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学科主题基础医学
Physical coupling between ryanodine receptor-calcium release channels
Yin, CC; Blayney, LM; Lai, FA
关键词Ca2+-release channel Ca2+ signaling physical coupling ryanodine receptor
刊名JOURNAL OF MOLECULAR BIOLOGY
2005-06-10
DOI10.1016/j.jmb.2005.04.002
349期:3页:538-546
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]SKELETAL-MUSCLE ; SARCOPLASMIC-RETICULUM ; BINDING-PROTEIN ; ELECTRON CRYOMICROSCOPY ; HEART-MUSCLE ; CA2+ SPARKS ; CONTRACTION ; CELLS ; FEET ; RECONSTITUTION
英文摘要

Ryanodine receptor-calcium release channels play a pivotal role in the calcium signaling that mediates muscle excitation-contraction coupling. Their membrane organization into regular patterns, functional gating studies and theoretical analysis of receptor clustering have led to models that invoke allosteric interaction between individual channel oligomers as a critical mechanism for control of calcium release. Here we show that in reconstituted "checkerboard-like" lattices that mimic in situ membrane channel arrays, each oligomer is interlocked physically with four adjacent oligomers vi. a a specific domain-domain interaction. Direct physical coupling between ryanodine receptors provides structural evidence for an inter-oligomer allosteric mechanism in channel regulation. Therefore, in addition to established cytosolic and luminal regulation of function, these observations indicate that channel-channel communication through physical coupling provides a novel mode of regulation of intracellular calcium release channels. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000229401700008
引用统计
被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60341
专题北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
2.Univ Cardiff Wales, Coll Med, Wales Heart Res Inst, Cardiff CF14 4XN, Wales
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Yin, CC,Blayney, LM,Lai, FA. Physical coupling between ryanodine receptor-calcium release channels[J]. JOURNAL OF MOLECULAR BIOLOGY,2005,349(3):538-546.
APA Yin, CC,Blayney, LM,&Lai, FA.(2005).Physical coupling between ryanodine receptor-calcium release channels.JOURNAL OF MOLECULAR BIOLOGY,349(3),538-546.
MLA Yin, CC,et al."Physical coupling between ryanodine receptor-calcium release channels".JOURNAL OF MOLECULAR BIOLOGY 349.3(2005):538-546.
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