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学科主题: 药学
题名:
Progress of Computer-Aided Drug Design (CADD) of Proteasome Inhibitors
作者: Lei, Meng1; Liu, Yunde1; Zhu, Yongqiang1; Liu, Zhenming2
关键词: Proteasome inhibitor ; Computer-aided drug design ; Rational drug design
刊名: CURRENT TOPICS IN MEDICINAL CHEMISTRY
发表日期: 2011-12-01
卷: 11, 期:23, 页:2931-2944
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CARBORANE-CONTAINING COMPOUNDS ; CHYMOTRYPSIN-LIKE ACTIVITY ; MAMMALIAN 20S PROTEASOME ; 2.75 ANGSTROM RESOLUTION ; GREEN TEA CONSUMPTION ; CRYSTAL-STRUCTURE ; MULTIPLE-MYELOMA ; TYROPEPTIN-A ; (-)-EPIGALLOCATECHIN GALLATE ; PROTEIN-DEGRADATION
英文摘要:

The target proteasome has been the focus of drug discovery since the first drug bortezomib was launched in 2003. Many structurally diverse proteasome inhibitors were discovered and even some of them entered the clinical trials. Due to rapid technological progress in chemistry, bioinformatics, structural biology and computer technology, computer-aided drug design (CADD) plays a more and more important role in today′s drug discovery. Many CADD technologies were employed in designing various inhibitors of proteasome in the past years. This review gives a global description of the development of computer-aided proteasome inhibitor design by using different commercial or academic software. The binding modes of some structurally novel inhibitors with proteasome were visualized with these new technologies.

语种: 英语
WOS记录号: WOS:000299349400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60435
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Tianjin Med Univ, Tianjin 300070, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Lei, Meng,Liu, Yunde,Zhu, Yongqiang,et al. Progress of Computer-Aided Drug Design (CADD) of Proteasome Inhibitors[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2011,11(23):2931-2944.
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