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学科主题: 基础医学
题名:
Hypoxia-inducible factor-1 in tumour angiogenesis
作者: Shi, Yong-Hong; Fang, Wei-Gang
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2004-04-15
卷: 10, 期:8, 页:1082-1087
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; FACTOR 1-ALPHA ; FACTOR EXPRESSION ; PHOSPHATIDYLINOSITOL 3-KINASE ; SIGNALING PATHWAY ; GENE-EXPRESSION ; FACTOR (HIF)-1-ALPHA ; SUPPRESSOR PROTEIN ; GLYCOGEN-SYNTHASE ; EPITHELIAL-CELLS
英文摘要:

Hypoxia-inducible factor-1 (HIF-1), composed of HIF-alpha and HIF-beta subunits, is a heterodimeric transcriptional activator. In response to hypoxia, stimulation of growth factors, and activation of oncogenes as well as carcinogens, HIF-1 alpha is overexpressed and/or activated and targets those genes which are required for angiogenesis, metabolic adaptation to low oxygen and promotes survival. HIF-1 is critical for both physiological and pathological processes. Several dozens of putative direct HIF-1 target genes have been identified on the basis of one or more cis-acting hypoxia-response elements that contain an HIF-1 binding site. A variety of regulators including growth factors, genetic alterations, stress activators, and some carcinogens have been documented for regulation of HIF-1 in which several signaling pathways are involved depending on the stimuli and cell types. Activation of HIF-1 in combination with activated signaling pathways and regulators is implicated in tumour progression and prognosis. This review presents a summary of the structure and function of HIF-1 alpha, and correlation among specific regulators and their signaling pathways.

语种: 英语
所属项目编号: H020920030390
项目资助者: Committee of Beijing Science and Technology
WOS记录号: WOS:000208097600002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60439
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Pathol, Inner Mongolian Med Coll, Beijing 100083, Peoples R China

Recommended Citation:
Shi, Yong-Hong,Fang, Wei-Gang. Hypoxia-inducible factor-1 in tumour angiogenesis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(8):1082-1087.
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