IR@PKUHSC  > 北京大学第二临床医学院  > 肝胆外科
学科主题临床医学
Simultaneous Measurements of Serum AFP; GPC-3 and HCCR for Diagnosing Hepatocellular Carcinoma
Qiao, Shi-Shi1,2; Cui, Zhu-Qing-Qing1; Gong, Lei1; Han, Hui1; Chen, Peng-Cheng1; Guo, Li-Min1; Yu, Xin1; Wei, Yu-Hua1; Ha, Seon-Ah3,4; Kim, Jin Woo3,4; Jin, Zhong-Tian1; Li, Shu1; Peng, Ji-Run1; Leng, Xi-Sheng1
关键词HCC Biomarkers AFP GPC-3 HCCR Diagnosis
刊名HEPATO-GASTROENTEROLOGY
2011-09-01
58期:110页:1718-1724
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]GLYPICAN-3 EXPRESSION ; ALPHA-FETOPROTEIN ; P53 STABILIZATION ; ONCOGENE ; CANCER ; MARKER ; IDENTIFICATION ; PROTEIN ; GENE
英文摘要

Background/Aims: Hepatocellular carcinoma (HCC) is a prevalent malignant tumor. Tumor markers are very useful in early diagnosis; however a single marker is rather limited. We launched a test to increase the diagnostic sensitivity through the combined detection.

Methodology: Serum concentration of three tumor-markers, Glypican-3 (GPC-3), Human-Cervical-Cancer-Oncogene (HCCR) and alpha-fetoprotein (AFP), were determined in 189 samples: 101 cases of HCC, 40 cases of cirrhosis, 18 cases of hepatitis and 30 cases of control healthy donors. Every marker was evaluated for its diagnostic value by one-way-analysis-of-variance and receiver-operating-characteristics analysis.

Results: GPC-3 was the best marker with an area under the curve (AUC) of 0.892; using 26.8ng/mL as the cut-off for HCC diagnosis, GPC-3 has a sensitivity of 51.5% and maintains a specificity of 92.8%. HCCR, with an AUC of 0.831, can reach a sensitivity of 22.8% and maintain a specificity of 90.9% if the cut-off is set as 58.8mAU/mL With an AUC of 0.827, the efficacy and sensitivity of AFP were 36.6% and 98.5% when using 199.3ng/mL as the cut-off. No significant correlation was found between these three markers. Simultaneously detecting three markers can significantly increases the sensitivity to 80.2%, much higher than AFP alone.

Conclusions: GPC-3 and HCCR are useful tumor markers complementary to AFP for clinical diagnosis of HCC.

语种英语
WOS记录号WOS:000297604500055
项目编号RDK 2008-05
资助机构Peking University People&prime ; s Hospital ; First Affiliated Hospital of Zhengzhou University
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60442
专题北京大学第二临床医学院_肝胆外科
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100044, Peoples R China
2.Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Zhengzhou, Henan Province, Peoples R China
3.Catholic Univ Korea, Coll Med, Mol Genet Lab, Seoul, South Korea
4.Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea
推荐引用方式
GB/T 7714
Qiao, Shi-Shi,Cui, Zhu-Qing-Qing,Gong, Lei,et al. Simultaneous Measurements of Serum AFP; GPC-3 and HCCR for Diagnosing Hepatocellular Carcinoma[J]. HEPATO-GASTROENTEROLOGY,2011,58(110):1718-1724.
APA Qiao, Shi-Shi.,Cui, Zhu-Qing-Qing.,Gong, Lei.,Han, Hui.,Chen, Peng-Cheng.,...&Leng, Xi-Sheng.(2011).Simultaneous Measurements of Serum AFP; GPC-3 and HCCR for Diagnosing Hepatocellular Carcinoma.HEPATO-GASTROENTEROLOGY,58(110),1718-1724.
MLA Qiao, Shi-Shi,et al."Simultaneous Measurements of Serum AFP; GPC-3 and HCCR for Diagnosing Hepatocellular Carcinoma".HEPATO-GASTROENTEROLOGY 58.110(2011):1718-1724.
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