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Clinical and laboratory profiles of rhupus syndrome in a Chinese population: a single-centre study of 51 patients
Liu, T.1; Li, G.1; Mu, R.1; Ye, H.1; Li, W.2; Li, Z.1
关键词Systemic lupus erythematosus rheumatoid arthritis overlap rhupus
刊名LUPUS
2014-08-01
DOI10.1177/0961203314526439
23期:9页:958-963
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; COEXISTENT RHEUMATOID-ARTHRITIS ; REVISED CRITERIA ; ARTHROPATHY ; DISEASE ; SLE ; CLASSIFICATION ; CONCURRENCE
英文摘要

Objective: The objective of this paper is to clarify the demographic, clinical and serologic characteristics of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) overlap syndrome, known as ′rhupus syndrome′. Methods: Between 1995 and 2012, 51 patients were classified as having rhupus among 3733 consecutive SLE patients. Rhupus was defined as a condition involving an overlap of RA and SLE features meeting the respective criteria of the American College of Rheumatology. The clinical and laboratory parameters of patients with rhupus syndrome were compared with those of 230 RA patients and 120 unselected SLE patients. Results: The age at the onset of rhupus was significantly younger than that of RA (p < 0.05), but similar to that of SLE. The initial manifestation was arthritis in 84.3% (43/51) of rhupus patients. Symptoms of SLE manifested after an average of 9.2 years. SLE was the initial diagnosis in 7.8% (four of 51) of patients, whereas both diseases developed simultaneously in 7.8% of the patients. SLE-associated manifestations were mild in rhupus syndrome, particularly neurologic disorders. Haematopoietic involvement was the most prominent systemic manifestation in rhupus patients. Conclusion: Rhupus syndrome constitutes a subgroup of patients with distinct demographic, clinical and immunological characteristics. RA typically presents first, and less-severe SLE-associated damage is apparent.

语种英语
WOS记录号WOS:000339104400016
项目编号2012CB517702
资助机构National High Technology Research and Development Program of China (973 Program)
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60398
专题北京大学第二临床医学院
北京大学第一临床医学院_肾脏内科
北京大学第二临床医学院_风湿免疫科
作者单位1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Xinjiang Prod & Construct Corps, Div Hosp 13, Hami City, Peoples R China
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GB/T 7714
Liu, T.,Li, G.,Mu, R.,et al. Clinical and laboratory profiles of rhupus syndrome in a Chinese population: a single-centre study of 51 patients[J]. LUPUS,2014,23(9):958-963.
APA Liu, T.,Li, G.,Mu, R.,Ye, H.,Li, W.,&Li, Z..(2014).Clinical and laboratory profiles of rhupus syndrome in a Chinese population: a single-centre study of 51 patients.LUPUS,23(9),958-963.
MLA Liu, T.,et al."Clinical and laboratory profiles of rhupus syndrome in a Chinese population: a single-centre study of 51 patients".LUPUS 23.9(2014):958-963.
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