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学科主题: 临床医学
题名:
Optimization and characterization of chemically modified polymer microspheres and their effect on cell behavior
作者: Li, Yijiang1; Li, Chao1; Mujeeb, Ayeesha1; Jin, Zhaoxia2; Ge, Zigang1,3,4
关键词: Porous materials ; Polymers ; Modification ; Cell culture
刊名: MATERIALS LETTERS
发表日期: 2015-09-01
DOI: 10.1016/j.matlet.2015.04.064
卷: 154, 页:68-72
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Materials Science ; Physics
关键词[WOS]: CROSS-LINKING ; MICROCARRIERS
英文摘要:

Porous microspheres composed of poly (L-lactic-co-glycolic acid) (PLGA), poly (L-lactic acid) (PLA), and poly (L-lactide-co-caprolactone) (PLCL) were fabricated. Based on the hydrophilic properties and porous microstructures, PLGA (100 kDa Mw and 1.5% concentration) microspheres were selected and crosslinked with gelatin using two different chemical modification methods: ethanediamine/glutaraldehyde (EN/GA) and N-(3-dimethylaminopropyI)-N′-ethyl-carbodiimide/N-hydroxysuccinimide (EDC/NHS). The effect of chemical modification on the surface topography, porosity, wettability, and biocompatibility was evaluated. Porous microspheres modified with gelatin through ethanediamine/glutaraldehyde cross-linking improved the hydrophilic properties of PLGA and generated an open pore microstructure. A significant increase in the cell metabolic activity was recorded after 5 days in culture, suggesting that ethanediamine/glutaraldehyde may be a suitable cross-linking agent for cell culture applications. o 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2012CB619100 ; 81471800 ; 81271722
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
WOS记录号: WOS:000356734700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60368
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Renmin Univ China, Dept Chem, Beijing 100871, Peoples R China
2.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
4.Peking Univ, Peoples Hosp, Arthrit Clin & Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Li, Yijiang,Li, Chao,Mujeeb, Ayeesha,et al. Optimization and characterization of chemically modified polymer microspheres and their effect on cell behavior[J]. MATERIALS LETTERS,2015,154:68-72.
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