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学科主题: 基础医学
题名:
LAPTM4B-35 Is a Novel Prognostic Factor of Hepatocellular Carcinoma
作者: Yang, Hua1; Xiong, Fuxia1; Qi, Ruizhao2; Liu, Zhenwen2; Lin, Ming1; Rui, Jingan2; Su, Jing3; Zhou, Rouli1
关键词: lysosomal protein transmembrane 4 beta (LAPTM4B) ; Western blot ; immunohistochemistry (IHC) ; hepatocellular carcinoma (HCC) ; prognosis
刊名: JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2010-04-01
DOI: 10.1002/jso.21489
卷: 101, 期:5, 页:363-369
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: LIVER-DISEASE ; PHASE-II ; CANCER ; EXPRESSION ; SORAFENIB ; ERLOTINIB ; RESECTION ; THERAPY ; PROTEIN ; MARKER
英文摘要:

Background: LAPTM4B-35 is a 35-kDa tetra-transmembrane protein overexpressed in hepatocellular carcinoma (HCC) and promotes cell survival, proliferation, and tumorigenesis. However, the potential clinical implications of LAPTM4B-35 in HCC are still unclear. This study is aimed to investigate the correlations between LAPTM4B-35 expression and prognosis in patients with HCC.

Methods: Western blot and immunohistochemistry assays were used to determine the expression of LAPTM4B-35 in HCCs and their paired noncancerous liver tissues from 65 patients. The correlations of LAPTM4B-35 expression with clinicopathological parameters were assessed by Chi-square test. Patient survival was determined by Kaplan-Meier method and log-rank test. Cox regression was adopted for multivariate analysis of prognostic factors.

Results: LAPTM4B-35 overexpression occurred in 76.9% of HCC tissues, while only in 4.6% of noncancerous liver tissues. Overexpression of LAPTM4B-35 was significantly associated with TNM staging and invasive tumors. Patients with higher LAPTM4B-35 expression had significantly poorer overall survival (OS) and disease-free survival (DFS) (both P < 0.001). On multivariate analysis, elevated expression of LAPTM4B-35 was found to be an independent prognostic factor for OS and DFS (P = 0.009, 0.043, respectively).

Conclusions: LAPTM4B-35 overexpression is an independent prognostic factor for OS and DFS of HCC. J. Surg. Oncol. 2010;101:363-369. (C) 2010 Wiley-Liss, Inc.

语种: 英语
所属项目编号: H020220020310 ; 7041003
项目资助者: special fund for promotion of education, Ministry of Education ; 248 major R&amp ; D program of Beijing ; Natural Science Foundation of Beijing
WOS记录号: WOS:000276858500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60419
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.302 Hosp Peoples Liberat Army, Dept Liver & Gallbladder Surg, Beijing, Peoples R China
3.Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Hua,Xiong, Fuxia,Qi, Ruizhao,et al. LAPTM4B-35 Is a Novel Prognostic Factor of Hepatocellular Carcinoma[J]. JOURNAL OF SURGICAL ONCOLOGY,2010,101(5):363-369.
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