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学科主题临床医学
Hemorheological changes in cerebral circulation of rabbits with acute carbon monoxide poisoning
Wang, Xifu1; Wang, Xianwei2; Wen, Tao3; Guan, Li1; Zhang, Yanlin1; Zhu, Mingxia1; Zhao, Jinyuan1
关键词Carbon monoxide poisoning hemorheology rabbit
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2009
DOI10.3233/CH-2009-1239
43期:4页:271-282
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]SHEAR-FLOW FIELD ; LIPID-PEROXIDATION ; BLOOD-VISCOSITY ; EDINBURGH ARTERY ; DISEASE ; DEFORMABILITY ; OXYGEN ; ENCEPHALOPATHY ; ERYTHROCYTES ; AGGREGATION
英文摘要

Carbon monoxide (CO) poisoning is a leading cause of poison-related morbidity and mortality. The severe complication of delayed neuropsychiatric sequelae seriously affects patient′s living quality, but its mechanism remains controversial. In this study, we established an animal model by intraperitoneal injection of CO in rabbits at regular interval and kept the carboxyhemoglobin (HbCO) level in blood above 50% for at least 24 h. We investigated the dynamic changes in the hemorheological and coagulative properties of blood taken from venae jugularis interna before CO injection and at 30 min, 1-5 days after the last CO exposure. We found that RBC count, hemoglobin (Hb) concentration, and hematocrit (Hct) increased on 1 day and remained high level till 5 day. Whole blood viscosities at different shear rates decreased significantly at 30 min and then increased 1 day later until day 4. RBC deformation index (DI) and aggregation index decreased at 30 min and recovered to normal on day 3. Plasma viscosity and fibrinogen augmented from 30 min until day 5. Prothrombin time (PT) and active partial thromboplastin time (APTT) prolonged remarkably at 30 min and went back to normal on 3 day, plasma [Ca(2+)] decreased at 30 min and approached to normal level on 3 day. The level of malondialdehyde (MDA) in RBCs at 30 min was significantly higher than that of control and recovered to normal on day 3. Our results suggest that the changes in hemorheology participate in the development of acute CO poisoning, which may play a role in delayed encephalopathy after acute CO poisoning.

语种英语
WOS记录号WOS:000272519600001
项目编号0471439
资助机构National Science Foundation in China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60343
专题北京大学第三临床医学院_职业病科
作者单位1.Capital Univ, You An Hosp, Beijing, Peoples R China
2.Peking Univ, Res Ctr Occupat Med, Hosp 3, Beijing 1001901, Peoples R China
3.Peking Univ, Dept Biophys, Hlth Sci Ctr, Beijing 1001901, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xifu,Wang, Xianwei,Wen, Tao,et al. Hemorheological changes in cerebral circulation of rabbits with acute carbon monoxide poisoning[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2009,43(4):271-282.
APA Wang, Xifu.,Wang, Xianwei.,Wen, Tao.,Guan, Li.,Zhang, Yanlin.,...&Zhao, Jinyuan.(2009).Hemorheological changes in cerebral circulation of rabbits with acute carbon monoxide poisoning.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,43(4),271-282.
MLA Wang, Xifu,et al."Hemorheological changes in cerebral circulation of rabbits with acute carbon monoxide poisoning".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 43.4(2009):271-282.
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