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IR@PKUHSC  > 北京大学第二临床医学院  > 肝胆外科  > 期刊论文
学科主题: 临床医学
题名:
Simultaneous Measurements of Serum AFP; GPC-3 and HCCR for Diagnosing Hepatocellular Carcinoma
作者: Qiao, Shi-Shi1,2; Cui, Zhu-Qing-Qing1; Gong, Lei1; Han, Hui1; Chen, Peng-Cheng1; Guo, Li-Min1; Yu, Xin1; Wei, Yu-Hua1; Ha, Seon-Ah3,4; Kim, Jin Woo3,4; Jin, Zhong-Tian1; Li, Shu1; Peng, Ji-Run1; Leng, Xi-Sheng1
关键词: HCC ; Biomarkers ; AFP ; GPC-3 ; HCCR ; Diagnosis
刊名: HEPATO-GASTROENTEROLOGY
发表日期: 2011-09-01
卷: 58, 期:110, 页:1718-1724
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: GLYPICAN-3 EXPRESSION ; ALPHA-FETOPROTEIN ; P53 STABILIZATION ; ONCOGENE ; CANCER ; MARKER ; IDENTIFICATION ; PROTEIN ; GENE
英文摘要:

Background/Aims: Hepatocellular carcinoma (HCC) is a prevalent malignant tumor. Tumor markers are very useful in early diagnosis; however a single marker is rather limited. We launched a test to increase the diagnostic sensitivity through the combined detection.

Methodology: Serum concentration of three tumor-markers, Glypican-3 (GPC-3), Human-Cervical-Cancer-Oncogene (HCCR) and alpha-fetoprotein (AFP), were determined in 189 samples: 101 cases of HCC, 40 cases of cirrhosis, 18 cases of hepatitis and 30 cases of control healthy donors. Every marker was evaluated for its diagnostic value by one-way-analysis-of-variance and receiver-operating-characteristics analysis.

Results: GPC-3 was the best marker with an area under the curve (AUC) of 0.892; using 26.8ng/mL as the cut-off for HCC diagnosis, GPC-3 has a sensitivity of 51.5% and maintains a specificity of 92.8%. HCCR, with an AUC of 0.831, can reach a sensitivity of 22.8% and maintain a specificity of 90.9% if the cut-off is set as 58.8mAU/mL With an AUC of 0.827, the efficacy and sensitivity of AFP were 36.6% and 98.5% when using 199.3ng/mL as the cut-off. No significant correlation was found between these three markers. Simultaneously detecting three markers can significantly increases the sensitivity to 80.2%, much higher than AFP alone.

Conclusions: GPC-3 and HCCR are useful tumor markers complementary to AFP for clinical diagnosis of HCC.

语种: 英语
所属项目编号: RDK 2008-05
项目资助者: Peking University People&prime ; s Hospital ; First Affiliated Hospital of Zhengzhou University
WOS记录号: WOS:000297604500055
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60442
Appears in Collections:北京大学第二临床医学院_肝胆外科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100044, Peoples R China
2.Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Zhengzhou, Henan Province, Peoples R China
3.Catholic Univ Korea, Coll Med, Mol Genet Lab, Seoul, South Korea
4.Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea

Recommended Citation:
Qiao, Shi-Shi,Cui, Zhu-Qing-Qing,Gong, Lei,et al. Simultaneous Measurements of Serum AFP; GPC-3 and HCCR for Diagnosing Hepatocellular Carcinoma[J]. HEPATO-GASTROENTEROLOGY,2011,58(110):1718-1724.
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