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Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis
Luo, Hongzhi1,2; Liu, Bo1,2; Hu, Jing3; Wang, Xian1,2; Zhan, Siyan3; Kong, Wei1,2
关键词Hyperhomocysteinemia Cervical artery dissection Polymorphism Meta-analysis
刊名CEREBROVASCULAR DISEASES
2014
DOI10.1159/000360753
37期:5页:313-322
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Peripheral Vascular Disease
资助者National Program on Key Basic Research Project (973 Program) ; National Natural Science Foundation of the PR China ; &prime ; 111&prime ; Project of the Chinese Ministry of Education ; National Science Fund for Distinguished Young Scholars ; Projects of International Cooperation and Exchanges NSFC ; National Program on Key Basic Research Project (973 Program) ; National Natural Science Foundation of the PR China ; &prime ; 111&prime ; Project of the Chinese Ministry of Education ; National Science Fund for Distinguished Young Scholars ; Projects of International Cooperation and Exchanges NSFC
研究领域[WOS]Neurosciences & Neurology ; Cardiovascular System & Cardiology
关键词[WOS]INTERNAL CAROTID-ARTERY ; PLASMA HOMOCYSTEINE ; ISCHEMIC-STROKE ; MTHFR C677T ; RISK-FACTOR ; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE ; HORDALAND HOMOCYSTEINE ; DISEASE ; MODEL ; ATHEROSCLEROSIS
英文摘要

Background: Cervical artery dissection (CAD) is a recognized cause of ischemic stroke. Hyperhomocysteinemia (HHcy), i.e. an elevated concentration of plasma homocysteine, is identified as an independent risk factor for stroke prevalence. However, an association between HHcy and CAD has so far remained unknown. Methods: A meta-analysis was performed to analyze the association between HHcy and CAD as well as the relevance of the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR), the key enzyme in homocysteine metabolism during CAD. We searched PubMed and Embase for studies reporting homocysteine concentrations or MTHFR genotype frequencies in CAD patients from 1990 to 2013. Outcomes were extracted from studies meeting the inclusion criteria and were subjected to a meta-analysis by the random-effect model. Heterogeneity was assessed by the I 2 test. Results: Eight case-control studies with 2,146 individuals fulfilled the required criteria and were included in the meta-analysis. HHcy was found to be significantly associated with CAD (pooled standardized mean difference: 0.96; 95% confidence interval, CI: 0.42-1.49; p < 0.01). We also found a significantly increased risk of CAD in individuals with the MTHFR C677T polymorphism by both the recessive model (TT vs. CT + CC; odds ratio, OR = 1.81; 95% CI: 1.22-2.67; p = 0.003) and the dominant model (TT + CT vs. CC; OR = 1.47; 95% CI: 1.08-1.99; p = 0.014). Conclusion: Our data suggest positive correlations between HHcy and CAD and between the C677T polymorphism of MTHFR and CAD. (C) 2014 S. Karger AG, Basel

语种英语
所属项目编号2012CB518002 ; 81070243 ; 81121061 ; B07001 ; 81225002 ; 81220108004
资助者National Program on Key Basic Research Project (973 Program) ; National Natural Science Foundation of the PR China ; &prime ; 111&prime ; Project of the Chinese Ministry of Education ; National Science Fund for Distinguished Young Scholars ; Projects of International Cooperation and Exchanges NSFC ; National Program on Key Basic Research Project (973 Program) ; National Natural Science Foundation of the PR China ; &prime ; 111&prime ; Project of the Chinese Ministry of Education ; National Science Fund for Distinguished Young Scholars ; Projects of International Cooperation and Exchanges NSFC
WOS记录号WOS:000339666900001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60406
专题基础医学院
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Peking Univ, Minist Educ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Luo, Hongzhi,Liu, Bo,Hu, Jing,et al. Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis[J]. CEREBROVASCULAR DISEASES,2014,37(5):313-322.
APA Luo, Hongzhi,Liu, Bo,Hu, Jing,Wang, Xian,Zhan, Siyan,&Kong, Wei.(2014).Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis.CEREBROVASCULAR DISEASES,37(5),313-322.
MLA Luo, Hongzhi,et al."Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis".CEREBROVASCULAR DISEASES 37.5(2014):313-322.
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