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学科主题: 临床医学
题名:
Cardioprotection by ischemic postconditioning is lost in isolated perfused heart from diabetic rats: Involvement of transient receptor potential vanilloid 1, calcitonin gene-related peptide and substance P
作者: Ren, Jing-Yi; Song, Jun-Xian; Lu, Ming-Yu; Chen, Hong
关键词: Ischemia/reperfusion ; Ischemic postconditioning ; Diabetes ; Transient receptor potential vanilloid 1 ; Calcitonin gene-related peptide ; Substance P
刊名: REGULATORY PEPTIDES
发表日期: 2011-08-08
DOI: 10.1016/j.regpep.2011.04.004
卷: 169, 期:1-3, 页:49-57
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Physiology
研究领域[WOS]: Endocrinology & Metabolism ; Physiology
关键词[WOS]: REPERFUSION INJURY ; ACTIVATION ; CHANNELS ; TRPV1 ; ADRENOMEDULLIN ; EXPRESSION ; PROTECTS ; REFLEX ; NERVES ; MICE
英文摘要:

We previously found that the expression of transient receptor potential vanilloid 1 (TRPV1) and contents of calcitonin gene-related peptide (CGRP) and substance P (SP), two main neuropeptides released from TRPV1, were decreased in diabetic hearts. This study aimed to test whether decreased TRPV1. CGRP and SP levels were responsible for the loss of cardioprotection by ischemic postconditioning (IPostC) in isolated perfused heart from streptozotocin-induced diabetic rats. IPostC effectively protected non-diabetic hearts against ischemia/reperfusion injury by improving cardiac function and lowering creatine kinase (CK) and cardiac troponin I (cTnI) release, which could be abolished by inhibiting TRPV1, CGRP receptor or SP receptor. However, IPostC had no effect on cardiac function and the release of CK and cTnI in diabetic hearts regardless of whether TRPV1, CGRP receptor or SP receptor were inhibited. CGRP or SP-induced postconditioning significantly prevented both non-diabetic and diabetic hearts from ischemia/reperfusion injury by improving cardiac function and lowering CK and cTnI release. Additionally. IPostC markedly increased CGRP and SP release in non-diabetic hearts, which could be reversed with TRPV1 inhibition, but not CGRP receptor or SP receptor inhibition. However, IPostC failed to affect CGRP and SP release in diabetic hearts in the presence or absence of TRPV1, CGRP receptor or SP receptor inhibition. These results indicate that the loss of cardioprotection by IPostC during diabetes is partly associated with a failure to increase CGRP and SP release, likely due to decreased TRPV1 expression and CGRP and SP contents in diabetic hearts. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 7102157
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000292368900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60394
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Ren, Jing-Yi,Song, Jun-Xian,Lu, Ming-Yu,et al. Cardioprotection by ischemic postconditioning is lost in isolated perfused heart from diabetic rats: Involvement of transient receptor potential vanilloid 1, calcitonin gene-related peptide and substance P[J]. REGULATORY PEPTIDES,2011,169(1-3):49-57.
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