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IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study
作者: Nakagawa, Masatoshi1,4; Choi, Yoon Young1; An, Ji Yeong1,6; Chung, Hyunsoo3; Seo, Sang Hyuk1,7; Shin, Hyun Beak1; Bang, Hui-Jae1; Li, Shuangxi1,5; Kim, Hyung-Il1; Cheong, Jae-Ho1; Hyung, Woo Jin1; Noh, Sung Hoon1,2
关键词: Early gastric cancer ; Lymph node metastasis ; Preoperative prediction
刊名: BMC CANCER
发表日期: 2015-12-01
DOI: 10.1186/s12885-015-1940-3
卷: 15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ENDOSCOPIC RESECTION ; FORCEPS BIOPSY ; DISSECTION ; DIAGNOSIS ; RISK ; SIZE ; DYSPLASIA ; EUS
英文摘要:

Background: The relationship between pathological factors and lymph node metastasis of pathological stage early gastric cancer has been extensively investigated. By contrast, the relationship between preoperative factors and lymph node metastasis of clinical stage early gastric cancer has not been investigated. The present study was to investigate discrepancies between preoperative and postoperative values.

Methods: From January 2011 to December 2013, 1042 patients with clinical stage early gastric cancer who underwent gastrectomy with lymphadenectomy were enrolled. Preoperative and postoperative values were collected for subsequent analysis. Receiver operating characteristics curves were computed using independent predictive factors.

Results: Several discrepancies were observed between preoperative and postoperative values, including existence of ulcer, gross type, and histology (all McNemar p-values were < 0.001). Multivariate analyses identified the following independent predictive factors for lymph node metastasis: postoperative values including age (p = 0.002), tumor size (p < 0.001), and tumor depth (p < 0.001); preoperative values including age (p = 0.017), existence of ulcer (p = 0.037), tumor size (p = 0.009), and prediction of the presence of lymph node metastasis in computed tomography scans (p = 0.002). These postoperative and preoperative independent predictive factors produced areas under the receiver operating characteristics curves of 0.824 and 0.660, respectively.

Conclusions: Surgeons need to be aware of limitations in preoperative predictions of the presence of lymph node metastasis for clinical stage early gastric cancer.

语种: 英语
所属项目编号: 1020390 ; 1320360
项目资助者: National R&amp ; D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea
WOS记录号: WOS:000365490600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60340
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Yonsei Univ, Coll Med, Hlth Syst, Dept Surg, Seoul 120752, South Korea
2.Yonsei Univ, Coll Med, Hlth Syst, Brain Korea 21 Plus Project Med Sci, Seoul 120752, South Korea
3.Yonsei Univ, Coll Med, Hlth Syst, Dept Internal Med,Inst Gastroenterol, Seoul 120752, South Korea
4.Tokyo Med & Dent Univ, Dept Gastr Surg, Tokyo, Japan
5.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Gastrointestinal Surg, Beijing 100871, Peoples R China
6.Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul 06351, South Korea
7.Inje Univ, Coll Med, Busan Paik Hosp, Dept Surg, Busan, South Korea

Recommended Citation:
Nakagawa, Masatoshi,Choi, Yoon Young,An, Ji Yeong,et al. Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study[J]. BMC CANCER,2015,15.
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