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学科主题: 基础医学
题名:
Structure elucidation and immunological function analysis of a novel beta-glucan from the fruit bodies of Polyporus umbellatus (Pers.) Fries
作者: Dai, Hui2; Han, Xiao-Qiang3; Gong, Fang-Yuan1,4; Dong, Hongliang1,4; Tu, Peng-Fei3; Gao, Xiao-Ming1,4
关键词: beta-glucan ; immunostimulation ; lymphocyte ; macrophage ; structure
刊名: GLYCOBIOLOGY
发表日期: 2012-12-01
DOI: 10.1093/glycob/cws099
卷: 22, 期:12, 页:1673-1683
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; SERUM ANTIBODIES ; ALDITOL ACETATES ; ELEVATED LEVELS ; DECTIN-1 ; INDUCTION ; RECEPTOR ; CELLS ; POLYSACCHARIDES ; ZYMOSAN
英文摘要:

beta-Glucans derived from various sources such as yeast cell walls and medicinal mushrooms are considered as valuable biological response modifiers for their ability to enhance the activity of immune cells, aid in wound healing and help prevent infections. We herein characterize the structure of a novel water-soluble polysaccharide (Zhuling polysaccharide, ZPS) from the fruit bodies of medicinal mushroom Polyporus umbellatus and investigate its immunobiological function. ZPS has a molecular mass of 2.27 x 10(3) kDa and contains > 90% d-glucose as its monosaccharide constituent. On the basis of partial acid hydrolysis, methylation analysis, Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy and the ideal repeating unit of ZPS is established: (1 -> 6, 1 -> 4)-linked beta-d-glucopyranosyl backbone, substituted at O-3 position of (1 -> 6)-linked beta-d-glucopyranosyl by (1 -> 3)-linked beta-d-glucopyranosyl branches. ZPS consists of approximately 2930 repeating units, each contains a side chain of no more than three residues in length. Functionally, ZPS is a potent activator of B cells, macrophages and dendritic cells. Depletion of ZPS branches causes a substantial reduction in its ability not only to activate B cells in vitro but also to elicit specific IgM production in vivo. Virtually all healthy human subjects possess high-titer circulating antibodies against ZPS backbone, suggesting that ZPS epitope is shared by environmental antigens capable of eliciting adaptive humoral responses in the population.

语种: 英语
所属项目编号: IRT1075 ; 30890142/31070781/81102253 ; 2010CB529102 ; 20100001120042
项目资助者: PCSIRT ; National Foundation of Natural Science of China ; National Key Basic Research Programs ; Research Fund for the Doctoral Program of Higher Education ; Priority Academic Program Development of Jiangsu Province Higher Education Institutions
WOS记录号: WOS:000310630900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60393
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Soochow Univ, Inst Biol & Med Sci, Suzhou 215123, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Sch Basic Med Sci, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
4.Key Lab Infect & Immun Jiangsu Prov, Suzhou, Peoples R China

Recommended Citation:
Dai, Hui,Han, Xiao-Qiang,Gong, Fang-Yuan,et al. Structure elucidation and immunological function analysis of a novel beta-glucan from the fruit bodies of Polyporus umbellatus (Pers.) Fries[J]. GLYCOBIOLOGY,2012,22(12):1673-1683.
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