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学科主题临床医学
Enhanced plasma levels of LIGHT in patients with acute atherothrombotic stroke
Liu, G. -Z.1; Fang, L. -B.2; Hjelmstrom, P.3; Gao, X. -G.1
关键词atherogenesis ischemic atherosclerotic stroke LIGHT peripheral blood
刊名ACTA NEUROLOGICA SCANDINAVICA
2008-10-01
DOI10.1111/j.1600-0404.2008.01013.x
118期:4页:256-259
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]SOLUBLE CD40 LIGAND ; GLYCOPROTEIN IIB/IIIA ; ENDOTHELIAL-CELLS ; UNSTABLE ANGINA ; ATHEROSCLEROSIS ; RELEASE ; PATHOGENESIS ; INFLAMMATION ; PLATELETS ; CYTOKINES
英文摘要

Objectives - As a member of the tumor necrosis factor superfamily (TNFSF), LIGHT (TNFSF14) was recently found to be associated with platelets and released upon activation. Increased plasma levels of LIGHT have been reported in patients with myocardial infarction and unstable angina. The aim of the study was to analyze plasma levels of LIGHT in acute ischemic atherosclerotic stroke. Materials and methods - The soluble LIGHT protein was analyzed by an enzyme-linked immunosorbent assay in peripheral blood of patients with acute ischemic atherosclerotic stroke (n = 20), asymptomatic carotid stenosis (n = 19) and normal controls (n = 23). Results - During the initial 24 h after onset, the stroke patients had an increased plasma LIGHT levels as compared with normal controls. Moreover, the plasma LIGHT levels of the stroke patients were correlated with blood platelet count (r = 0.6341, P = 0.0027). Conclusion - The elevated LIGHT levels may reflect a persistent chronic inflammatory response that may have been induced during early stages of the disease. We speculate that this derangement of LIGHT may be important for atherogenetic process of ischemic stroke.

语种英语
WOS记录号WOS:000258970000008
项目编号11220 ; NSF 30470843
资助机构Swedish Research Council ; Swedish Association of Neurologically Disabled, the National Natural Science fund
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60403
专题北京大学第二临床医学院_神经内科
作者单位1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
2.Capital Med Univ, Beijing Fuxing Hosp, Dept Neurol, Beijing, Peoples R China
3.Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
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GB/T 7714
Liu, G. -Z.,Fang, L. -B.,Hjelmstrom, P.,et al. Enhanced plasma levels of LIGHT in patients with acute atherothrombotic stroke[J]. ACTA NEUROLOGICA SCANDINAVICA,2008,118(4):256-259.
APA Liu, G. -Z.,Fang, L. -B.,Hjelmstrom, P.,&Gao, X. -G..(2008).Enhanced plasma levels of LIGHT in patients with acute atherothrombotic stroke.ACTA NEUROLOGICA SCANDINAVICA,118(4),256-259.
MLA Liu, G. -Z.,et al."Enhanced plasma levels of LIGHT in patients with acute atherothrombotic stroke".ACTA NEUROLOGICA SCANDINAVICA 118.4(2008):256-259.
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