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Synthesis of 1,3-(Diethoxymethyl)-5-N,N-dimethylamino-6-methyluracil
Ma Xiao-Yan1; Wang Rui-Ping3; Li A-Min1; Chen Yan-Li1; Wang Xiao-Wei1; Zhang Zhi-Lia1; Liu Jun-Yi1,2
关键词1,3-(diethoxymethyl)-5-N,N-dimethylamino-6-methyluracil 1,3-(diethoxymethyl)-5-amino-6-methyluracil 5-nitro-6-methyluracil
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
2008-02-01
28期:2页:301-303
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]DERIVATIVES ; INHIBITORS
英文摘要

A new practical approach to prepare 1,3-(diethoxymethyl)-5-N,N-dimethylamino-6-methyluracil (5) has been realized from 6-methyluracil (1). Compound 5 is a key intermediate material in the synthesis of HIV-1 RT and methionine synthase inhibitors. 6-Methyluracil (1) reacted with HNO3-P2O5 giving 5-nitro-6-methyluracil (2), which alkylated at N-1,N-3 through reaction with ethoxymethyl chloride to give 3. Compound 3 was then reduced through treatment with HCOONH4-Pd/C and the derived C-5 amino group reacted with CH3I to convert into compound 5 in good yield.

语种中文
WOS记录号WOS:000254112800021
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60409
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomet Drug, Beijing 100083, Peoples R China
3.Capital Univ, Sch Chem Biol & Pharmaceut Sci, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Ma Xiao-Yan,Wang Rui-Ping,Li A-Min,et al. Synthesis of 1,3-(Diethoxymethyl)-5-N,N-dimethylamino-6-methyluracil[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2008,28(2):301-303.
APA Ma Xiao-Yan.,Wang Rui-Ping.,Li A-Min.,Chen Yan-Li.,Wang Xiao-Wei.,...&Liu Jun-Yi.(2008).Synthesis of 1,3-(Diethoxymethyl)-5-N,N-dimethylamino-6-methyluracil.CHINESE JOURNAL OF ORGANIC CHEMISTRY,28(2),301-303.
MLA Ma Xiao-Yan,et al."Synthesis of 1,3-(Diethoxymethyl)-5-N,N-dimethylamino-6-methyluracil".CHINESE JOURNAL OF ORGANIC CHEMISTRY 28.2(2008):301-303.
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