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学科主题: 临床医学
题名:
Hemorheological changes in cerebral circulation of rabbits with acute carbon monoxide poisoning
作者: Wang, Xifu1; Wang, Xianwei2; Wen, Tao3; Guan, Li1; Zhang, Yanlin1; Zhu, Mingxia1; Zhao, Jinyuan1
关键词: Carbon monoxide poisoning ; hemorheology ; rabbit
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2009
DOI: 10.3233/CH-2009-1239
卷: 43, 期:4, 页:271-282
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: SHEAR-FLOW FIELD ; LIPID-PEROXIDATION ; BLOOD-VISCOSITY ; EDINBURGH ARTERY ; DISEASE ; DEFORMABILITY ; OXYGEN ; ENCEPHALOPATHY ; ERYTHROCYTES ; AGGREGATION
英文摘要:

Carbon monoxide (CO) poisoning is a leading cause of poison-related morbidity and mortality. The severe complication of delayed neuropsychiatric sequelae seriously affects patient′s living quality, but its mechanism remains controversial. In this study, we established an animal model by intraperitoneal injection of CO in rabbits at regular interval and kept the carboxyhemoglobin (HbCO) level in blood above 50% for at least 24 h. We investigated the dynamic changes in the hemorheological and coagulative properties of blood taken from venae jugularis interna before CO injection and at 30 min, 1-5 days after the last CO exposure. We found that RBC count, hemoglobin (Hb) concentration, and hematocrit (Hct) increased on 1 day and remained high level till 5 day. Whole blood viscosities at different shear rates decreased significantly at 30 min and then increased 1 day later until day 4. RBC deformation index (DI) and aggregation index decreased at 30 min and recovered to normal on day 3. Plasma viscosity and fibrinogen augmented from 30 min until day 5. Prothrombin time (PT) and active partial thromboplastin time (APTT) prolonged remarkably at 30 min and went back to normal on 3 day, plasma [Ca(2+)] decreased at 30 min and approached to normal level on 3 day. The level of malondialdehyde (MDA) in RBCs at 30 min was significantly higher than that of control and recovered to normal on day 3. Our results suggest that the changes in hemorheology participate in the development of acute CO poisoning, which may play a role in delayed encephalopathy after acute CO poisoning.

语种: 英语
所属项目编号: 0471439
项目资助者: National Science Foundation in China
WOS记录号: WOS:000272519600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60343
Appears in Collections:北京大学第三临床医学院_职业病科_期刊论文

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作者单位: 1.Capital Univ, You An Hosp, Beijing, Peoples R China
2.Peking Univ, Res Ctr Occupat Med, Hosp 3, Beijing 1001901, Peoples R China
3.Peking Univ, Dept Biophys, Hlth Sci Ctr, Beijing 1001901, Peoples R China

Recommended Citation:
Wang, Xifu,Wang, Xianwei,Wen, Tao,et al. Hemorheological changes in cerebral circulation of rabbits with acute carbon monoxide poisoning[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2009,43(4):271-282.
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