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学科主题: 临床医学
题名:
Metabolic syndrome and androgen deprivation therapy in metabolic complications of prostate cancer patients
作者: Yuan Jia-qi; Xu Tao; Zhang Xiao-wei; Yu Lu-ping; Li Qing; Liu Shi-jun; Huang Xiao-bo; Wang Xiao-feng
关键词: prostate cancer ; hormone therapy ; orchiectomy ; metabolic syndrome ; individualized medicine
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-10-20
DOI: 10.3760/cma.j.issn.0366-6999.2012.20.023
卷: 125, 期:20, 页:3725-3729
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: BODY-COMPOSITION ; CARDIOVASCULAR-DISEASE ; RECEPTOR ANTAGONISTS ; RISK-FACTORS ; POPULATION ; ORCHIECTOMY ; JAPANESE ; CHINESE ; MALES ; MEN
英文摘要:

Background Incidence of prostate cancer in Chinese males grows significantly in the past decades. Androgen deprivation therapy has been generally employed in the treatment of locally advanced and metastatic prostate cancer for many years, yet only little data was known about the metabolic syndrome in patients receiving hormonal therapy. This study described the prevalence and the changing trends of hormone-related metabolic complications, and analyzed their correlation with different therapies.

Methods In 125 patients treated with castration or maximal androgen blockage for at least 12 months, metabolic indicators were analyzed.

Results Totally, 13.5% patients in castration group and 30.1% patients in maximal androgen blockage group were diagnosed metabolic syndrome 12 months after the beginning of treatments (chi(2)=4.739, P=0.029). In castration group, increased triglyceride and decreased high-density lipoprotein-cholesterol were significant at the month 12, increased fasting plasma glucose and blood pressure were significant at the month 4. In maximal androgen blockage group, increased triglyceride and decreased high-density lipoprotein-cholesterol were significant at the month 4, increased fasting plasma glucose and blood pressure were significant at the month 8. Total testosterone and free testosterone in maximal androgen blockage group were significantly lower than castration group at all visits, which were proved to show positive or negative correlations with metabolic indications. Severity of metabolic complications in maximal androgen blockage group was generally more serious than people received castration, with significantly statistical difference or not. Trends of high-density lipoprotein-cholesterol and fasting plasma glucose were significant different between two kinds of therapy (P=0.005, P=0.019, respectively).

Conclusions Prostate cancer patients receiving androgen deprivation therapy were at high risk of suffering metabolic syndrome. Severity of metabolic complications under different hormonal therapies were not completely consistent, suggested that androgen deprivation therapy may be individualized. Chin Med J 2012;125(20):3725-3729

语种: 英语
所属项目编号: Z101107050210025
项目资助者: Beijing Pharmaceutical and Technological Project Cultivation Research Foundation
WOS记录号: WOS:000311265100024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60384
Appears in Collections:北京大学第二临床医学院_泌尿外科_期刊论文

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作者单位: Peking Univ, Dept Urol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Yuan Jia-qi,Xu Tao,Zhang Xiao-wei,et al. Metabolic syndrome and androgen deprivation therapy in metabolic complications of prostate cancer patients[J]. CHINESE MEDICAL JOURNAL,2012,125(20):3725-3729.
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