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Optimization and characterization of chemically modified polymer microspheres and their effect on cell behavior
Li, Yijiang1; Li, Chao1; Mujeeb, Ayeesha1; Jin, Zhaoxia2; Ge, Zigang1,3,4
关键词Porous materials Polymers Modification Cell culture
刊名MATERIALS LETTERS
2015-09-01
DOI10.1016/j.matlet.2015.04.064
154页:68-72
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Materials Science ; Physics
关键词[WOS]CROSS-LINKING ; MICROCARRIERS
英文摘要

Porous microspheres composed of poly (L-lactic-co-glycolic acid) (PLGA), poly (L-lactic acid) (PLA), and poly (L-lactide-co-caprolactone) (PLCL) were fabricated. Based on the hydrophilic properties and porous microstructures, PLGA (100 kDa Mw and 1.5% concentration) microspheres were selected and crosslinked with gelatin using two different chemical modification methods: ethanediamine/glutaraldehyde (EN/GA) and N-(3-dimethylaminopropyI)-N′-ethyl-carbodiimide/N-hydroxysuccinimide (EDC/NHS). The effect of chemical modification on the surface topography, porosity, wettability, and biocompatibility was evaluated. Porous microspheres modified with gelatin through ethanediamine/glutaraldehyde cross-linking improved the hydrophilic properties of PLGA and generated an open pore microstructure. A significant increase in the cell metabolic activity was recorded after 5 days in culture, suggesting that ethanediamine/glutaraldehyde may be a suitable cross-linking agent for cell culture applications. o 2015 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000356734700018
项目编号2012CB619100 ; 81471800 ; 81271722
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60368
专题北京大学第二临床医学院
作者单位1.Renmin Univ China, Dept Chem, Beijing 100871, Peoples R China
2.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
4.Peking Univ, Peoples Hosp, Arthrit Clin & Res Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Yijiang,Li, Chao,Mujeeb, Ayeesha,et al. Optimization and characterization of chemically modified polymer microspheres and their effect on cell behavior[J]. MATERIALS LETTERS,2015,154:68-72.
APA Li, Yijiang,Li, Chao,Mujeeb, Ayeesha,Jin, Zhaoxia,&Ge, Zigang.(2015).Optimization and characterization of chemically modified polymer microspheres and their effect on cell behavior.MATERIALS LETTERS,154,68-72.
MLA Li, Yijiang,et al."Optimization and characterization of chemically modified polymer microspheres and their effect on cell behavior".MATERIALS LETTERS 154(2015):68-72.
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