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Functional and Anatomical Connectivity Abnormalities in Cognitive Division of Anterior Cingulate Cortex in Schizophrenia
Yan, Hao1,2; Tian, Lin1,2; Yan, Jun1,2; Sun, Wei1,2; Liu, Qi1,2; Zhang, Yan-Bo3,4; Li, Xin-Ming3,4; Zang, Yu-Feng5,6,7; Zhang, Dai1,2,8
刊名PLOS ONE
2012-09-25
DOI10.1371/journal.pone.0045659
7期:9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者International Science &amp ; Technology Cooperation Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; International Science &amp ; Technology Cooperation Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]EARLY-ONSET SCHIZOPHRENIA ; DIFFUSION-TENSOR MRI ; IN-VIVO MORPHOMETRY ; RESTING-STATE FMRI ; HUMAN BRAIN ; 1ST-EPISODE SCHIZOPHRENIA ; 1ST-DEGREE RELATIVES ; CEREBRAL ASYMMETRY ; BASAL GANGLIA ; DEFAULT MODE
英文摘要

Introduction: Current pathophysiological theories of schizophrenia highlight the role of altered brain functional and anatomical connectivity. The cognitive division of anterior cingulate cortex (ACC-cd) is a commonly reported abnormal brain region in schizophrenia for its importance in cognitive control process. The aim of this study was to investigate the functional and anatomical connectivity of ACC-cd and its cognitive and clinical manifestation significance in schizophrenia by using the resting-state functional magnetic resonance imaging (fMRI) and the diffusion tensor imaging (DTI).

Methods: Thirty-three medicated schizophrenics and 30 well-matched health controls were recruited. Region-of-interest (ROI)-based resting-state functional connectivity analysis and Tract-Based Spatial Statistics (TBSS) were performed on 30 patients and 30 controls, and 24 patients and 29 controls, respectively. The Pearson correlation was performed between the imaging measures and the Stroop performance and scores of the Positive and Negative Syndrome Scale (PANSS), respectively.

Results: Patients with schizophrenia showed significantly abnormal in the functional connectivity and its hemispheric asymmetry of the ACC-cd with multiple brain areas, e. g., decreased positive connectivity with the bilateral putamen and caudate, increased negative connectivity with the left posterior cingulated cortex (PCC), increased asymmetry of connectivity strength with the contralateral inferior frontal gyrus (IFG). The FA of the right anterior cingulum was significantly decreased in patients group (p = 0.014). The abnormal functional and structural connectivity of ACC-cd were correlated with Stroop performance and the severity of the symptoms in patients.

Conclusions: Our results suggested that the abnormal connectivity of the ACC-cd might play a role in the cognitive impairment and clinical symptoms in schizophrenia.

语种英语
所属项目编号2010DFB30820 ; 2011CB707805 ; 81000580 ; 81071088 ; 20100001120120
资助者International Science &amp ; Technology Cooperation Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; International Science &amp ; Technology Cooperation Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000309556100065
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60382
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Manitoba, Dept Psychiat, Winnipeg, MB R3T 2N2, Canada
4.Univ Saskatchewan, Dept Psychiat, Saskatoon, SK S7N 0W0, Canada
5.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China
6.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou, Zhejiang, Peoples R China
7.Beijing Normal Univ, Natl Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
8.Tsinghua Univ, Peking Tsinghua Ctr Life Sci, Beijing 100084, Peoples R China
推荐引用方式
GB/T 7714
Yan, Hao,Tian, Lin,Yan, Jun,et al. Functional and Anatomical Connectivity Abnormalities in Cognitive Division of Anterior Cingulate Cortex in Schizophrenia[J]. PLOS ONE,2012,7(9).
APA Yan, Hao.,Tian, Lin.,Yan, Jun.,Sun, Wei.,Liu, Qi.,...&Zhang, Dai.(2012).Functional and Anatomical Connectivity Abnormalities in Cognitive Division of Anterior Cingulate Cortex in Schizophrenia.PLOS ONE,7(9).
MLA Yan, Hao,et al."Functional and Anatomical Connectivity Abnormalities in Cognitive Division of Anterior Cingulate Cortex in Schizophrenia".PLOS ONE 7.9(2012).
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