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学科主题: 临床医学
题名:
Interleukin-32, not reduced by salmeterol/fluticasone propionate in smokers with chronic obstructive pulmonary disease
作者: Du Yipeng; Wang Wei; Yang Wei; He Bei
关键词: interleukins ; pulmonary disease ; chronic obstructive ; anti-inflammatory agents, interleukin 32 protein ; human
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-05-05
DOI: 10.3760/cma.j.issn.0366-6999.20132625
卷: 127, 期:9, 页:1613-1618
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: AIRWAY INFLAMMATION ; KAPPA-B ; COPD ; CYTOKINE ; IL-32 ; SPUTUM ; ASSOCIATION ; EMPHYSEMA ; ASTHMA
英文摘要:

Background The interleukin (IL)-32/tumor necrosis factor (TNF) alpha pathway is supposed to play a key role in the amplification of the immune response in chronic obstructive pulmonary disease (COPD) inflammation. Inhaled corticosteroids (ICS) in combination with long-acting beta 2-agonists (LABA) have shown airway anti-inflammatory effects in recent studies, but the mechanism is still uncertain.

Methods Patients were treated in a randomized, open-labeled, parallel group clinical trial with either a combination of salmeterol xinafoate/fluticasone propionate (SF; Seretide, GlaxoSmithKline) Diskus (50/500 mu g twice daily) or ipratropium bromide/salbutamol (IS; Combivent, Boehringer Ingelheim) MDI (42 mu g/240 mu g quartic daily) for 12 weeks. At the start and the end of treatment, induced sputum was collected and the concentration of IL-32 and TNF-alpha, the number of neutrophils and eosinophils were measured.

Results Following 12 weeks of treatment, a statistically significant fall from baseline in the concentration of TNF-alpha in sputum (P=0.004) was seen after treatment with SF but not with IS. However, neither treatment had significant effects on the concentration of IL-32 in sputum. There was a decrease from baseline in the number of sputum neutrophils with SF that approached statistical significance (P=0.028) but not with IS, while the number of sputum eosinophils did not change significantly from baseline in either treatment group. There was a statistically significant decline from baseline in the quality of life as assessed by the St George′s respiratory questionnaire in both the SF (P=0.004) and IS (P=0.030) treatment groups, but no evidence of improvement in lung function was observed in either group.

Conclusion The sputum TNF-alpha and neutrophils, but not IL-32 and macrophages, could be reduced by ICS/LABA treatment, suggesting that IL-32 could be involved in the corticosteroid resistance of COPD inflammation.

语种: 英语
所属项目编号: 30770939
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000335936800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60395
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Resp Med, Beijing 100191, Peoples R China

Recommended Citation:
Du Yipeng,Wang Wei,Yang Wei,et al. Interleukin-32, not reduced by salmeterol/fluticasone propionate in smokers with chronic obstructive pulmonary disease[J]. CHINESE MEDICAL JOURNAL,2014,127(9):1613-1618.
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