北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population
作者: Chen, Ling1; Jia, Liyun1; Wang, Ningli1; Tang, Guangxian2; Zhang, Chun3; Fan, Sujie4; Liu, Wenru4; Meng, Hailin5; Zeng, Wotan6; Liu, Ningpu1; Wang, Huaizhou1; Jia, Hongyan1
刊名: MOLECULAR VISION
发表日期: 2009-11-14
卷: 15, 期:250-52, 页:2349-2357
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Ophthalmology
研究领域[WOS]: Biochemistry & Molecular Biology ; Ophthalmology
关键词[WOS]: OPEN-ANGLE GLAUCOMA ; COMMON SEQUENCE VARIANTS ; PSEUDOEXFOLIATION SYNDROME ; GENE POLYMORPHISMS ; JAPANESE POPULATION ; SOUTHERN INDIA ; UNITED-STATES ; PREVALENCE ; ASSOCIATION ; EYE
英文摘要:

Purpose: To evaluate the association profiles of the lysyl oxidase-like 1 (LOXL1) gene polymorphisms with exfoliation syndrome in a Chinese population.

Methods: Fifty unrelated patients with exfoliation syndrome and 125 control subjects were included. Genotypes of the three single nucleotide polymorphisms (SNPs) of LOXL1 (rs1048661, rs3825942, and rs2165241) were analyzed by direct sequencing, and a case-control association study was performed.

Results: The three SNPs were significantly associated with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) individually. After controlling for rs3825942 and rs2165241, the association between rs1048661 and XFS/XFG remained significant (p=3.6x10(-7)). At this SNP, the T allele and TT genotype conferred a 7.59-(95% confidence interval [CI]: 3.87-14.89, p=6.95x10(-11)) and 8.69-(95% CI: 4.15-18.20, p<1.00x10(-7)) fold increased risk to the disease. The alleles of T at rs1048661 and C at rs2165241 were found to be risk alleles in Chinese subjects, which were opposite to Caucasian individuals. The haplotypes T-G, defined by SNPs rs1048661 and rs3825942, and T-C by SNPs rs1048661 and rs2165241, were also significantly associated with the disorder. However when the genotypic or allelic frequencies of the three SNPs were compared between XFS and XFG, no significant difference was detected.

Conclusions: LOXL1 is a susceptibility gene of XFS/XFG in the Chinese population, and the association is mainly attributed to SNP rs1048661. The risk alleles of rs1048661 and rs2165241 in Chinese subjects were found to be opposite to that of Caucasians. The genotypic and allelic distributions of these SNPs are similar between XFS and XFG.

语种: 英语
WOS记录号: WOS:000272475000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60357
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.XingTai Eye Hosp, Dept Ophthalmol, Xingtai, Peoples R China
2.Peking Univ, Hosp 3, Ctr Eye, Beijing 100871, Peoples R China
3.Handan Eye Hosp, Dept Ophthalmol, Handan, Peoples R China
4.Anyang Eye Hosp, Dept Ophthalmol, Anyang, Peoples R China
5.Chinese Natl Human Genome Ctr, Beijing, Peoples R China
6.Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China

Recommended Citation:
Chen, Ling,Jia, Liyun,Wang, Ningli,et al. Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population[J]. MOLECULAR VISION,2009,15(250-52):2349-2357.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Ling]'s Articles
[Jia, Liyun]'s Articles
[Wang, Ningli]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Ling]‘s Articles
[Jia, Liyun]‘s Articles
[Wang, Ningli]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace