IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis
Luo, Hongzhi1,2; Liu, Bo1,2; Hu, Jing3; Wang, Xian1,2; Zhan, Siyan3; Kong, Wei1,2
关键词Hyperhomocysteinemia Cervical artery dissection Polymorphism Meta-analysis
刊名CEREBROVASCULAR DISEASES
2014
DOI10.1159/000360753
37期:5页:313-322
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Peripheral Vascular Disease
研究领域[WOS]Neurosciences & Neurology ; Cardiovascular System & Cardiology
关键词[WOS]INTERNAL CAROTID-ARTERY ; PLASMA HOMOCYSTEINE ; ISCHEMIC-STROKE ; MTHFR C677T ; RISK-FACTOR ; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE ; HORDALAND HOMOCYSTEINE ; DISEASE ; MODEL ; ATHEROSCLEROSIS
英文摘要

Background: Cervical artery dissection (CAD) is a recognized cause of ischemic stroke. Hyperhomocysteinemia (HHcy), i.e. an elevated concentration of plasma homocysteine, is identified as an independent risk factor for stroke prevalence. However, an association between HHcy and CAD has so far remained unknown. Methods: A meta-analysis was performed to analyze the association between HHcy and CAD as well as the relevance of the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR), the key enzyme in homocysteine metabolism during CAD. We searched PubMed and Embase for studies reporting homocysteine concentrations or MTHFR genotype frequencies in CAD patients from 1990 to 2013. Outcomes were extracted from studies meeting the inclusion criteria and were subjected to a meta-analysis by the random-effect model. Heterogeneity was assessed by the I 2 test. Results: Eight case-control studies with 2,146 individuals fulfilled the required criteria and were included in the meta-analysis. HHcy was found to be significantly associated with CAD (pooled standardized mean difference: 0.96; 95% confidence interval, CI: 0.42-1.49; p < 0.01). We also found a significantly increased risk of CAD in individuals with the MTHFR C677T polymorphism by both the recessive model (TT vs. CT + CC; odds ratio, OR = 1.81; 95% CI: 1.22-2.67; p = 0.003) and the dominant model (TT + CT vs. CC; OR = 1.47; 95% CI: 1.08-1.99; p = 0.014). Conclusion: Our data suggest positive correlations between HHcy and CAD and between the C677T polymorphism of MTHFR and CAD. (C) 2014 S. Karger AG, Basel

语种英语
WOS记录号WOS:000339666900001
项目编号2012CB518002 ; 81070243 ; 81121061 ; B07001 ; 81225002 ; 81220108004
资助机构National Program on Key Basic Research Project (973 Program) ; National Natural Science Foundation of the PR China ; &prime ; 111&prime ; Project of the Chinese Ministry of Education ; National Science Fund for Distinguished Young Scholars ; Projects of International Cooperation and Exchanges NSFC
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60406
专题北京大学基础医学院
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Peking Univ, Minist Educ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Luo, Hongzhi,Liu, Bo,Hu, Jing,et al. Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis[J]. CEREBROVASCULAR DISEASES,2014,37(5):313-322.
APA Luo, Hongzhi,Liu, Bo,Hu, Jing,Wang, Xian,Zhan, Siyan,&Kong, Wei.(2014).Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis.CEREBROVASCULAR DISEASES,37(5),313-322.
MLA Luo, Hongzhi,et al."Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis".CEREBROVASCULAR DISEASES 37.5(2014):313-322.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Hyperhomocysteinemia(156KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Luo, Hongzhi]的文章
[Liu, Bo]的文章
[Hu, Jing]的文章
百度学术
百度学术中相似的文章
[Luo, Hongzhi]的文章
[Liu, Bo]的文章
[Hu, Jing]的文章
必应学术
必应学术中相似的文章
[Luo, Hongzhi]的文章
[Liu, Bo]的文章
[Hu, Jing]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection_ A Meta-Analysis.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。