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学科主题口腔医学
Osteoclast Deficiency Contributes to Temporomandibular Joint Ankylosed Bone Mass Formation
He, L. H.1; Xiao, E.1; Duan, D. H.2; Gan, Y. H.3,4; Zhang, Y.1
关键词osteoclastogenesis osteogenesis bone remodeling bone marrow stem cells bone marrow myelomonocytes pathogenesis
刊名JOURNAL OF DENTAL RESEARCH
2015-10-01
DOI10.1177/0022034515599149
94期:10页:1392-1400
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]MICRO-COMPUTED TOMOGRAPHY ; MARROW-DERIVED CELLS ; CHIMERIC MOUSE MODEL ; FRACTURE REPAIR ; STROMAL CELLS ; OSTEOBLAST ; RANKL ; OSTEOPOROSIS ; ALENDRONATE ; MANAGEMENT
英文摘要

Ankylosed bone mass in temporomandibular joint ankylosis (TMJA) is an important factor affecting mouth-opening limitation. However, the mechanism underlying the occurrence of ankylosed bone mass remains unknown. Research has shown that osteoblasts and osteoclasts maintain balance in bone remodeling. Thus, we hypothesized that aberrant osteoclastogenesis and osteogenesis may be involved in the occurrence of ankylosed bone mass in TMJA. In this study, we characterized the osteogenesis of bone marrow stem cells and the osteoclastogenesis of myelomonocyte in clinical specimens of TMJA and normal controls. Results showed that, compared with control bone marrow stem cells, TMJA bone marrow stem cells had lower proliferative and osteogenic capacities. The number of osteoclasts in the ankylosed bone mass group dramatically decreased, and myelomonocyte osteoclastogenic potential was impaired. The RANKL/OPG ratio of the ankylosed bone mass group was lower than that of the control group. Thus, our study suggests that osteoclast deficiency may be an important factor affecting bone mass ankylosis.

语种英语
所属项目编号81170936 ; 7152155
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号WOS:000361819400010
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60364
专题北京大学口腔医学院_综合治疗科
作者单位1.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Dept Gen Dent, Beijing 100081, Peoples R China
3.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
4.Peking Univ Sch & Hosp Stomatol, Ctr TMD & Orofacial Pain, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
He, L. H.,Xiao, E.,Duan, D. H.,et al. Osteoclast Deficiency Contributes to Temporomandibular Joint Ankylosed Bone Mass Formation[J]. JOURNAL OF DENTAL RESEARCH,2015,94(10):1392-1400.
APA He, L. H.,Xiao, E.,Duan, D. H.,Gan, Y. H.,&Zhang, Y..(2015).Osteoclast Deficiency Contributes to Temporomandibular Joint Ankylosed Bone Mass Formation.JOURNAL OF DENTAL RESEARCH,94(10),1392-1400.
MLA He, L. H.,et al."Osteoclast Deficiency Contributes to Temporomandibular Joint Ankylosed Bone Mass Formation".JOURNAL OF DENTAL RESEARCH 94.10(2015):1392-1400.
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