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学科主题: 临床医学
题名:
Enhanced plasma levels of LIGHT in patients with acute atherothrombotic stroke
作者: Liu, G. -Z.1; Fang, L. -B.2; Hjelmstrom, P.3; Gao, X. -G.1
关键词: atherogenesis ; ischemic atherosclerotic stroke ; LIGHT ; peripheral blood
刊名: ACTA NEUROLOGICA SCANDINAVICA
发表日期: 2008-10-01
DOI: 10.1111/j.1600-0404.2008.01013.x
卷: 118, 期:4, 页:256-259
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: SOLUBLE CD40 LIGAND ; GLYCOPROTEIN IIB/IIIA ; ENDOTHELIAL-CELLS ; UNSTABLE ANGINA ; ATHEROSCLEROSIS ; RELEASE ; PATHOGENESIS ; INFLAMMATION ; PLATELETS ; CYTOKINES
英文摘要:

Objectives - As a member of the tumor necrosis factor superfamily (TNFSF), LIGHT (TNFSF14) was recently found to be associated with platelets and released upon activation. Increased plasma levels of LIGHT have been reported in patients with myocardial infarction and unstable angina. The aim of the study was to analyze plasma levels of LIGHT in acute ischemic atherosclerotic stroke. Materials and methods - The soluble LIGHT protein was analyzed by an enzyme-linked immunosorbent assay in peripheral blood of patients with acute ischemic atherosclerotic stroke (n = 20), asymptomatic carotid stenosis (n = 19) and normal controls (n = 23). Results - During the initial 24 h after onset, the stroke patients had an increased plasma LIGHT levels as compared with normal controls. Moreover, the plasma LIGHT levels of the stroke patients were correlated with blood platelet count (r = 0.6341, P = 0.0027). Conclusion - The elevated LIGHT levels may reflect a persistent chronic inflammatory response that may have been induced during early stages of the disease. We speculate that this derangement of LIGHT may be important for atherogenetic process of ischemic stroke.

语种: 英语
所属项目编号: 11220 ; NSF 30470843
项目资助者: Swedish Research Council ; Swedish Association of Neurologically Disabled, the National Natural Science fund
WOS记录号: WOS:000258970000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60403
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
2.Capital Med Univ, Beijing Fuxing Hosp, Dept Neurol, Beijing, Peoples R China
3.Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

Recommended Citation:
Liu, G. -Z.,Fang, L. -B.,Hjelmstrom, P.,et al. Enhanced plasma levels of LIGHT in patients with acute atherothrombotic stroke[J]. ACTA NEUROLOGICA SCANDINAVICA,2008,118(4):256-259.
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