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学科主题临床医学
Detecting Misery Perfusion in Unilateral Steno-Occlusive Disease of the Internal Carotid Artery or Middle Cerebral Artery by MR Imaging
Xie, S.1; Hui, L. H.1; Xiao, J. X.1; Zhang, X. D.3; Peng, Q.2
刊名AMERICAN JOURNAL OF NEURORADIOLOGY
2011-09-01
DOI10.3174/ajnr.A2523
32期:8页:1504-1509
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; OXYGEN EXTRACTION FRACTION ; HEMODYNAMIC IMPAIRMENT ; MAGNETIC-RESONANCE ; BLOOD-VOLUME ; FLOW ; ISCHEMIA ; STROKE ; CIRCULATION ; REACTIVITY
英文摘要

BACKGROUND AND PURPOSE: Elevated OEF is a surrogate for misery perfusion. Our aim was to detect misery perfusion in patients with unilateral steno-occlusive disease of the ICA or MCA by using T2*-based MR imaging and to determine the relationship between brain ischemia and OEF.

MATERIALS AND METHODS: Twenty-three patients with unilateral steno-occlusive disease of the ICA or MCA and 8 healthy volunteers were included in this study. Hemodynamic information was obtained in all subjects by MR imaging. Three regions of interest were placed in the anterior, middle, and posterior parts of the brain bilaterally to measure the OEF and CBF values, The OEFs of the regions of interest in the hemispheres ipsilateral and contralateral to the vascular lesions were compared. Brain regions with OEF greater than that in controls were determined as misery perfusion in patients. The association of vascular lesions, rCBF, and the presence of territory infarction with elevated OEF was investigated.

RESULTS: There was a statistically significant difference in OEF between the ipsilateral and contralateral hemispheres in the patients (t = 3.632, P = .001). Fourteen regions of interest with misery perfusion were determined in the ipsilateral hemispheres, while 3 regions with elevated OEFs were found in the contralateral hemispheres. In the ipsilateral hemispheres, decreased rCBF was associated with elevated OEF (r = -0.451, P < .001). Patients with territory infarction had more regions of interest with misery perfusion than patients without territory infarction (X-2 = 3.889, P = .049).

CONCLUSIONS: By using the MR imaging technique, misery perfusion demonstrated as elevated OEF was detected in patients with severe atherosclerotic ICA or MCA disease. Identification of misery perfusion with MR imaging may be helpful in the evaluation of brain ischemia.

语种英语
WOS记录号WOS:000295706200024
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60344
专题北京大学第一临床医学院_放射治疗科
作者单位1.Peking Univ First Hosp, Dept Radiol, Beijing 100034, Peoples R China
2.Peking Univ First Hosp, Dept Neurol, Beijing 100034, Peoples R China
3.Peking Univ, Adv Acad Interdisciplinary Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xie, S.,Hui, L. H.,Xiao, J. X.,et al. Detecting Misery Perfusion in Unilateral Steno-Occlusive Disease of the Internal Carotid Artery or Middle Cerebral Artery by MR Imaging[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2011,32(8):1504-1509.
APA Xie, S.,Hui, L. H.,Xiao, J. X.,Zhang, X. D.,&Peng, Q..(2011).Detecting Misery Perfusion in Unilateral Steno-Occlusive Disease of the Internal Carotid Artery or Middle Cerebral Artery by MR Imaging.AMERICAN JOURNAL OF NEURORADIOLOGY,32(8),1504-1509.
MLA Xie, S.,et al."Detecting Misery Perfusion in Unilateral Steno-Occlusive Disease of the Internal Carotid Artery or Middle Cerebral Artery by MR Imaging".AMERICAN JOURNAL OF NEURORADIOLOGY 32.8(2011):1504-1509.
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