IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Differential thymosin beta 10 expression levels and actin filament organization in tumor cell lines with different metastatic potential
Liu, CR; Ma, CS; Ning, JY; You, JF; Liao, SL; Zheng, J
关键词thymosin beta 10 tumor cell metastatic potential cell motility actin skeleton
刊名CHINESE MEDICAL JOURNAL
2004-02-01
117期:2页:213-218
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]HUMAN BREAST-CANCER ; BETA-THYMOSINS ; MOTILITY ; OVEREXPRESSION ; POLYMERIZATION
英文摘要

Background To investigate the differential expression levels of thymosin beta10 ( Tbeta10) and the corresponding changes of actin filament organization in human tumor cell lines with different metastatic potential.

Methods Four groups of nine human tumor cell lines with different metastatic potential were analyzed for the amount of Tbeta10 mRNAs by Northern blot and for their peptide expression levels by immunohistochemistry. The filamentous actin ( F-actin) was observed by staining of TRITC-phalloidin to detect changes in actin organization.

Results In comparison with non-/weakly metastatic counterparts, Tbeta10 was upregulated in highly metastatic human lung cancer, malignant melanoma and breast cancer cell lines. Staining of TRITC-phalloidin revealed less actin bundles, a fuzzy network of shorter filaments and some F-actin aggregates in the highly metastatic tumor cells. Meanwhile, the actin filaments were robust and orderly arranged in the non-/weakly metastatic cancer cell lines.

Conclusion Tbeta10 levels correlate positively with the metastatic capacity in human tumors currently examined. The increasing metastatic potential of tumor cells is accompanied by a loss of F-actin, poorly arranged actin skeleton organizations and presence of F-actin aggregates. There is a consistent correlation between the elevated Tbeta10 expression and the disrupted actin skeleton.

语种英语
WOS记录号WOS:000220107900011
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60434
专题北京大学基础医学院_病理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China
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GB/T 7714
Liu, CR,Ma, CS,Ning, JY,et al. Differential thymosin beta 10 expression levels and actin filament organization in tumor cell lines with different metastatic potential[J]. CHINESE MEDICAL JOURNAL,2004,117(2):213-218.
APA Liu, CR,Ma, CS,Ning, JY,You, JF,Liao, SL,&Zheng, J.(2004).Differential thymosin beta 10 expression levels and actin filament organization in tumor cell lines with different metastatic potential.CHINESE MEDICAL JOURNAL,117(2),213-218.
MLA Liu, CR,et al."Differential thymosin beta 10 expression levels and actin filament organization in tumor cell lines with different metastatic potential".CHINESE MEDICAL JOURNAL 117.2(2004):213-218.
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