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学科主题基础医学
Hypoxia-inducible factor-1 in tumour angiogenesis
Shi, Yong-Hong; Fang, Wei-Gang
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2004-04-15
10期:8页:1082-1087
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者Committee of Beijing Science and Technology ; Committee of Beijing Science and Technology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; FACTOR 1-ALPHA ; FACTOR EXPRESSION ; PHOSPHATIDYLINOSITOL 3-KINASE ; SIGNALING PATHWAY ; GENE-EXPRESSION ; FACTOR (HIF)-1-ALPHA ; SUPPRESSOR PROTEIN ; GLYCOGEN-SYNTHASE ; EPITHELIAL-CELLS
英文摘要

Hypoxia-inducible factor-1 (HIF-1), composed of HIF-alpha and HIF-beta subunits, is a heterodimeric transcriptional activator. In response to hypoxia, stimulation of growth factors, and activation of oncogenes as well as carcinogens, HIF-1 alpha is overexpressed and/or activated and targets those genes which are required for angiogenesis, metabolic adaptation to low oxygen and promotes survival. HIF-1 is critical for both physiological and pathological processes. Several dozens of putative direct HIF-1 target genes have been identified on the basis of one or more cis-acting hypoxia-response elements that contain an HIF-1 binding site. A variety of regulators including growth factors, genetic alterations, stress activators, and some carcinogens have been documented for regulation of HIF-1 in which several signaling pathways are involved depending on the stimuli and cell types. Activation of HIF-1 in combination with activated signaling pathways and regulators is implicated in tumour progression and prognosis. This review presents a summary of the structure and function of HIF-1 alpha, and correlation among specific regulators and their signaling pathways.

语种英语
所属项目编号H020920030390
资助者Committee of Beijing Science and Technology ; Committee of Beijing Science and Technology
WOS记录号WOS:000208097600002
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60439
专题基础医学院_病理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Pathol, Inner Mongolian Med Coll, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Shi, Yong-Hong,Fang, Wei-Gang. Hypoxia-inducible factor-1 in tumour angiogenesis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(8):1082-1087.
APA Shi, Yong-Hong,&Fang, Wei-Gang.(2004).Hypoxia-inducible factor-1 in tumour angiogenesis.WORLD JOURNAL OF GASTROENTEROLOGY,10(8),1082-1087.
MLA Shi, Yong-Hong,et al."Hypoxia-inducible factor-1 in tumour angiogenesis".WORLD JOURNAL OF GASTROENTEROLOGY 10.8(2004):1082-1087.
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