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学科主题: 口腔医学
题名:
Osteoclast Deficiency Contributes to Temporomandibular Joint Ankylosed Bone Mass Formation
作者: He, L. H.1; Xiao, E.1; Duan, D. H.2; Gan, Y. H.3,4; Zhang, Y.1
关键词: osteoclastogenesis ; osteogenesis ; bone remodeling ; bone marrow stem cells ; bone marrow myelomonocytes ; pathogenesis
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2015-10-01
DOI: 10.1177/0022034515599149
卷: 94, 期:10, 页:1392-1400
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: MICRO-COMPUTED TOMOGRAPHY ; MARROW-DERIVED CELLS ; CHIMERIC MOUSE MODEL ; FRACTURE REPAIR ; STROMAL CELLS ; OSTEOBLAST ; RANKL ; OSTEOPOROSIS ; ALENDRONATE ; MANAGEMENT
英文摘要:

Ankylosed bone mass in temporomandibular joint ankylosis (TMJA) is an important factor affecting mouth-opening limitation. However, the mechanism underlying the occurrence of ankylosed bone mass remains unknown. Research has shown that osteoblasts and osteoclasts maintain balance in bone remodeling. Thus, we hypothesized that aberrant osteoclastogenesis and osteogenesis may be involved in the occurrence of ankylosed bone mass in TMJA. In this study, we characterized the osteogenesis of bone marrow stem cells and the osteoclastogenesis of myelomonocyte in clinical specimens of TMJA and normal controls. Results showed that, compared with control bone marrow stem cells, TMJA bone marrow stem cells had lower proliferative and osteogenic capacities. The number of osteoclasts in the ankylosed bone mass group dramatically decreased, and myelomonocyte osteoclastogenic potential was impaired. The RANKL/OPG ratio of the ankylosed bone mass group was lower than that of the control group. Thus, our study suggests that osteoclast deficiency may be an important factor affecting bone mass ankylosis.

语种: 英语
所属项目编号: 81170936 ; 7152155
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000361819400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60364
Appears in Collections:北京大学口腔医学院_综合治疗科_期刊论文

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作者单位: 1.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Dept Gen Dent, Beijing 100081, Peoples R China
3.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
4.Peking Univ Sch & Hosp Stomatol, Ctr TMD & Orofacial Pain, Beijing 100081, Peoples R China

Recommended Citation:
He, L. H.,Xiao, E.,Duan, D. H.,et al. Osteoclast Deficiency Contributes to Temporomandibular Joint Ankylosed Bone Mass Formation[J]. JOURNAL OF DENTAL RESEARCH,2015,94(10):1392-1400.
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