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学科主题: 药学
题名:
8-hydroxyguanine, a product from damaged DNA can be used in the DNA salvage pathways
作者: Zeng, HH; Choi, JY; Chung, MH
关键词: 8-hydroxyguanine ; metabolic reaction ; DNA salvage pathway
刊名: CHINESE CHEMICAL LETTERS
发表日期: 2003-05-01
卷: 14, 期:5, 页:529-532
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: GENE
英文摘要:

The metabolic mechanism of 8-hydroxyguanine (8-OHGua) is so far unknown, however it is known to function in the mutagenic events in biological systems. In the present study, the metabolic processes is investigated by the reaction of 8-OHGua with PRPP catalyzed by HGPRT and Mg(II). The evidence shows that the interaction between 8-OHGua and the enzyme is indeed taken place and 8-OHGMP is formed.

语种: 英语
WOS记录号: WOS:000183628800030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60392
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Seoul Natl Univ, Coll Med, Dept Pharmacol, Chongno Gu, Seoul 110744, South Korea
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Zeng, HH,Choi, JY,Chung, MH. 8-hydroxyguanine, a product from damaged DNA can be used in the DNA salvage pathways[J]. CHINESE CHEMICAL LETTERS,2003,14(5):529-532.
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