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Progress of Computer-Aided Drug Design (CADD) of Proteasome Inhibitors
Lei, Meng1; Liu, Yunde1; Zhu, Yongqiang1; Liu, Zhenming2
关键词Proteasome inhibitor Computer-aided drug design Rational drug design
刊名CURRENT TOPICS IN MEDICINAL CHEMISTRY
2011-12-01
11期:23页:2931-2944
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CARBORANE-CONTAINING COMPOUNDS ; CHYMOTRYPSIN-LIKE ACTIVITY ; MAMMALIAN 20S PROTEASOME ; 2.75 ANGSTROM RESOLUTION ; GREEN TEA CONSUMPTION ; CRYSTAL-STRUCTURE ; MULTIPLE-MYELOMA ; TYROPEPTIN-A ; (-)-EPIGALLOCATECHIN GALLATE ; PROTEIN-DEGRADATION
英文摘要

The target proteasome has been the focus of drug discovery since the first drug bortezomib was launched in 2003. Many structurally diverse proteasome inhibitors were discovered and even some of them entered the clinical trials. Due to rapid technological progress in chemistry, bioinformatics, structural biology and computer technology, computer-aided drug design (CADD) plays a more and more important role in today′s drug discovery. Many CADD technologies were employed in designing various inhibitors of proteasome in the past years. This review gives a global description of the development of computer-aided proteasome inhibitor design by using different commercial or academic software. The binding modes of some structurally novel inhibitors with proteasome were visualized with these new technologies.

语种英语
WOS记录号WOS:000299349400007
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60435
专题北京大学药学院
北京大学药学院_药物化学系
作者单位1.Tianjin Med Univ, Tianjin 300070, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Lei, Meng,Liu, Yunde,Zhu, Yongqiang,et al. Progress of Computer-Aided Drug Design (CADD) of Proteasome Inhibitors[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2011,11(23):2931-2944.
APA Lei, Meng,Liu, Yunde,Zhu, Yongqiang,&Liu, Zhenming.(2011).Progress of Computer-Aided Drug Design (CADD) of Proteasome Inhibitors.CURRENT TOPICS IN MEDICINAL CHEMISTRY,11(23),2931-2944.
MLA Lei, Meng,et al."Progress of Computer-Aided Drug Design (CADD) of Proteasome Inhibitors".CURRENT TOPICS IN MEDICINAL CHEMISTRY 11.23(2011):2931-2944.
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