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学科主题: 临床医学
题名:
Clinical and laboratory profiles of rhupus syndrome in a Chinese population: a single-centre study of 51 patients
作者: Liu, T.1; Li, G.1; Mu, R.1; Ye, H.1; Li, W.2; Li, Z.1
关键词: Systemic lupus erythematosus ; rheumatoid arthritis ; overlap ; rhupus
刊名: LUPUS
发表日期: 2014-08-01
DOI: 10.1177/0961203314526439
卷: 23, 期:9, 页:958-963
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; COEXISTENT RHEUMATOID-ARTHRITIS ; REVISED CRITERIA ; ARTHROPATHY ; DISEASE ; SLE ; CLASSIFICATION ; CONCURRENCE
英文摘要:

Objective: The objective of this paper is to clarify the demographic, clinical and serologic characteristics of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) overlap syndrome, known as ′rhupus syndrome′. Methods: Between 1995 and 2012, 51 patients were classified as having rhupus among 3733 consecutive SLE patients. Rhupus was defined as a condition involving an overlap of RA and SLE features meeting the respective criteria of the American College of Rheumatology. The clinical and laboratory parameters of patients with rhupus syndrome were compared with those of 230 RA patients and 120 unselected SLE patients. Results: The age at the onset of rhupus was significantly younger than that of RA (p < 0.05), but similar to that of SLE. The initial manifestation was arthritis in 84.3% (43/51) of rhupus patients. Symptoms of SLE manifested after an average of 9.2 years. SLE was the initial diagnosis in 7.8% (four of 51) of patients, whereas both diseases developed simultaneously in 7.8% of the patients. SLE-associated manifestations were mild in rhupus syndrome, particularly neurologic disorders. Haematopoietic involvement was the most prominent systemic manifestation in rhupus patients. Conclusion: Rhupus syndrome constitutes a subgroup of patients with distinct demographic, clinical and immunological characteristics. RA typically presents first, and less-severe SLE-associated damage is apparent.

语种: 英语
所属项目编号: 2012CB517702
项目资助者: National High Technology Research and Development Program of China (973 Program)
WOS记录号: WOS:000339104400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60398
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Xinjiang Prod & Construct Corps, Div Hosp 13, Hami City, Peoples R China

Recommended Citation:
Liu, T.,Li, G.,Mu, R.,et al. Clinical and laboratory profiles of rhupus syndrome in a Chinese population: a single-centre study of 51 patients[J]. LUPUS,2014,23(9):958-963.
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