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Cyclin Dependent Kinase 1 Inhibitors: A Review of Recent Progress
Wang, Q.1; Su, L.1; Liu, N.1; Zhang, L.1; Xu, W.1; Fang, H.1,2
关键词Cyclin dependent kinases cell cycle mitosis G2 phase tumor CDK1 inhibitors cancer therapy agents
刊名CURRENT MEDICINAL CHEMISTRY
2011-05-01
18期:13页:2025-2043
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]CHRONIC LYMPHOCYTIC-LEUKEMIA ; STRUCTURE-BASED DESIGN ; DNA-DAMAGE CHECKPOINT ; PHASE-II TRIAL ; PHARMACODYNAMIC END-POINTS ; SQUAMOUS-CELL CARCINOMA ; ADVANCED SOLID TUMORS ; BREAST-CANCER CELLS ; CDK1 INHIBITORS ; IN-VITRO
英文摘要

Cyclin dependent kinases (CDKs) are a family of proteins involved in the regulation of cell cycle progression and attractive targets in oncology. The regulation of CDKs activities is achieved by their association with cyclin partners and kinases, phosphatases and specific inhibitors. Different CDKs complexes exert their functions at different phases. CDK1 is a master modulator in the initiation and transition process through mitosis of the cell cycle. Previous studies have shown that loss of CDK1 activity or the aberrant expression of CDK1 involved in G2 phase arrest and many tumor types, thereby validating CDK1 as a therapeutic target. Therefore, a surge of interest has been devoted to searching for potent CDK1 inhibitors as effective chemotherapeutic agents. Herein we focus, in this review, mainly on the studies about the structure, functions and different structure classes of potent CDK1 inhibitors.

语种英语
WOS记录号WOS:000290611200011
项目编号2008GG10002010 ; 2009TS111 ; K20100107
资助机构Project of Science and Technology Research in Shandong Province ; Independent Innovation Foundation of Shandong University (IIFSDU) ; State Key Laboratory of Natural and Biomimetic Drugs in Peking University
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60380
专题北京大学药学院
作者单位1.Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Shandong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Q.,Su, L.,Liu, N.,et al. Cyclin Dependent Kinase 1 Inhibitors: A Review of Recent Progress[J]. CURRENT MEDICINAL CHEMISTRY,2011,18(13):2025-2043.
APA Wang, Q.,Su, L.,Liu, N.,Zhang, L.,Xu, W.,&Fang, H..(2011).Cyclin Dependent Kinase 1 Inhibitors: A Review of Recent Progress.CURRENT MEDICINAL CHEMISTRY,18(13),2025-2043.
MLA Wang, Q.,et al."Cyclin Dependent Kinase 1 Inhibitors: A Review of Recent Progress".CURRENT MEDICINAL CHEMISTRY 18.13(2011):2025-2043.
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