three aEEG indices would allow pediatricians to assess the risk for neurodevelopmental impairment and facilitate an early intervention in newborns developing seizures.

语种: 英语
所属项目编号: 31300867 ; 31300847 ; 91132704
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000327254700073
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60337
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Shenzhen Univ, Inst Affect & Social Neurosci, Shenzhen, Peoples R China
2.Tsinghua Univ, Dept Biomed Engn, Beijing 100084, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
4.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Cryogen, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China

Recommended Citation:
Zhang, Dandan,Ding, Haiyan,Liu, Lili,et al. The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures[J]. PLOS ONE,2013,8(11).
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