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Multiple Oral Candida Infections in Patients with Sjogren′s Syndrome - Prevalence and Clinical and Drug Susceptibility Profiles
Yan, Zhimin2; Young, Andrew L.3; Hua, Hong2; Xu, Yanying1
关键词SJOGREN&prime S SYNDROME ORAL CANDIDIASIS DRUG RESISTANCE
刊名JOURNAL OF RHEUMATOLOGY
2011-11-01
DOI10.3899/jrheum.100819
38期:11页:2428-2431
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ALBICANS ; CARRIAGE
英文摘要

Objective. To determine the prevalence of oral candidiasis and multiple oral Candida infections in patients with primary Sjogren′s syndrome (SS), and the clinical and drug susceptibility profile.

Methods. Thirty patients with primary SS were enrolled in our study. The diagnosis of oral candidiasis was based on the clinical manifestation, and confirmed by a concentrated rinse culture. Candida spp. assessment was accomplished using standard methods: Sabouraud dextrose agar with 50 mg/l chloramphenicol and CHROMagar were used for the rapid screening of clinical species, followed by the API 20C system for further species identification. In vitro antifungal drug susceptibility of Candida isolates was determined by the minimal inhibitory concentrations.

Results. In our study, 87% (26/30) of subjects had oral candidiasis, in which 42% (11/26) had multiple Candida spp. infection. Although C. albicans remains the predominant isolate, other rare species such as C. tropicalis, C. glabrata, C. parapsilosis, and C. krusei were present, alone or in combination. Chronic atrophic candidiasis is the most common clinical type of oral candidiasis in patients with SS. The susceptibilities of the 44 Candida isolates to 7 antifungal agents varied dramatically. The resistance to azoles was remarkable, and the phenomenon of cross-resistance between itraconazole and fluconazole was observed.

Conclusion. Patients with primary SS carry a high risk of oral candidiasis and a high frequency of multiple Candida infections. The azole resistance patterns of Candida spp. support the necessity for drug susceptibility testing as a routine procedure for patients with oral Candida infections. (First Release Aug 15 2011; J Rheumatol 2011;38:2428-31; doi:10.3899/jrheum.100819)

语种英语
WOS记录号WOS:000297564100023
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60432
专题北京大学口腔医学院
北京大学口腔医学院_口腔黏膜科
作者单位1.Natl Nat Sci Fdn China, Dept Hlth Sci, Beijing 100085, Peoples R China
2.Peking Univ, Dept Oral Med, Sch Stomatol, Beijing 100871, Peoples R China
3.Univ Pacific, Dept Pathol & Med, Arthur Dugoni Sch Dent, San Francisco, CA USA
推荐引用方式
GB/T 7714
Yan, Zhimin,Young, Andrew L.,Hua, Hong,et al. Multiple Oral Candida Infections in Patients with Sjogren′s Syndrome - Prevalence and Clinical and Drug Susceptibility Profiles[J]. JOURNAL OF RHEUMATOLOGY,2011,38(11):2428-2431.
APA Yan, Zhimin,Young, Andrew L.,Hua, Hong,&Xu, Yanying.(2011).Multiple Oral Candida Infections in Patients with Sjogren′s Syndrome - Prevalence and Clinical and Drug Susceptibility Profiles.JOURNAL OF RHEUMATOLOGY,38(11),2428-2431.
MLA Yan, Zhimin,et al."Multiple Oral Candida Infections in Patients with Sjogren′s Syndrome - Prevalence and Clinical and Drug Susceptibility Profiles".JOURNAL OF RHEUMATOLOGY 38.11(2011):2428-2431.
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