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学科主题临床医学
Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study
Nakagawa, Masatoshi1,4; Choi, Yoon Young1; An, Ji Yeong1,6; Chung, Hyunsoo3; Seo, Sang Hyuk1,7; Shin, Hyun Beak1; Bang, Hui-Jae1; Li, Shuangxi1,5; Kim, Hyung-Il1; Cheong, Jae-Ho1; Hyung, Woo Jin1; Noh, Sung Hoon1,2
关键词Early gastric cancer Lymph node metastasis Preoperative prediction
刊名BMC CANCER
2015-12-01
DOI10.1186/s12885-015-1940-3
15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ENDOSCOPIC RESECTION ; FORCEPS BIOPSY ; DISSECTION ; DIAGNOSIS ; RISK ; SIZE ; DYSPLASIA ; EUS
英文摘要

Background: The relationship between pathological factors and lymph node metastasis of pathological stage early gastric cancer has been extensively investigated. By contrast, the relationship between preoperative factors and lymph node metastasis of clinical stage early gastric cancer has not been investigated. The present study was to investigate discrepancies between preoperative and postoperative values.

Methods: From January 2011 to December 2013, 1042 patients with clinical stage early gastric cancer who underwent gastrectomy with lymphadenectomy were enrolled. Preoperative and postoperative values were collected for subsequent analysis. Receiver operating characteristics curves were computed using independent predictive factors.

Results: Several discrepancies were observed between preoperative and postoperative values, including existence of ulcer, gross type, and histology (all McNemar p-values were < 0.001). Multivariate analyses identified the following independent predictive factors for lymph node metastasis: postoperative values including age (p = 0.002), tumor size (p < 0.001), and tumor depth (p < 0.001); preoperative values including age (p = 0.017), existence of ulcer (p = 0.037), tumor size (p = 0.009), and prediction of the presence of lymph node metastasis in computed tomography scans (p = 0.002). These postoperative and preoperative independent predictive factors produced areas under the receiver operating characteristics curves of 0.824 and 0.660, respectively.

Conclusions: Surgeons need to be aware of limitations in preoperative predictions of the presence of lymph node metastasis for clinical stage early gastric cancer.

语种英语
WOS记录号WOS:000365490600003
项目编号1020390 ; 1320360
资助机构National R&amp ; D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60340
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位1.Yonsei Univ, Coll Med, Hlth Syst, Dept Surg, Seoul 120752, South Korea
2.Yonsei Univ, Coll Med, Hlth Syst, Brain Korea 21 Plus Project Med Sci, Seoul 120752, South Korea
3.Yonsei Univ, Coll Med, Hlth Syst, Dept Internal Med,Inst Gastroenterol, Seoul 120752, South Korea
4.Tokyo Med & Dent Univ, Dept Gastr Surg, Tokyo, Japan
5.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Gastrointestinal Surg, Beijing 100871, Peoples R China
6.Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul 06351, South Korea
7.Inje Univ, Coll Med, Busan Paik Hosp, Dept Surg, Busan, South Korea
推荐引用方式
GB/T 7714
Nakagawa, Masatoshi,Choi, Yoon Young,An, Ji Yeong,et al. Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study[J]. BMC CANCER,2015,15.
APA Nakagawa, Masatoshi.,Choi, Yoon Young.,An, Ji Yeong.,Chung, Hyunsoo.,Seo, Sang Hyuk.,...&Noh, Sung Hoon.(2015).Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study.BMC CANCER,15.
MLA Nakagawa, Masatoshi,et al."Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study".BMC CANCER 15(2015).
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