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学科主题: 基础医学
题名:
Physical coupling between ryanodine receptor-calcium release channels
作者: Yin, CC; Blayney, LM; Lai, FA
关键词: Ca2+-release channel ; Ca2+ signaling ; physical coupling ; ryanodine receptor
刊名: JOURNAL OF MOLECULAR BIOLOGY
发表日期: 2005-06-10
DOI: 10.1016/j.jmb.2005.04.002
卷: 349, 期:3, 页:538-546
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: SKELETAL-MUSCLE ; SARCOPLASMIC-RETICULUM ; BINDING-PROTEIN ; ELECTRON CRYOMICROSCOPY ; HEART-MUSCLE ; CA2+ SPARKS ; CONTRACTION ; CELLS ; FEET ; RECONSTITUTION
英文摘要:

Ryanodine receptor-calcium release channels play a pivotal role in the calcium signaling that mediates muscle excitation-contraction coupling. Their membrane organization into regular patterns, functional gating studies and theoretical analysis of receptor clustering have led to models that invoke allosteric interaction between individual channel oligomers as a critical mechanism for control of calcium release. Here we show that in reconstituted "checkerboard-like" lattices that mimic in situ membrane channel arrays, each oligomer is interlocked physically with four adjacent oligomers vi. a a specific domain-domain interaction. Direct physical coupling between ryanodine receptors provides structural evidence for an inter-oligomer allosteric mechanism in channel regulation. Therefore, in addition to established cytosolic and luminal regulation of function, these observations indicate that channel-channel communication through physical coupling provides a novel mode of regulation of intracellular calcium release channels. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000229401700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60341
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
2.Univ Cardiff Wales, Coll Med, Wales Heart Res Inst, Cardiff CF14 4XN, Wales

Recommended Citation:
Yin, CC,Blayney, LM,Lai, FA. Physical coupling between ryanodine receptor-calcium release channels[J]. JOURNAL OF MOLECULAR BIOLOGY,2005,349(3):538-546.
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